DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and chd4a

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_021323760.1	Gene:	chd4a / 558344	ZFINID:	ZDB-GENE-041111-187	Length:	1931	Species:	Danio rerio

Alignment Length:	936	Identity:	507/936 - (54%)
Similarity:	650/936 - (69%)	Gaps:	81/936 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WKTPGKASKDKRPKTNAKKQKFRDE--EYCKVCSDGGDLLCCDSCPSVYHRTCLSPPLKSIPKGD 73
            |:....||:.:.......:.:..|.  |:|:||.|||:|||||||||.||..||:|||..||.|:
Zfish   405 WEAREDASEGEEDNEAGGEAEEDDHHMEFCRVCKDGGELLCCDSCPSSYHIHCLNPPLPEIPNGE 469

  Fly    74 WICPRCI--PLPGKAEKILSWRWA-------LDRSVELRTS-------KGEKRREYFIKWHGMSY 122
            ||||||.  .:.||.:|||:|||.       :.|..:|.|.       .|...||:|:||..|||
Zfish   470 WICPRCTCPSMKGKVQKILTWRWTEPPPPTPVPRPSDLPTDAPDPTPLAGRPEREFFVKWQNMSY 534

  Fly   123 WHCEWIPEGQMLLHHASMVASFQRRSDMEEP--------SLEELDDQD-------GNLHERFYRY 172
            |||.|:.|.|:.:|...|..::||::||:||        ..||..|:.       ..:.|::||:
Zfish   535 WHCSWVTELQLEIHCQVMFRNYQRKNDMDEPPPIDFGGEGEEEKSDKRKKKDPTYARMEEKYYRF 599

  Fly   173 GIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALY--------- 228
            |||.||:::.|::|||.:......||:|||:|:|:.::||.|...:|..:.....|
Zfish   600 GIKMEWMVIHRILNHSVDKKNNCHYLIKWRDLTYDQATWELEDMDLPDYDTYKLQYWNHRELMMG 664

  Fly   229 ------KKLRSSNKGRQRDRPA--PTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQG 285
                  ||::...|.|:.|||.  |.:|...|:|.||.:|...|..|||:|:||::|||:||.||
Zfish   665 DEGKPGKKIKIKGKMRKLDRPPENPVVDPTIKFERQPDYLDTTGGTLHPYQLEGLNWLRFSWAQG 729

  Fly   286 IPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGG 350
            ..||||||||||||:||.||||||:||||.:||||:|.||||:.|||||.|:|||::|.|||||.
Zfish   730 TDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGD 794

  Fly   351 KTARAVIRKHEISFEEVTTK-----TMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDE 410
            |.:|||||::|.|||....:     :..:.:...||:|:|||||.|::|.|.||.||||.|||||
Zfish   795 KDSRAVIRENEFSFENNAIRGGKKPSKMKKEASVKFHVLLTSYELITIDTAVLGSIDWACLVVDE 859

  Fly   411 AHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSK 475
            ||||::|||||||||:.|.:.:|||||||||||||||||||||||:..:|::|:.|..||.|::|
Zfish   860 AHRLKNNQSKFFRILNNYPLQHKLLLTGTPLQNNLEELFHLLNFLTPERFSNLEGFLEEFADIAK 924

  Fly   476 EEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGR 540
            |:|:|:||::|.|||||||||||.|.||.|:|.|||||||.||||:||.|||:||:|||.:|||.
Zfish   925 EDQIKKLHDMLGPHMLRRLKADVFKHMPSKTELIVRVELSPMQKKYYKFILTRNFEALNTRGGGN 989

  Fly   541 VCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRV 605
            ..||||::|||:||||||||||:||.||...|:|:||...|||:||||.||.|||::||...|||
Zfish   990 QVSLLNVVMDLKKCCNHPYLFPAAAMEAAKMPNGMYEGGGLTKSSGKLLLLQKMLRKLKEGGHRV 1054

  Fly   606 LLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGIN 670
            |:||||||||::||.|||.|||:|:||||.|.|.:||:||||||.|.:..|||||||||||||||
Zfish  1055 LIFSQMTKMLDLLEDFLENEGYKYERIDGGITGGMRQEAIDRFNAPGAPQFVFLLSTRAGGLGIN 1119

  Fly   671 LATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVV 735
            |||||||:|:|||||||||:||||||||:||.||||||||||..||||||.||||.|||||||||
Zfish  1120 LATADTVVIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTKASVEERITQVAKKKMMLTHLVV 1184

  Fly   736 RPGMGGMTTNFSKDELEDILRFGTEDLFKD-GKSE---------AIHYDDKAVADLLDRTNRGIE 790
            |||:|..|.:.||.||:|||:||||:|||| |:.|         .|||||||:..||||.....:
Zfish  1185 RPGLGSKTGSMSKQELDDILKFGTEELFKDEGEGENKEGQEDSSVIHYDDKAIDRLLDRNQDATD 1249

  Fly   791 EKESWA-NEYLSSFKVASYATKEDHEEHDDYNND----AENTDPFYWENLMGKSQPKLPKKQKKQ 850
            :.|..: ||||||||||.|..|::.|..::...:    .|:.||.|||.|:           :..
Zfish  1250 DTELQSMNEYLSSFKVAQYVVKDEEEAEEEVQREIIKQEESVDPDYWEKLL-----------RHH 1303

  Fly   851 SQQSQVDVESIMGKGKRIRKEIDYSN 876
            .:|.|.|:...:||||||||:::|::
Zfish  1304 YEQQQEDLARNLGKGKRIRKQVNYND 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	29/41 (71%)
		CHROMO	85..147	CDD:237991	28/75 (37%)
		CHROMO	181..233	CDD:214605	18/66 (27%)
		SNF2_N	270..561	CDD:278600	194/295 (66%)
		DEXDc	288..440	CDD:238005	100/156 (64%)
		Helicase_C	585..700	CDD:278689	87/114 (76%)
chd4a	XP_021323760.1	CHDNT	153..206	CDD:311840
		OxoGdeHyase_C	196..>280	CDD:330401
		PHD1_CHD_II	356..398	CDD:277006
		PHD2_CHD_II	433..475	CDD:277007	29/41 (71%)
		CHROMO	<522..559	CDD:237991	17/36 (47%)
		Chromo	607..659	CDD:306815	16/51 (31%)
		SNF2_N	709..>1250	CDD:331286	362/540 (67%)
		DUF1087	1280..1334	CDD:310812	19/61 (31%)
		DUF1086	1368..1502	CDD:310809
		Neuromodulin_N	<1547..>1713	CDD:331332
		CHDCT2	1747..1917	CDD:311841
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920