DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and chd5

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_009304380.1	Gene:	chd5 / 553422	ZFINID:	ZDB-GENE-120314-2	Length:	2024	Species:	Danio rerio

Alignment Length:	989	Identity:	521/989 - (52%)
Similarity:	655/989 - (66%)	Gaps:	131/989 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPD--------WKTP--------GKASKDKRPKTNAKKQKFRDE-EYCKVCSDGGDLLCCDSCPS 55
            ||:        |..|        .:|..|:..:.....::..|. |:|:||.|||:|||||:|||
Zfish   379 DPELEKAPEGKWSCPHCEKEGIQWEAKDDEEEEDEVAGEEEDDHMEFCRVCKDGGELLCCDTCPS 443

  Fly    56 VYHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWA---LDRSVELRTS---------- 105
            .||..||:|||..||.|:|:||||:  ||.||.:|||.|.|.   |...|.|...
Zfish   444 SYHIHCLNPPLPEIPNGEWLCPRCMCPPLKGKVQKILHWSWGDPPLPPEVPLGPDGEKVDNLAKT 508

  Fly   106 --KGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEP-------SLEEL--- 158
              ||...|:.|:||.|:|||||.|:.|.|:.|:|..|..::||::||:||       ..|||
Zfish   509 PLKGRPERQLFVKWAGLSYWHCSWVSELQLELYHTVMYRNYQRKNDMDEPPPYDYGSGEEELNNE 573

  Fly   159 -----DDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSI 218
                 |.|...:.|||||||||||||::.|::|||.:.:|...||:|||:|.|:..|||.:...:
Zfish   574 KRRSKDPQYAAMEERFYRYGIKPEWLIIHRILNHSFDKDGDVQYLIKWRDLPYDQCSWEADDFDV 638

  Fly   219 P-----------------GLNQAIALYKK-LRSSNKGRQRDRP--APTIDLNKKYEDQPVFLKEA 263
            |                 |.|....|::| .|...:.::|:.|  .|.:|...|:|.||.::.:.
Zfish   639 PDYDSLKQAYWDHRNQVLGENHQPLLFRKGKRPKEEMKRREPPPDTPVVDPTIKFEQQPWYIDDT 703

  Fly   264 GLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTL 328
            |..|||:|:||::|||:||.||..||||||||||||:||:||||||:||||.:||||:|.||||:
Zfish   704 GGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPFLVSAPLSTI 768

  Fly   329 TNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMR-----ENQTQYKFNVMLTSY 388
            .|||||.|:|||:.|.|||.|.|.:||:||::|.:||:...|:.|     :..|..||:|:||||
Zfish   769 INWEREFEMWAPDFYVVTYTGDKESRAIIRENEFTFEDSAVKSGRKVFRMKKDTPIKFHVLLTSY 833

  Fly   389 EFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLN 453
            |.|::|.|.||.|.||.|||||||||::|||||||||:.|:|.||||||||||||||||||||||
Zfish   834 ELITIDQAILGSITWACLVVDEAHRLKNNQSKFFRILNGYKIYYKLLLTGTPLQNNLEELFHLLN 898

  Fly   454 FLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQ 518
            ||:..:||:|:.|..||.|:|||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.||
Zfish   899 FLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQ 963

  Fly   519 KKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTK 583
            ||:||.|||:||:|||.||||...|||||||||:||||||||||.||.||.:.|:|.|:.:.|.|
Zfish   964 KKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGNLLVK 1028

  Fly   584 ASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRF 648
            :||||.||.|||.:||...||||:||||||||::||.|||.|||:|:||||.|.|.|||:|||||
Zfish  1029 SSGKLTLLQKMLIKLKDGGHRVLIFSQMTKMLDLLEDFLEFEGYKYERIDGGITGGLRQEAIDRF 1093

  Fly   649 NDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTH 713
            |.|.::.|.||||||||||||||||||||||:|||||||||:||||||||:||.||||||||||.
Zfish  1094 NAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTR 1158

  Fly   714 NSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSEA-------- 770
            .||||||.||||.||||||||||||:|..|.:.||.||:|||:||||:||||....|
Zfish  1159 ASVEERITQVAKRKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDDVEAARTMGELKV 1223

  Fly   771 ----------------------------------IHYDDKAVADLLDRTNRGIEEKE-SWANEYL 800
                                              |||||.|::.||||:....|:.| ...||||
Zfish  1224 LEMKSIVLPLCVPIAEVLNLSSTGDNKEGEEVSVIHYDDNAISKLLDRSQDATEDTEIQNMNEYL 1288

  Fly   801 SSFKVASYATKEDHEEHD---DYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIM 862
            ||||||.|..:|:..|.:   :.....||.||.|||.|:           :...:|.|.|:...:
Zfish  1289 SSFKVAQYVVREEDGEEEVQREIIKQEENVDPDYWEKLL-----------RHHYEQQQEDLARNL 1342

  Fly   863 GKGKRIRKEIDYSN 876
            ||||||||:::|::
Zfish  1343 GKGKRIRKQVNYND 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	28/76 (37%)
		CHROMO	181..233	CDD:214605	20/69 (29%)
		SNF2_N	270..561	CDD:278600	200/295 (68%)
		DEXDc	288..440	CDD:238005	101/156 (65%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
chd5	XP_009304380.1	CHDNT	159..208	CDD:285335
		PHD1_CHD_II	353..395	CDD:277006	4/15 (27%)
		PHD2_CHD_II	425..467	CDD:277007	27/41 (66%)
		CHROMO	500..553	CDD:214605	20/52 (38%)
		Chromo	600..651	CDD:278797	16/50 (32%)
		SNF2_N	710..1006	CDD:278600	200/295 (68%)
		DEXDc	727..885	CDD:238005	101/157 (64%)
		Helicase_C	1030..1145	CDD:278689	88/114 (77%)
		DUF1087	1301..1361	CDD:283996	21/67 (31%)
		DUF1086	1390..1530	CDD:283992
		BASP1	<1548..1692	CDD:283191
		CHDCT2	1758..1929	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920