DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and lds

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	183/781 - (23%)
Similarity:	320/781 - (40%)	Gaps:	214/781 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 VASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELS 205
            :.:.:|...|:|..:..|..|..|:          |...:|:..:|....|:..|:   .|.|||
  Fly   331 IDTLRRELAMDEQWISALRVQQSNV----------PAVRVVKPTLNPPRAPSIDTL---DWDELS 382

  Fly   206 YNDSSWERESDSIPGL----NQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLK 266
            ...:..:.......|:    ||.....:.|:..:...: |.|.|.:     ..:.||.||   :.
  Fly   383 EAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLE-DLPGPEV-----LAEDPVGLK---VS 438

  Fly   267 LHPFQIEGVSWLRYSWGQ-GIPT--ILADEMGLGKTIQTVVFLYSLFKEGH-------------- 314
            |...|...::|:  ||.: .:|.  ||||:||||||: |::......|.|.
  Fly   439 LMNHQKHALAWM--SWRERKLPRGGILADDMGLGKTL-TMISSVLACKNGQEMSEGKDESSDSDS 500

  Fly   315 ----------------------CRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTAR--A 355
                                  .||..|:..|.|.|..||.|:|             .|.:|  .
  Fly   501 EDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVE-------------SKVSRQKL 552

  Fly   356 VIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFI-----SVDAAFLGCIDWAALVVDEAHRLR 415
            .:..|..:..|...|.:|:      :::::|:|:.:     |:.|.|  .:.|..:::||||.:|
  Fly   553 TVCVHHGNNRETKGKYLRD------YDIVVTTYQIVAREHKSLSAVF--GVKWRRIILDEAHVVR 609

  Fly   416 SNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVK 480
            :::|:....:...|..|:..|||||:||...:::.||.||....|:||.|::....:.|...| .
  Fly   610 NHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ-N 673

  Fly   481 RLHEILEPHMLRRLKADV-----LKSMPPKSEFIVRVELSSMQKKFYKHILT------------- 527
            ||:.:::..||||.||.:     |.|:|.|...::.:.|...:...|:.::|
  Fly   674 RLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQR 738

  Fly   528 ------------KNFKALNQ---------------------KGGGRVCSLLNIMMDLRKCCNHPY 559
                        .|....||                     |...:...:|.:::.||:.|.||.
  Fly   739 AERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPG 803

  Fly   560 LF------------------------------------------------------PSAAEEATI 570
            |.                                                      |...:||.|
  Fly   804 LIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARI 868

  Fly   571 SPS--GLYEMS----SLTKASGKLDLLSKMLKQ--LKADNHRVLLFSQMTKMLNVLEHFLEGEGY 627
            :.:  .|.:.|    :|.:.|.|::::.::||.  ||:.:.:.::.||.|.:|::|...|..:|.
  Fly   869 AKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGV 933

  Fly   628 QYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQA 692
            ....::|:|....||..::.|||..::..|.|||..|||:|:||..|:.:::.|..|||..:.||
  Fly   934 ATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQA 998

  Fly   693 FSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRF 757
            ..|.:|:||||.|:||:|:..::||:||..:...|:.|...|:....  :::..:.|:|:.:  |
  Fly   999 QDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAK--VSSKLTIDDLKGL--F 1059

  Fly   758 G 758
            |
  Fly  1060 G 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991	0/5 (0%)
		CHROMO	181..233	CDD:214605	12/55 (22%)
		SNF2_N	270..561	CDD:278600	90/387 (23%)
		DEXDc	288..440	CDD:238005	46/196 (23%)
		Helicase_C	585..700	CDD:278689	39/116 (34%)
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	90/387 (23%)
		DEXDc	459..634	CDD:238005	46/196 (23%)
		HELICc	885..1014	CDD:238034	45/128 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467204
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840