DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and XNP

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_651398.1	Gene:	XNP / 43080	FlyBaseID:	FBgn0039338	Length:	1311	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	231/1011 - (22%)
Similarity:	377/1011 - (37%)	Gaps:	361/1011 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SFQRR--------SDMEEPSLEELDDQD----GNLHERFYRYG--IKPEWLLVQRVINHSEEPNG 193
            |.|||        ||.|.|:.||.::::    |:..|......  :.|:   .:|....||...|
  Fly   280 SRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQ---RKRRRKKSESDKG 341

  Fly   194 GTMY------LVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLN-- 250
            .:.:      ..|.|:.....||.|.:.|....           :..||.:...:...|.||:
  Fly   342 SSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDD-----------KQKNKRKHIRKIIKTKDLDLT 395

  Fly   251 ------------KKYEDQP-----VFLK------------------------EAGL--KLHPFQI 272
                        |:.||:.     :|:|                        :.||  ||.|.|:
  Fly   396 TKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQV 460

  Fly   273 EGVSWLRYSW--------------GQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRG--PFLI 321
            .||   ::.|              |.|  .|||..||||||:|.|...::|.......|  ..||
  Fly   461 AGV---KFMWDACFETLKESQEKPGSG--CILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLI 520

  Fly   322 SVPLSTLTNWERELELWAPELYCVTYVGGKTA-RAVIRKHEIS-FEEVTTKTMRENQTQYKFNVM 384
            ..||||:.||.||...|.           |.| |..|..::|| :::..|:..:.|:...:..|.
  Fly   521 ISPLSTVNNWAREFTSWM-----------KFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVC 574

  Fly   385 LTSYEFISV--------------DAAFLGCIDWA--ALVVDEAHRLRSNQSKFFRILSKYRIGYK 433
            :..|:...:              :......:|..  .:|.||.|.|::.::...:.:::.|...:
  Fly   575 ILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRR 639

  Fly   434 LLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQ------------AEFTDVSKEEQVKR----- 481
            ::||||||||||.|.:.::.|:   |.|.|.|::            .::|| |.|..::.
  Fly   640 IVLTGTPLQNNLREYYCMIQFV---KPNLLGTYKEYMNRFVNPITNGQYTD-STERDLRLMKHRS 700

  Fly   482 --LHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGG---GRV 541
              ||::||..:.||..:.:...:|||.|::|...||.:|:|.|.:.:|.:   ..|.||   |:.
  Fly   701 HILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTH---REQSGGDVVGKG 762

  Fly   542 CSLLNIMMDLRKCCNHP-------------------------YLFPSAAE-EATISPSGLYE--- 577
            ..|.....|||:...||                         ::.....| ||..:.|...|
  Fly   763 ARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFK 827

  Fly   578 ----MSSLTKASG---------------------------------------------------- 586
                ||.|..:||
  Fly   828 SDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELN 892

  Fly   587 ------KLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFL------------EGE-------- 625
                  ||.:|.::|:|.:|...::|:|||..:.|:|:||||            ||:
  Fly   893 NVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCW 957

  Fly   626 --GYQYDRIDGSIKGDLRQKAIDRFNDPVS-EHFVFLLSTRAGGLGINLATADTVIIFDSDWNPH 687
              |..|.|:|||...:.|:....:||:..: ...:||:|||||||||||..|:.|:|||..|||.
  Fly   958 TSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPS 1022

  Fly   688 NDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERI-----------------MQVAKH-----KMML 730
            :|.|:..|.:|.||.|...|||.:...::|:::                 .|:::|     .|.|
  Fly  1023 HDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMEL 1087

  Fly   731 THLVVRPGMGGMTTNFSKDEL-EDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKES 794
            ....::|..........||.| .:||....:.:||       :::..::.:..:..|...||::|
  Fly  1088 YSYELKPSTEREMPILPKDRLFAEILTEHEKLIFK-------YHEHDSLLEQEEHENLTEEERKS 1145

  Fly   795 -W------------ANEYLS----------------------SFKVASYAT-----------KED 813
             |            |::|:|                      |.|:..:.:           .:|
  Fly  1146 AWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKD 1210

  Fly   814 HEEHDDYN-------------NDAENTDPFYWENLM 836
            |:|.:...             |:..|.||..:::|:
  Fly  1211 HQELNQNQVIQLVPTYLQQLYNEMNNGDPTMYKDLL 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991	2/3 (67%)
		CHROMO	181..233	CDD:214605	10/57 (18%)
		SNF2_N	270..561	CDD:278600	94/371 (25%)
		DEXDc	288..440	CDD:238005	44/171 (26%)
		Helicase_C	585..700	CDD:278689	54/195 (28%)
XNP	NP_651398.1	DTHCT	258..335	CDD:285332	14/57 (25%)
		SNF2_N	458..779	CDD:278600	92/343 (27%)
		DEXDc	483..646	CDD:238005	45/175 (26%)
		Helicase_C	913..1035	CDD:278689	46/121 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467208
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840