DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Ino80

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster

Alignment Length:	1242	Identity:	281/1242 - (22%)
Similarity:	425/1242 - (34%)	Gaps:	504/1242 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCS--DGGDLLCCDSCPSVYHRTCLSPPLKSIP 70
            |.:..|.|:.:|.:|.:.|......|.....::.|  :.|.|   ....|..|:..|:
  Fly   284 DVEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSKKESGRL---QRIKSNNHKEMLA------- 338

  Fly    71 KGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKR--REYFIKWHGMSYWHCEWIPEGQM 133
                   .|..:.|...|::..|....:.:...|....||  ||.      ::||
  Fly   339 -------NCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREM------LAYW---------- 380

  Fly   134 LLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQ---------------- 182
              .....|...|||.  :|...||...||..|.| ..|...|..:|:.|
  Fly   381 --KRYERVERDQRRK--QEREAEEQRKQDVELIE-VKRQQRKLNFLITQTELYAHFMSKKLGQGS 440

  Fly   183 -----RVINH-SEEPN----------GGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKL 231
                 |:::. .||.|          .|.|.|:.....   :::.:|:.|.    .:|..::.|.
  Fly   441 EEDQLRILSQLDEETNARLAAQDDYDAGEMKLLAQENA---EAAMQRDLDK----TRAFDVFAKK 498

  Fly   232 RSSNKGRQRD------RPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTIL 290
            :...:..|..      :|.|..::  |...||...|..   |..:||:|::||...:.|||..||
  Fly   499 KEKEEEEQAQESVEDIKPEPRPEM--KDLPQPKMFKGT---LKGYQIKGMTWLANIYDQGISGIL 558

  Fly   291 ADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARA 355
            |||||||||:|::.||..:.:.....||||:..|.|||.||::|:..:.|:...|.|.|....|.
  Fly   559 ADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERK 623

  Fly   356 VIR-----KHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLR 415
            ::|     ||      :.|:       ...|:|::|||:.:..|..:...|.|..:|:|||..::
  Fly   624 ILRQFWDQKH------LHTR-------DASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIK 675

  Fly   416 SNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFL------SSGKFN-----DLQTFQAE 469
            |..|:.:::|..:....:|||:|||:||::.||:.||:|:      |..:||     |:::....
  Fly   676 SAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAEN 740

  Fly   470 FTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALN 534
            .|.:. |:|:.|||.||:|.||||:|.||...:..|.|.:|...|:..||..|        :||.
  Fly   741 KTGID-EKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLY--------RALK 796

  Fly   535 QK-----------------GGGRVCSLLNIMMDLRKCCNHPYLF--------------------- 561
            ||                 ......:|:|::|..||.||||.||
  Fly   797 QKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRL 861

  Fly   562 -----------PS---------------------------------------------------- 563
                       ||
  Fly   862 IHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGL 926

  Fly   564 --------------------------------------------------------------AAE 566
                                                                          .|.
  Fly   927 IDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTAN 991

  Fly   567 EATISPSGLY---------------------------EMSSLTKA-------------------- 584
            |:::...|.|                           ||..::|.
  Fly   992 ESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVK 1056

  Fly   585 ----------------------------------------------------------------- 584

  Fly  1057 VTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENS 1121

  Fly   585 ---------------------------------SGKLDLLSKMLKQLKADNHRVLLFSQMTKMLN 616
                                             :|||.:|..:|.:|||:.||||::||||||::
  Fly  1122 QGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMID 1186

  Fly   617 VLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFD 681
            :||.::....::|.|:|||.|...|:..:..|... ::.||||||||||||||||..|||||.:|
  Fly  1187 LLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTR-ADIFVFLLSTRAGGLGINLTAADTVIFYD 1250

  Fly   682 SDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNF 746
            |||||..|.||..||||:||.|:|.:||.:...::||||:|.|:.|..:..:|:..|      ||
  Fly  1251 SDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGG------NF 1309

  Fly   747 SKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATK 811
            ..|.|:                     ..:.|:.|||  :..||.|.....:..||..:.:....
  Fly  1310 KPDTLK---------------------PKEVVSLLLD--DEEIEMKYRQEAKLQSSSPIPAATQS 1351

  Fly   812 EDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQ----------KKQSQQSQVDVESIMGKGK 866
            |....|                          |:|.          ...:|....||.|.....|
  Fly  1352 ERKRRH--------------------------PQKDVNMGGTTIAATSATQNPDDDVPSCSSAAK 1390

  Fly   867 RIRKEID 873
            ||:.|.:
  Fly  1391 RIKLETE 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/43 (14%)
		CHROMO	85..147	CDD:237991	11/63 (17%)
		CHROMO	181..233	CDD:214605	12/83 (14%)
		SNF2_N	270..561	CDD:278600	110/323 (34%)
		DEXDc	288..440	CDD:238005	53/156 (34%)
		Helicase_C	585..700	CDD:278689	62/114 (54%)
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	32/162 (20%)
		SNF2_N	538..840	CDD:278600	110/323 (34%)
		DEXDc	555..700	CDD:238005	53/157 (34%)
		Helicase_C	1156..1269	CDD:278689	62/113 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467192
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930