DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and CG10445

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	957	Identity:	188/957 - (19%)
Similarity:	331/957 - (34%)	Gaps:	346/957 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 IPLPGKAEKILSWR--WALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVA 142
            :|:|..:.:|.:|.  ..:| |:||.....:.....|:   ..|.::.:.....|::   ..::.
  Fly    25 VPVPDSSGEINNWMEPEPVD-SLELSGEYADNESAIFV---SASEYNEKKAQIDQLV---QKILT 82

  Fly   143 SFQRRSDMEEPSLE--ELDDQDGNLHERFYRYGIKPEWLLVQR---------------VINHSEE 190
            ..|::..:||.:.|  ||.|...:|.:...|.....|:|...|               :::|:|:
  Fly    83 MEQQQRQLEENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKIEDNSELVDHTEQ 147

  Fly   191 PNGGTMY--LVKWRELSYNDSS--WERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNK 251
            |....:|  |.::|:.:.:.::  ::.:|:.|..|.   .||:.:          :|.|.||
  Fly   148 PKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLK---TLYEPI----------QPRPAID--- 196

  Fly   252 KYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIP-TILADEMGLGKTIQTVVFLYSL------ 309
            ..|.||..|.   ::|...|...:.|:::...|.|. .||||:||||||:..:..:.:.
  Fly   197 DLEKQPALLL---VRLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEETKNR 258

  Fly   310 ----------------FKEGHCR------------------------------------------ 316
                            |...:|:
  Fly   259 KREEKKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRIL 323

  Fly   317 -----------------------------------------GPF-----LISVPLSTLTNWEREL 335
                                                     |.:     |:..|:|.:..|..|
  Fly   324 DDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVMCQWAHE- 387

  Fly   336 ELWAPELYCVTYVGGKTARAVIR--------KHEISFEEVTTKTMRENQTQYKFNVMLTSYEFIS 392
                        |..|.|:..||        :|||..|...:           :::::|||..:.
  Fly   388 ------------VASKVAQNAIRVLTFHGPNRHEIGIEAFRS-----------YDLVITSYNLVV 429

  Fly   393 VDAAFLG------CIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHL 451
            .:....|      .:.|..:::||||.:|::::.....:.:.|......|||||:||...::|.|
  Fly   430 NELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFAL 494

  Fly   452 LNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKS--MP----------- 503
            |.|::...|.|||.::....:.....  :||:.|::|.||||.|..:..|  ||
  Fly   495 LRFVNVPNFQDLQQWKKNLNESMLGH--RRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELIC 557

  Fly   504 ---PKSEFIVRVELSSMQKKF-----------------------------------YKHILTKNF 530
               .|:|..|...||::.||.                                   |..|..:..
  Fly   558 VQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFL 622

  Fly   531 KALNQKGGGRVCS--LLNIMMDLRKCCNHPYLF------PSAAEEA------------------- 568
            |:|....|.::..  :|.:::.||:.|.||.|.      ...||:.
  Fly   623 KSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVL 687

  Fly   569 --------TISPSGLYEMSSLTKASG--KLDLLSKMLKQ-------------------------- 597
                    |.|.....:....|:..|  ||:::...:|:
  Fly   688 AELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARA 752

  Fly   598 ------------------------------LKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRI 632
                                          |...|.::::.||....|.::...|:...::....
  Fly   753 LKLLNPQNPIFQFIRPSAKLKMVIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQDLSWETLDF 817

  Fly   633 DGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAH 697
            :|.:....|:..:..|| ..:|..|.|||..|||:|:||..|:.::|.|..|||..:.||..|.:
  Fly   818 NGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIY 881

  Fly   698 RMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTT 744
            |.||.|...|||::..::||:||..:...|:.:.. ||.|..||..|
  Fly   882 RYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAK-VVLPEEGGEVT 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991	10/63 (16%)
		CHROMO	181..233	CDD:214605	12/70 (17%)
		SNF2_N	270..561	CDD:278600	87/468 (19%)
		DEXDc	288..440	CDD:238005	41/275 (15%)
		Helicase_C	585..700	CDD:278689	35/172 (20%)
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	176/885 (20%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	64/350 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467132
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840