DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Etl1

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_609320.2	Gene:	Etl1 / 34311	FlyBaseID:	FBgn0032157	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	235/743 - (31%)
Similarity:	351/743 - (47%)	Gaps:	161/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DDQDGNL-------HERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELS-YNDSSWERES 215
            ||.|..:       .::.:::..:...:.:|.|...||:.   .:.::..|..| ::|...:.||
  Fly   170 DDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKK---ALAIIDVRPFSDWSDLRQKLES 231

  Fly   216 DSIPG--LNQAIALYKKLRS-----SNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIE 273
            ..:.|  ||.|..|..|..:     |.......|....|.......:||..| .:||:|..:||.
  Fly   232 IRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLL-SSGLQLADYQII 295

  Fly   274 GVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELW 338
            |::||.....|.:..|||||||||||||.:.||..|.:.|..:...||.||.|||.|||.|:..|
  Fly   296 GLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRW 360

  Fly   339 APELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVD----AAFLG 399
            .|||....|.|.:..|..:|          .:..::..|  .|:|:||:|..:...    ..|..
  Fly   361 CPELVVEKYHGSQDERRRMR----------GRFAKDGFT--GFDVLLTTYHIVGSTPEERKMFRV 413

  Fly   400 C-IDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFL-------- 455
            | :|:  ::.||||.|::..::.:..|.......::|||||||||||.||..||.|:
  Fly   414 CKLDY--VIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKS 476

  Fly   456 -------------SSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSE 507
                         |.|..:::..||        |.|::|...|::|.:|||||.||||::|.|..
  Fly   477 IEDIKSLFAKKGKSDGDQDEVSQFQ--------ETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLS 533

  Fly   508 FIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSL-----LNIMMDLRKCCNHP--------- 558
            .:.:|.:||.||.:| |.|...:.  |.|  |.|||.     :.|||::|:..|||
  Fly   534 LVEKVPMSSQQKIYY-HELVDYYS--NNK--GEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTD 593

  Fly   559 ----------------------YLFPSAAEEATISPSGLYEM------------SSLTKASGKLD 589
                                  |:|   .|.|.:|...:|:|            .:|...|||..
  Fly   594 ANLRGFSKRLANASSFKKTNEQYIF---EELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFL 655

  Fly   590 LLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFN--DPV 652
            .|..:|.:|||:.||||||||.|.||:::|.:|....:.:.|:||:...::||..|..||  |.:
  Fly   656 YLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSI 720

  Fly   653 SEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVE 717
               |||||||:|||:||||..|||.:|.|.|:||:||.||..|.|||||::.|.|||.::.:::|
  Fly   721 ---FVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIE 782

  Fly   718 ERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLL 782
            |.|:..|:.|:.|                            .:|:..:.|.|.  ::.:.|..||
  Fly   783 EGILMAAEEKLKL----------------------------EKDITSNEKGEV--HEQRCVVKLL 817

  Fly   783 DRTNRGIE-EKESWANEYLSSFKVASYA 809
             .|..|:: ::|...|..|:: .:||.|
  Fly   818 -TTALGLDKDQEEQLNNSLNN-SIASPA 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991
		CHROMO	181..233	CDD:214605	15/54 (28%)
		SNF2_N	270..561	CDD:278600	115/352 (33%)
		DEXDc	288..440	CDD:238005	55/156 (35%)
		Helicase_C	585..700	CDD:278689	59/116 (51%)
Etl1	NP_609320.2	SNF2_N	292..587	CDD:278600	114/321 (36%)
		DEXDc	308..453	CDD:238005	55/158 (35%)
		Helicase_C	651..765	CDD:278689	59/116 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467146
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840