DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Marcal1

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	160/727 - (22%)
Similarity:	268/727 - (36%)	Gaps:	202/727 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 EEPNGG----------------------------TMYLVKWRELSYNDSSWERESDSIPGLNQAI 225
            :.||||                            .:||:.....:...|.:.         .|.:
  Fly   117 QRPNGGNERNKPTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYH---------EQLV 172

  Fly   226 ALYKKLRS------------------SNKGRQRDRPAPTIDLN---KKYED---QPVFLKEAGL- 265
            .::|.:.:                  |.|....|. .|.:.:|   ||..|   ||..:.|..:
  Fly   173 TVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADL-KPYVHMNGIPKKVLDLCGQPPVVPERSVL 236

  Fly   266 ---------KLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLI 321
                     :|.|||.:||.:.....|:   .::.||||||||.|.:. :...||:.   .|.|:
  Fly   237 ASIEPKLADQLMPFQQDGVCFAIAQKGR---IMICDEMGLGKTYQALA-VADYFKDD---WPLLV 294

  Fly   322 SVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLT 386
            ....||..:|.:.:....|:: .:.||      .|:..:::...|.              .|::|
  Fly   295 CTTASTRDSWAKHIMDLLPKV-PIHYV------QVLNNNQLYVGEA--------------KVLIT 338

  Fly   387 SYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYK--LLLTGTPLQNNLEELF 449
            ||..:......|....:..::.||:|.|:::::|......:.....|  :||:|||..:...|||
  Fly   339 SYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELF 403

  Fly   450 HLLNFLSSGKFNDLQTFQAEFT---------DVSKEEQVKRLHEILE-PHMLRRLKADVLKSMPP 504
            ..|..: .|||.:...|...:.         |.:.:..::.|..||. .:||||.|.:||..:..
  Fly   404 TQLQMI-DGKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAE 467

  Fly   505 KS-EFIV--------RVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYL 560
            |: |.:|        ..|.......|.|.:.|..         ||
  Fly   468 KNRETVVLDPALVWTNAETKETLDAFNKELKTAK---------GR-------------------- 503

  Fly   561 FPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGE 625
               |.||..:.   .|..::..|.......|..::|:.|    :.::|:....|::.:..||.|.
  Fly   504 ---ATEEILLR---FYARTAEVKTRAVCAYLKTLVKEQK----KFIIFAHHRVMMDAISDFLSGL 558

  Fly   626 GYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDV 690
            ...|.||||..:.|.|..::|.|... |...|.|||.:|...||.|..|:.::..:.||||....
  Fly   559 KVHYIRIDGQTRSDHRSDSVDTFQKK-SSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLA 622

  Fly   691 QAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDIL 755
            ||.|||||:||.|.|:....:.||:.::.|..:.|:|.                       |.:.
  Fly   623 QAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQ-----------------------EVLS 664

  Fly   756 RFGTEDLFKDGKSEAIHYDDKAVADLLDR-----TNRGIEEKESWANEYLSSFKVASYATKEDHE 815
            :.|   :|.:...:|.|......:..::.     |:..:|.:.:...:|.|:.     ..||..|
  Fly   665 KVG---IFAENLQKATHTAAPTSSHKIEEYFSPSTSTSLEPERNSIKQYFSTI-----PAKEPPE 721

  Fly   816 EHDDYNNDAENT 827
            :    ||:.|.|
  Fly   722 Q----NNNTEMT 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991
		CHROMO	181..233	CDD:214605	9/71 (13%)
		SNF2_N	270..561	CDD:278600	70/311 (23%)
		DEXDc	288..440	CDD:238005	35/153 (23%)
		Helicase_C	585..700	CDD:278689	38/114 (33%)
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	7/64 (11%)
		DEXDc	239..420	CDD:214692	51/209 (24%)
		DEXDc	265..394	CDD:238005	35/153 (23%)
		Helicase_C	518..632	CDD:278689	39/118 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840