Protein Alignment Chd3 and Chd7

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 954
• Identity: 343/954 - (35%)
• Similarity: 504/954 - (52%)
• Gaps: 170/954 - (17%)

  Fly     2 SSKRGAD--PD------------WKTPGKASKD---------------------KRPKTNAKKQK 31
            |||:.::  ||            .||.|..:.|                     :|.....|:::
Mouse   684 SSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPAPEEDEDPGVQKRRSSRQVKRKR 748

  Fly    32 FRDEEYCKVC---SDGGDLLCCDSCPSVYHRTCLSPPLKSI-PKGDWICPRCIPLPGKAEKILSW 92
            :.::...|:.   :|..|....|| ||   .|..|...:|: .:|..:           |||:|
Mouse   749 YTEDLEFKISDEEADDADAAGRDS-PS---NTSQSEQQESVDAEGPVV-----------EKIMS- 797

  Fly    93 RWALDRSVELRTSKGE--KRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSL 155
                .|.|:.:...||  :..|:::|:...||.||:|                         .|:
Mouse   798 ----SRLVKKQKESGEEVEVEEFYVKYKNFSYLHCQW-------------------------ASV 833

  Fly   156 EELDDQDGNLHERFYRYGIK----------------PEWLLVQRVIN--HSEEPNGGTM--YLVK 200
            |:| ::|..:.::..|:..|                |:::.|.|:::  .|.:..|..:  ||||
Mouse   834 EDL-EKDKRIQQKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDFARSTDDRGEPVIHYLVK 897

  Fly   201 WRELSYNDSSWERESDSIPGLNQA-IALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAG 264
            |..|.|.||:||.:.|    ::|. |..::||.|.....:|....|..|. ||.|....:  :..
Mouse   898 WCSLPYEDSTWELKQD----IDQTKIEEFEKLMSREPETERVERPPADDW-KKSESSREY--KNN 955

  Fly   265 LKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLT 329
            .||..:|:|||:||.::|......|||||||||||||::.|||.::.:| ..||||:..||||:.
Mouse   956 NKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKG-IHGPFLVIAPLSTIP 1019

  Fly   330 NWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVD 394
            |||||...|. ||..|.|.|.:.:|..|:.:|:.|::...:.::.:   |||:.::|::|.|..|
Mouse  1020 NWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGS---YKFHAIITTFEMILTD 1080

  Fly   395 AAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGK 459
            ...|..|.|..:|:||||||::...|....|....:.:|:|||||||||.:||||.||:||...:
Mouse  1081 CPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSR 1145

  Fly   460 FNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKH 524
            |....||..||.|:..||||::|..||:|.||||||.||.|::.||.|.|:.|||:::|||:|:.
Mouse  1146 FPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRA 1210

  Fly   525 ILTKNFKALNQKGGGR--VCSLLNIMMDLRKCCNHPYLFPSAAE-------EATISPSGLYEMSS 580
            ||.|||..|: ||||:  |.:|||.||:||||||||||...|.|       |...:.|..:::.:
Mouse  1211 ILEKNFTFLS-KGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQA 1274

  Fly   581 LTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAI 645
            :.:|:|||.|:.|:|.:|||..||||:||||.:.|::||.:|....|.|:||||.::|:|||.||
Mouse  1275 MIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAI 1339

  Fly   646 DRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRF 710
            |||:.|.|:.|||||.||||||||||..|||.|||||||||.||:||.:|.||:||.|.|.|||.
Mouse  1340 DRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRL 1404

  Fly   711 VTHNSVEERIMQVAKHKMMLTHLVVRPGMGGM--TTN----FSKDELEDILRFGTEDLFKDGKSE 769
            :|.||.|..:...|..|:.|...|:: .|.|.  .||    .||.|:||:||.|......|.:.|
Mouse  1405 ITRNSYEREMFDKASLKLGLDKAVLQ-SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDE 1468

  Fly   770 AIHYDDKAVAD-LLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFYWE 833
            ...:.::.:.. ||.||:....|.|...    |:|..||:....:       ..|....||.:|:
Mouse  1469 GSKFCEEDIDQILLRRTHTITIESEGKG----STFAKASFVASGN-------RTDISLDDPNFWQ 1522

  Fly   834 NLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGK------RIRKE 871
                           |.::::::|::::.|:..      |:||:
Mouse  1523 ---------------KWAKKAELDIDALNGRNNLVIDTPRVRKQ 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	11/45 (24%)
		CD_CSD	82..146	CDD:475127	15/65 (23%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	19/58 (33%)
		PLN03142	266..>768	CDD:215601	251/516 (49%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792		22/111 (20%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	21/105 (20%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	20/60 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		6/21 (29%)
		PLN03142	957..>1556	CDD:215601	272/628 (43%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986