DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd2

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_038968738.1	Gene:	Chd2 / 308738	RGDID:	1310056	Length:	1840	Species:	Rattus norvegicus

Alignment Length:	881	Identity:	346/881 - (39%)
Similarity:	492/881 - (55%)	Gaps:	136/881 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPE---GQMLLHHASMVASFQRRSDMEEPSLEEL 158
            |.|.:..|.:.|...:|.|||.|.||.|..|..|   .|..:.....:.:|:::.|..:..|.::
  Rat   304 DPSGDFDTEREEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKV 368

  Fly   159 DDQDGNLH--ERFYRYGIKPEWLLVQRVI---------------NHSEE--PNGGTMYLVKWREL 204
            ..:|....  ::.....:..::.:|:|||               .||.:  |:....||.||..|
  Rat   369 SPEDVEYFNCQQELASELNKQYQIVERVIAVKTSKSALGQTDFPAHSRKPAPSNEPEYLCKWMGL 433

  Fly   205 SYNDSSWERESDSIPGLNQAIALYKKLRS---SNKGRQRDRPAPT------------IDLNKKYE 254
            .|::.|||.|:          .:.||.:|   |...|...:..||            :.|.|
  Rat   434 PYSECSWEDEA----------LIGKKFQSCIDSFHSRNNSKTIPTRECKALKQRPRFVALKK--- 485

  Fly   255 DQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPF 319
             ||.:|....|:|..:|:||::||.:||.:....||||||||||||||:.||..||.:....|||
  Rat   486 -QPAYLGGENLELRDYQLEGLNWLAHSWCKSNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPF 549

  Fly   320 LISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVM 384
            ||.|||||||:|:||.|:||||:..|.|:|...:|..||:    :|.:.::|.|     .|||.:
  Rat   550 LIVVPLSTLTSWQREFEIWAPEVNVVVYIGDLMSRNTIRE----YEWIHSQTKR-----LKFNAL 605

  Fly   385 LTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELF 449
            :|:||.:..|...||.|:||.|.|||||||:::.|..::.|..::..::||:|||||||:|:||:
  Rat   606 ITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELW 670

  Fly   450 HLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVEL 514
            .||:|:...||...:.|: |.....:|...:.||::|||.:|||:|.||.||:|.|.|.|:|||:
  Rat   671 SLLHFIMPEKFEFWEDFE-EDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEM 734

  Fly   515 SSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLF--PSAAEEATISPSGLYE 577
            |::||::||.|||:|:|||.:...|.....|||:|:|:|||||.||.  |..:|..|    |...
  Rat   735 SALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIRAPEDSERET----GQEV 795

  Fly   578 MSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQ 642
            :.||.::||||.||.|:|.:|:...:|||:||||.:||::|..:|..:.|.:.|:||||||::|:
  Rat   796 LQSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRK 860

  Fly   643 KAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMI 707
            :|:|.||...||.|.|||||||||||||||:||||:||||||||.||:||.:||||:||||:|.|
  Rat   861 QALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNI 925

  Fly   708 YRFVTHNSVEERIMQVAKHKMMLTHLVVR-----------PGMGGMTTN-FSKDELEDILRFGTE 760
            ||.||..:|||.|::.||.||:|.|||::           ...|...:| |:|:||..||:||.|
  Rat   926 YRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTVLENNSGRSNSNPFNKEELTAILKFGAE 990

  Fly   761 DLFKDGKSEAIHYDDKAVADLL----DRTNRGIEEKESWANEYLSSFKVASYATKEDHEE----- 816
            ||||:.:.|.....:..:.::|    .|.|   |...|..:|.||.||||::||.||.||
  Rat   991 DLFKEIEGEESEPQEMDIDEILRLAETREN---EVSTSATDELLSQFKVANFATMEDEEELEERP 1052

  Fly   817 HDDYNNDAENTDPFYWENLMGKSQPK----------------LPK----KQKKQSQQSQVDVESI 861
            |.|            |:.::.:.|.|                ||:    .:|.|:..|..|.||
  Rat  1053 HKD------------WDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTES- 1104

  Fly   862 MGKGKR-------IRKEIDYSNQYPSP-NRATPSSI 889
                ||       ...|.|.|:....| .|..|.|:
  Rat  1105 ----KRQAQRSSASESETDDSDDDKKPKRRGRPRSV 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991	16/52 (31%)
		CHROMO	181..233	CDD:214605	19/68 (28%)
		SNF2_N	270..561	CDD:278600	140/290 (48%)
		DEXDc	288..440	CDD:238005	73/151 (48%)
		Helicase_C	585..700	CDD:278689	71/114 (62%)
Chd2	XP_038968738.1	CD1_tandem_CHD1-2_like	272..356	CDD:349313	16/51 (31%)
		CD2_tandem_CHD1-2_like	389..460	CDD:349308	21/80 (26%)
		DEXHc_CHD2	477..713	CDD:350812	109/249 (44%)
		PLN03142	481..>1034	CDD:215601	271/573 (47%)
		CDH1_2_SANT_HL1	1143..1231	CDD:408175
		DUF4208	1484..1566	CDD:404744
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910