DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd1

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001100935.1	Gene:	Chd1 / 308215	RGDID:	1306794	Length:	1711	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	343/978 - (35%)
Similarity:	524/978 - (53%)	Gaps:	172/978 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKRGADPDWKTPGKASKDKRPKTNAKK--------QKFR---------DEEYC----------- 38
            ||..|.:.|::...|. |.::|:..:|.        ||.|         ||:|.
  Rat   172 SSCDGTESDYEPKNKV-KSRKPQNRSKSKSGKKILGQKKRQIDSSEDEDDEDYDNDKRSSRRQAT 235

  Fly    39 ---------KVCSDGGDLL--CCDSCPSVYHRTCLSPPLKSIP---------KGDWICPRCIPLP 83
                     ::.:|..|||  |.:..|...     ....::|.         ||         ..
  Rat   236 VNVSYKEDEEMKTDSDDLLEVCGEDVPQTE-----DEEFETIERFMDCRVGRKG---------AT 286

  Fly    84 GKAEKILSWRWALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPE---GQMLLHHASMVASFQ 145
            |....|.:.....|.:.....||.....:|.|||.|.|:.|..|..|   .|..:.....:.:::
  Rat   287 GATTTIYAIEADGDPNAGFEKSKEPGDVQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYK 351

  Fly   146 RRSDMEEPSLEELDDQD-----------GNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTM--Y 197
            ::....:..|:....:|           .:||:::.         :|:|:|.||.:.:...:  |
  Rat   352 KKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQ---------IVERIIAHSNQKSAAGLPDY 407

  Fly   198 LVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRS---SNKGRQRDRPAPTIDLNKKYEDQPVF 259
            ..||:.|.|::.|||          ....:.||.::   ....|.:.:..|..|. |..:.:|.|
  Rat   408 YCKWQGLPYSECSWE----------DGALISKKFQTCIDEYFSRNQSKTTPFKDC-KVLKQRPRF 461

  Fly   260 --LKE--------AGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGH 314
              ||:        .||:|..:|:.|::||.:||.:|...||||||||||||||:.||..||.|..
  Rat   462 VALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQ 526

  Fly   315 CRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQY 379
            ..||||:.|||||||:|:||::.||.::..|.|:|...:|.:||.||         .|.....:.
  Rat   527 LYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHE---------WMHPQTKRL 582

  Fly   380 KFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNN 444
            |||::||:||.:..|.||||.::||.:.|||||||:::.|..::.|..::..::||:|||||||:
  Rat   583 KFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNS 647

  Fly   445 LEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFI 509
            |:||:.||:|:...||:..:.|:.|. ...:|.....||:.|||.:|||:|.||.||:|.|.|.|
  Rat   648 LKELWSLLHFIMPEKFSSWEDFEEEH-GKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQI 711

  Fly   510 VRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSG 574
            :|:|:|::||::||.|||:|:|||::...|.....|||||:|:|||||.||         |.|..
  Rat   712 LRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYL---------IKPPD 767

  Fly   575 LYE-------MSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRI 632
            ..|       :..|.::||||.||.|:|.:|:...:|||:||||.:||::|..:|:...:.:.|:
  Rat   768 NNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRL 832

  Fly   633 DGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAH 697
            ||||||:||::|:|.||...||.|.|||||||||||||||:||||:||||||||.||:||.:|||
  Rat   833 DGSIKGELRRQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAH 897

  Fly   698 RMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVV-RPGMGGMT-----------TNFSKDE 750
            |:||||:|.|||.||..||||.|::.||.||:|.|||: |....|.|           |.|:|:|
  Rat   898 RIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEE 962

  Fly   751 LEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKE----SWANEYLSSFKVASYATK 811
            |..||:||.|:|||:.:.|.....:..:.::|.|..  ..|.|    :..:|.||.||||:::..
  Rat   963 LSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAE--THENEPGPLTVGDELLSQFKVANFSNM 1025

  Fly   812 EDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKK--QSQQSQVDVESI--MGKGKRIRKEI 872
            ::.:...:...:::|     ||::       :|::|::  :.::.|.::|.|  :.:.:...|:|
  Rat  1026 DEDDIELEPERNSKN-----WEDI-------IPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQI 1078

  Fly   873 DYS 875
            .::
  Rat  1079 SFN 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	10/72 (14%)
		CHROMO	85..147	CDD:237991	14/64 (22%)
		CHROMO	181..233	CDD:214605	15/53 (28%)
		SNF2_N	270..561	CDD:278600	138/290 (48%)
		DEXDc	288..440	CDD:238005	71/151 (47%)
		Helicase_C	585..700	CDD:278689	71/114 (62%)
Chd1	NP_001100935.1	CD1_tandem_CHD1-2_like	268..352	CDD:349313	18/92 (20%)
		CD2_tandem_CHD1-2_like	385..441	CDD:349308	15/74 (20%)
		DEAD-like_helicase_N	458..695	CDD:421690	107/246 (43%)
		PLN03142	462..>998	CDD:215601	261/554 (47%)
		CDH1_2_SANT_HL1	1122..1208	CDD:408175
		PTZ00121	<1292..1574	CDD:173412
		DUF4208	1408..1498	CDD:404744
		PHA03420	1591..>1691	CDD:177648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910