DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd3

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_038943541.1	Gene:	Chd3 / 303241	RGDID:	1311923	Length:	2120	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	507/952 - (53%)
Similarity:	645/952 - (67%)	Gaps:	93/952 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RGADPDWKTPGKASKDKRPKTNAKKQKFRDE-------------EYCKVCSDGGDLLCCDSCPSV 56
            |..:..|..|....:..:.:...:::.:.:|             |||:||.|||:|||||:|.|.
  Rat   474 RAPEGKWSCPHCEKEGVQWEAKEEEEDYEEEGEEGEKEEEDDHMEYCRVCKDGGELLCCDACISS 538

  Fly    57 YHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWA-----------LDRSVEL---RTS 105
            ||..||:|||..||.|:|:||||.  .|.|:.:|||.|||.           .|...:.   |..
  Rat   539 YHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQADGDPDAPPPRVL 603

  Fly   106 KGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELD----DQDG--- 163
            :|...||:|:||.|:|||||.|..|.|:.:.|..|..::||::||:||  ..||    :.||
  Rat   604 QGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEP--PPLDYGSGEDDGKSD 666

  Fly   164 ----------NLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSI 218
                      .:.|::||:||||||:.|.|:||||.:..|...|||||::|.|:.|:||.:..:|
  Rat   667 KRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSMDKKGNYHYLVKWKDLPYDQSTWEEDEMNI 731

  Fly   219 PGLNQAIALY---------------KKLRSSNKGRQRDRP--APTIDLNKKYEDQPVFLKEAGLK 266
            |..:.....|               :|.:...|..|.|.|  :||.|...|||.||.|:...|..
  Rat   732 PEYDDHKQSYWRHRELIMGEDPAQPRKYKKKKKEIQGDGPPSSPTNDPTVKYETQPRFITATGGT 796

  Fly   267 LHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNW 331
            ||.:|:||::|||:||.||..|||||||||||||||:||||||:||||.:||||:|.||||:.||
  Rat   797 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINW 861

  Fly   332 ERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMR-----ENQTQYKFNVMLTSYEFI 391
            |||.::|||:.|.|||.|.|.:||:||::|.|||:...|..:     :.:.|.||:|:|||||.|
  Rat   862 EREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELI 926

  Fly   392 SVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLS 456
            ::|.|.||.|.||.|||||||||::|||||||:|:.|:|.:|||||||||||||||||||||||:
  Rat   927 TIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLT 991

  Fly   457 SGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKF 521
            ..:||:|:.|..||.|:|||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.||||:
  Rat   992 PERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKY 1056

  Fly   522 YKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASG 586
            ||:|||:||:|||.:|||...|||||||||:||||||||||.||.|:...|||.||..:|.|:||
  Rat  1057 YKYILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSG 1121

  Fly   587 KLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDP 651
            ||.||.|||::||...||||:||||||||::||.||:.|||:|:||||.|.|.|||:||||||.|
  Rat  1122 KLLLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAP 1186

  Fly   652 VSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSV 716
            .::.|.||||||||||||||||||||||||||||||||:||||||||:||..|||||||||..||
  Rat  1187 GAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASV 1251

  Fly   717 EERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGK--------SEAIHY 773
            ||||.||||.||||||||||||:|....:.||.||:|||:||||:||||..        |..|||
  Rat  1252 EERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHY 1316

  Fly   774 DDKAVADLLDRTNRGIEEKE-SWANEYLSSFKVASYATKED---HEEHDDYNNDAENTDPFYWEN 834
            |::|:|.||||.....::.: ...||||||||||.|..:|:   .|...:.....||.||.|||.
  Rat  1317 DNEAIARLLDRNQDATDDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEK 1381

  Fly   835 LMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSN 876
            |:           :...:|.|.|:...:|||||:||:::|::
  Rat  1382 LL-----------RHHYEQQQEDLARNLGKGKRVRKQVNYND 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	26/75 (35%)
		CHROMO	181..233	CDD:214605	21/66 (32%)
		SNF2_N	270..561	CDD:278600	197/295 (67%)
		DEXDc	288..440	CDD:238005	99/156 (63%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
Chd3	XP_038943541.1	CHDNT	203..256	CDD:400425
		TNG2	<384..488	CDD:227367	3/13 (23%)
		PHD1_CHD_II	443..485	CDD:277006	3/10 (30%)
		PHD2_CHD_II	519..561	CDD:277007	24/43 (56%)
		CD1_tandem_CHD3-4_like	566..644	CDD:349314	33/97 (34%)
		CD2_tandem_CHD3-4_like	689..743	CDD:349309	19/70 (27%)
		PLN03142	780..>1334	CDD:215601	352/570 (62%)
		DEXHc_CHD3	797..1028	CDD:350813	151/235 (64%)
		DUF1087	<1375..1418	CDD:399459
		DUF1086	1439..1578	CDD:368921
		PHA03169	<1570..>1761	CDD:223003
		CHDCT2	1799..1925	CDD:400426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4455
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	1	1.000	-	-		otm45407
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920