Protein Alignment Chd3 and Ttf2

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001099924.2
• Gene: Ttf2 / 295324
• RGDID: 1309145
• Length: 1142
• Species: Rattus norvegicus
• Alignment Length: 864
• Identity: 199/864 - (23%)
• Similarity: 334/864 - (38%)
• Gaps: 279/864 - (32%)

  Fly    59 RTCLSPPLKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVE-LRTSKGEKRREYFIKWHGMSY 122
            |..|:..||. .||.........||.|.||:|....||:.::. |..|..:..||
  Rat   393 RANLTTQLKQ-KKGTLAAVNIQALPDKGEKLLKQIQALEDALNALALSPEQGTRE---------- 446

  Fly   123 WHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDD--QDGNLH----ERFYRYGIKPEWLLV 181
             :|                       ..:||...::.:  ..|.||    :...|..|:|...|.
  Rat   447 -NC-----------------------SSQEPEQSKVTETAAAGPLHLVPPQPLPRPHIQPAASLG 487

  Fly   182 QRVINHSEEPNGGT-----------MYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSN 235
            .:. :..|.|.|.:           :|.| |:..|.......|..:|.|| ..|:|
  Rat   488 LKA-SRQETPEGASQCSGGHTNEHRLYNV-WKITSEAIDELHRSLESCPG-KTAVA--------- 540

  Fly   236 KGRQRDRPAPTIDLNKKYEDQPVFLKEAGLK----LHPFQIEGVSWLRYSWGQ----GIPTILAD 292
                              ||      .||||    ||  |.:.::||.:...|    |   ||||
  Rat   541 ------------------ED------PAGLKVPLLLH--QKQALAWLLWRESQKPQGG---ILAD 576

  Fly   293 EMGLGKTIQTVVFLYSLFKEGHCRGP-----------------------FLISVPLSTLTNWERE 334
            :||||||:..:..:  |.|:...:..                       .||..|.|.:.:|:.|
  Rat   577 DMGLGKTLTMIALI--LTKKNQQKSKEKDRSLPVMWLSKNDSSVFTSTGTLIVCPASLIHHWKNE 639

  Fly   335 LELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMR------ENQTQY-----KFNVMLTSY 388
            :|                            :.|.:..:|      .|:.|:     .:::::|:|
  Rat   640 IE----------------------------KRVNSNKLRIYLYHGPNRIQHAKVLSTYDIVITTY 676

  Fly   389 EFIS---------------------VDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGY 432
            ..::                     :.|..|..: ||.:::||||.:::.:.:....:.|.:...
  Rat   677 SLLAKEIPTAKHEGEVPGAKLSVEGISAPLLQVV-WARIILDEAHNVKNPRVQTSIAVCKLQAQA 740

  Fly   433 KLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKAD 497
            :..:||||:||||.:::.|:.||....|::...:::: .|....:..:||..:.:..:|||.| |
  Rat   741 RWAVTGTPIQNNLLDMYSLMKFLRCSPFDEFSLWKSQ-VDNGSMKGGERLSILTKSLLLRRTK-D 803

  Fly   498 VLKS-------MPPKSEFIVRVELSSMQKKFYKHILTKNFKAL-----NQKGGG----------- 539
            .|.|       :|.:|..:.|::||..::..|...|.::..||     .|:|.|
  Rat   804 QLDSTGKPLVPLPARSCQLHRLKLSEDERAVYDVFLARSRSALQSYLKRQEGRGSHPGRSPENPF 868

  Fly   540 -RV----------CS------------LLNIMMDLRKCCNHPYLFPSAAEEATISPSGLY----- 576
             ||          ||            :|:.::.||:||.|..|..|..:...:...||.
  Rat   869 SRVAQEFGSGVPQCSTAADSRRPSTVHVLSQLLRLRQCCCHLSLLKSVLDPKELESEGLVLSLEE 933

  Fly   577 EMSSLTKASGKLDL---------------------------LSKMLKQLKA-----DNHRVLLFS 609
            ::|:||.:  |:|:                           :|.:|.:|:|     .:.:.::.|
  Rat   934 QLSALTLS--KVDVSEPSPTVSLNGTCFKVELFDDIRRSTKVSSLLAELEAIQKGPGSQKSVIVS 996

  Fly   610 QMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATA 674
            |.|.||.|:...|......|..||||:....|...::.||...... |.|:|..|||:|:||...
  Rat   997 QWTSMLQVVALHLRKNRLTYATIDGSVNPKQRMDLVEAFNHSQGPQ-VMLISLLAGGVGLNLTGG 1060

  Fly   675 DTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGM 739
            :.:.:.|..|||..:.||..|.:|:||:|.|:::|||...:|||:|:|:.:.|..|...|: .|.
  Rat  1061 NHLFLLDMHWNPSLEDQACDRIYRVGQEKDVVMHRFVCEGTVEEKILQLQEKKKDLAKQVL-SGS 1124

  Fly   740 GGMTTNFSKDELEDILRFG 758
            ||..|..:..:|:  :.||
  Rat  1125 GGPVTKLTLADLK--ILFG 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/19 (32%)
		CD_CSD	82..146	CDD:475127	13/64 (20%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	15/64 (23%)
		PLN03142	266..>768	CDD:215601	153/639 (24%)
Ttf2	NP_001099924.2	zf-GRF	6..44	CDD:480736
		HepA	<536..1122	CDD:440319	153/660 (23%)
		DEXHc_TTF2	550..800	CDD:350830	57/286 (20%)