DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Chd3 and Phf21b

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001074635.2	Gene:	Phf21b / 271305	MGIID:	2443812	Length:	487	Species:	Mus musculus

Alignment Length:	168	Identity:	48/168 - (28%)
Similarity:	67/168 - (39%)	Gaps:	56/168 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKRGADPDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCPSVYHRTCLSPP 65
            ::::...||.||  |:.:.|               |:|..|..|..|..|.:|...||.:||.||
Mouse   290 LTARANEDPCWK--GEITHD---------------EFCAACKRGASLQPCGTCSGAYHLSCLDPP 337

  Fly    66 LKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKRREYFIKWHGM-----SYWHC 125
            ||:.|||.|:||:|            .|.||             :::..:.|.||     ||...
Mouse   338 LKTPPKGLWVCPKC------------QRKAL-------------KKDEGVPWTGMLAIVHSYVTH 377

  Fly   126 EWI--PEGQMLLHHASMVASFQRRSDMEEPSLEELDDQ 161
            :.:  .|.|.||...|.:.|       |...|||.|.|
Mouse   378 KTVKEEEKQKLLQRGSELQS-------EHQQLEERDRQ 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	20/41 (49%)
		CHROMO	85..147	CDD:237991	14/68 (21%)
		CHROMO	181..233	CDD:214605
		SNF2_N	270..561	CDD:278600
		DEXDc	288..440	CDD:238005
		Helicase_C	585..700	CDD:278689
Phf21b	NP_001074635.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..229
Phf21b	NP_001074635.2	PHD_SF	309..351	CDD:304600	20/41 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900