DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd5

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_006538992.1	Gene:	Chd5 / 269610	MGIID:	3036258	Length:	1955	Species:	Mus musculus

Alignment Length:	994	Identity:	514/994 - (51%)
Similarity:	660/994 - (66%)	Gaps:	136/994 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPD--------WKTP----------GKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCP 54
            ||:        |..|          .|...::..:...::::....|:|:||.|||:|||||:||
Mouse   373 DPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACP 437

  Fly    55 SVYHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWALDRS----------VE-----L 102
            |.||..||:|||..||.|:|:||||.  ||.||.::||.|||....:          ||     .
Mouse   438 SSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPP 502

  Fly   103 RTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEEL--DDQDG-- 163
            |..:|...||:|:||.|:|||||.|:.|.|:.|:|..|..::||::||:||...:.  .|:||
Mouse   503 RPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKS 567

  Fly   164 -----------NLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDS 217
                       .:.||||||||||||::|.|::|||.:..|...||:||::|.|:..:||.:...
Mouse   568 EKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEID 632

  Fly   218 IP---GLNQAIALYKKL----------RSSNKGR-----QRDRP--APTIDLNKKYEDQPVFLKE 262
            ||   .|.||...:::|          |...||:     ::::|  .|.:|...|::.||.::..
Mouse   633 IPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDA 697

  Fly   263 AGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLST 327
            .|..|||:|:||::|||:||.||..||||||||||||:||:||||||:||||.:||:|:|.||||
Mouse   698 TGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLST 762

  Fly   328 LTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVT----TKTMR-ENQTQYKFNVMLTS 387
            :.|||||.|:|||:.|.|||.|.|.:|:|||::|.|||:..    .|..| :.:.|.||:|:|||
Mouse   763 IINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTS 827

  Fly   388 YEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLL 452
            ||.|::|.|.||.|:||.|||||||||::|||||||:|:.|:|.|||||||||||||||||||||
Mouse   828 YELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLL 892

  Fly   453 NFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSM 517
            |||:..:||:|:.|..||.|:|||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.|
Mouse   893 NFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQM 957

  Fly   518 QKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLT 582
            |||:||.|||:||:|||.||||...|||||||||:||||||||||.||.||.:.|:|.|:.|||.
Mouse   958 QKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLV 1022

  Fly   583 KASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDR 647
            |:||||.||.||||:|:.:.||||:||||||||::||.|||.|||:|:||||.|.|.|||:||||
Mouse  1023 KSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDR 1087

  Fly   648 FNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVT 712
            ||.|.::.|.||||||||||||||||||||||:|||||||||:||||||||:||.||||||||||
Mouse  1088 FNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVT 1152

  Fly   713 HNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDG----------- 766
            ..||||||.||||.||||||||||||:|..:.:.:|.||:|||:||||:||||.
Mouse  1153 RASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRP 1217

  Fly   767 -----------------------------------KSEAIHYDDKAVADLLDRTNRGIEEKE-SW 795
                                               .|..|||||.|::.||||.....::.| ..
Mouse  1218 TTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQN 1282

  Fly   796 ANEYLSSFKVASYATKED---HEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVD 857
            .||||||||||.|..:|:   .|...:.....||.||.|||.|:           :...:|.|.|
Mouse  1283 MNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLL-----------RHHYEQQQED 1336

  Fly   858 VESIMGKGKRIRKEIDYSN 876
            :...:||||||||:::|::
Mouse  1337 LARNLGKGKRIRKQVNYND 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	28/76 (37%)
		CHROMO	181..233	CDD:214605	20/64 (31%)
		SNF2_N	270..561	CDD:278600	199/295 (67%)
		DEXDc	288..440	CDD:238005	100/156 (64%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
Chd5	XP_006538992.1	CHDNT	148..203	CDD:369683
		PHD1_CHD_II	347..389	CDD:277006	4/15 (27%)
		PHD2_CHD_II	420..462	CDD:277007	27/41 (66%)
		CD1_tandem_CHD3-4_like	467..546	CDD:349314	29/78 (37%)
		CD2_tandem_CHD3-4_like	591..644	CDD:349309	22/52 (42%)
		PLN03142	700..>1218	CDD:215601	353/517 (68%)
		DUF1087	1300..1359	CDD:368924	21/67 (31%)
		DUF1086	1393..1534	CDD:368921
		PRK13108	<1535..1687	CDD:237284
		CHDCT2	1733..1904	CDD:369684
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4514
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.770