DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and mit1

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_595385.1	Gene:	mit1 / 2541336	PomBaseID:	SPBP35G2.10	Length:	1418	Species:	Schizosaccharomyces pombe

Alignment Length:	1052	Identity:	325/1052 - (30%)
Similarity:	468/1052 - (44%)	Gaps:	279/1052 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KFRDEEYCKVC------SDGGDLLCCDSCPSVYHRTCLSPPLKSIPK--------GDWICPRCI- 80
            ||.....|..|      |.|.:.:.||.|.:|||..|  .||.|:.|        ..:|||.|.
pombe   208 KFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVYHYDC--SPLPSLNKETRNYSQQNGFICPLCSK 270

  Fly    81 --------------------------------------------------------------PL- 82
                                                                          ||
pombe   271 NSKDVLCNTGFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIRFRCFRCRRVEYFFYLDSNPLS 335

  Fly    83 --------------------PGKAEKILSWRW---------ALDRSVELRTSKGEKRREYFIKWH 118
                                |...|:|::||.         .|..:....:......||||::..
pombe   336 IQRTITHFIKKLVCNECSMHPCDIEEIIAWRTLNSLYPSKATLSNNFVSTSDLSFWSREYFVRSK 400

  Fly   119 GMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKP----EWL 179
            |.||.||.|.        .||.:|..         ||.:..:.|| |....|. ..||    .:.
pombe   401 GKSYLHCFWC--------SASWLAGI---------SLAKKKNFDG-LENASYD-ATKPIIPVSYT 446

  Fly   180 LVQRV--INHSEEPNGG-----------------TMYLVKWRELSYNDSSWE---RESD------ 216
            ::.:|  :.:....|..                 |...|.||.|:|..|:||   :|:|
pombe   447 IIDKVWDVQYRSGKNARTAKYKTKKHQLKAISEVTFAFVSWRGLTYYMSNWEPPPKETDRNRWKA 511

  Fly   217 ---SIPGLNQAIALYKKLRSSNKGRQRDRPAPT----IDL---NKKYEDQPVFLKEAGLKLHPFQ 271
               ....|.:.:.:.|              |||    |||   |.::..||.|:|  |..|.|:|
pombe   512 WLKGYSDLLECLWIEK--------------APTASINIDLPFTNLEWHSQPSFIK--GGTLMPYQ 560

  Fly   272 IEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELE 336
            ::|::||...|....|.|||||||||||:|.:.|:..||....| .|.|:.||.:|:.||||||:
pombe   561 LKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYRHKC-FPVLVIVPHATVANWERELK 624

  Fly   337 LWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCI 401
            .|||.|.....||.:..|:::|.:.:    :..|..:...|    :|::.|...:..:.:.|...
pombe   625 KWAPFLQINVLVGSEKNRSLVRDYRL----INQKDPKHVST----HVLVISASNVEREISLLRKF 681

  Fly   402 DWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTF 466
            .|..|:|||..||:::||..|..||..:..:||||||||||||:.|||:||.||:..|.|
pombe   682 QWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKIN----- 741

  Fly   467 QAEFT---DVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTK 528
            .||..   .:...|:|..||:||:|..|||:|::||.:.|.|.|.|:.:.::.:||..||.||:|
pombe   742 AAELEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSK 806

  Fly   529 NFKAL---------NQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYE--MSSLT 582
            |...|         :..||.|..||.||:|.|||...|||::....|:..:.    ||  |.||.
pombe   807 NLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHPYIYSPDIEDRNLP----YELAMRSLE 867

  Fly   583 KASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDR 647
            :||.|..:|..::.:|....||:|||||..:.|::||.:.|.:...|.|.||:.....||.|||.
pombe   868 EASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDS 932

  Fly   648 FNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVT 712
            ||.|.||...|||||||||:|||||:||||||.|.|:|||.|:||.:||||.||||||:::...|
pombe   933 FNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTT 997

  Fly   713 HNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNF-SKDELEDILRFGTEDLFKD-GKSEAIHYDD 775
            .:||||:|:|.|:.|::|.||:|.    .:..|. |:.:||.|||.|...||:: |...:|.|::
pombe   998 RDSVEEKIIQNAQKKLVLDHLIVE----SLDQNHNSEKDLESILRHGARALFEEAGDEPSIKYNE 1058

  Fly   776 KAVADLLDRTNRGIEEKES----------------WANEYLSSFKVASYATKED--HEEHDDYNN 822
            .:|..|:....:  :|..|                |.|:::||   ..|..||:  .:|.|
pombe  1059 YSVELLISEAEK--QEDTSTDESDIKSNKFGFFRVWDNKHISS---NHYEVKENVLVDEED---- 1114

  Fly   823 DAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDY-----------SN 876
                    .|..::        |:::|.:...:.| |:...:..|...:|.|           ..
pombe  1115 --------VWSVIL--------KQREKDAMLEKTD-ETTSNRRLRAHHKIHYGEDLNIYDNSDDT 1162

  Fly   877 QYPSPNRATPSS 888
            .|...:|::|.|
pombe  1163 DYTVNDRSSPGS 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	18/55 (33%)
		CHROMO	85..147	CDD:237991	18/70 (26%)
		CHROMO	181..233	CDD:214605	15/82 (18%)
		SNF2_N	270..561	CDD:278600	121/302 (40%)
		DEXDc	288..440	CDD:238005	58/151 (38%)
		Helicase_C	585..700	CDD:278689	61/114 (54%)
mit1	NP_595385.1	PHD	214..268	CDD:214584	18/55 (33%)
		SNF2_N	559..847	CDD:278600	120/301 (40%)
		DEXDc	577..720	CDD:238005	58/151 (38%)
		Helicase_C	870..985	CDD:278689	61/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910