Protein Alignment Chd3 and mit1

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_595385.1
• Gene: mit1 / 2541336
• PomBaseID: SPBP35G2.10
• Length: 1418
• Species: Schizosaccharomyces pombe
• Alignment Length: 1052
• Identity: 325/1052 - (30%)
• Similarity: 468/1052 - (44%)
• Gaps: 279/1052 - (26%)

  Fly    31 KFRDEEYCKVC------SDGGDLLCCDSCPSVYHRTCLSPPLKSIPK--------GDWICPRCI- 80
            ||.....|..|      |.|.:.:.||.|.:|||..|  .||.|:.|        ..:|||.|.
pombe   208 KFLHVCVCVKCHGREHRSSGKNFVYCDHCSNVYHYDC--SPLPSLNKETRNYSQQNGFICPLCSK 270

  Fly    81 --------------------------------------------------------------PL- 82
                                                                          ||
pombe   271 NSKDVLCNTGFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIRFRCFRCRRVEYFFYLDSNPLS 335

  Fly    83 --------------------PGKAEKILSWRW---------ALDRSVELRTSKGEKRREYFIKWH 118
                                |...|:|::||.         .|..:....:......||||::..
pombe   336 IQRTITHFIKKLVCNECSMHPCDIEEIIAWRTLNSLYPSKATLSNNFVSTSDLSFWSREYFVRSK 400

  Fly   119 GMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKP----EWL 179
            |.||.||.|.        .||.:|..         ||.:..:.|| |....|. ..||    .:.
pombe   401 GKSYLHCFWC--------SASWLAGI---------SLAKKKNFDG-LENASYD-ATKPIIPVSYT 446

  Fly   180 LVQRV--INHSEEPNGG-----------------TMYLVKWRELSYNDSSWE---RESD------ 216
            ::.:|  :.:....|..                 |...|.||.|:|..|:||   :|:|
pombe   447 IIDKVWDVQYRSGKNARTAKYKTKKHQLKAISEVTFAFVSWRGLTYYMSNWEPPPKETDRNRWKA 511

  Fly   217 ---SIPGLNQAIALYKKLRSSNKGRQRDRPAPT----IDL---NKKYEDQPVFLKEAGLKLHPFQ 271
               ....|.:.:.:.|              |||    |||   |.::..||.|:|  |..|.|:|
pombe   512 WLKGYSDLLECLWIEK--------------APTASINIDLPFTNLEWHSQPSFIK--GGTLMPYQ 560

  Fly   272 IEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELE 336
            ::|::||...|....|.|||||||||||:|.:.|:..||....| .|.|:.||.:|:.||||||:
pombe   561 LKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYRHKC-FPVLVIVPHATVANWERELK 624

  Fly   337 LWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCI 401
            .|||.|.....||.:..|:::|.:.:    :..|..:...|    :|::.|...:..:.:.|...
pombe   625 KWAPFLQINVLVGSEKNRSLVRDYRL----INQKDPKHVST----HVLVISASNVEREISLLRKF 681

  Fly   402 DWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTF 466
            .|..|:|||..||:::||..|..||..:..:||||||||||||:.|||:||.||:..|.|
pombe   682 QWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKIN----- 741

  Fly   467 QAEFT---DVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTK 528
            .||..   .:...|:|..||:||:|..|||:|::||.:.|.|.|.|:.:.::.:||..||.||:|
pombe   742 AAELEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSK 806

  Fly   529 NFKAL---------NQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYE--MSSLT 582
            |...|         :..||.|..||.||:|.|||...|||::....|:..:.    ||  |.||.
pombe   807 NLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHPYIYSPDIEDRNLP----YELAMRSLE 867

  Fly   583 KASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDR 647
            :||.|..:|..::.:|....||:|||||..:.|::||.:.|.:...|.|.||:.....||.|||.
pombe   868 EASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDS 932

  Fly   648 FNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVT 712
            ||.|.||...|||||||||:|||||:||||||.|.|:|||.|:||.:||||.||||||:::...|
pombe   933 FNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTT 997

  Fly   713 HNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNF-SKDELEDILRFGTEDLFKD-GKSEAIHYDD 775
            .:||||:|:|.|:.|::|.||:|.    .:..|. |:.:||.|||.|...||:: |...:|.|::
pombe   998 RDSVEEKIIQNAQKKLVLDHLIVE----SLDQNHNSEKDLESILRHGARALFEEAGDEPSIKYNE 1058

  Fly   776 KAVADLLDRTNRGIEEKES----------------WANEYLSSFKVASYATKED--HEEHDDYNN 822
            .:|..|:....:  :|..|                |.|:::||   ..|..||:  .:|.|
pombe  1059 YSVELLISEAEK--QEDTSTDESDIKSNKFGFFRVWDNKHISS---NHYEVKENVLVDEED---- 1114

  Fly   823 DAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDY-----------SN 876
                    .|..::        |:::|.:...:.| |:...:..|...:|.|           ..
pombe  1115 --------VWSVIL--------KQREKDAMLEKTD-ETTSNRRLRAHHKIHYGEDLNIYDNSDDT 1162

  Fly   877 QYPSPNRATPSS 888
            .|...:|::|.|
pombe  1163 DYTVNDRSSPGS 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	18/55 (33%)
		CD_CSD	82..146	CDD:475127	20/93 (22%)
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	15/88 (17%)
		PLN03142	266..>768	CDD:215601	221/517 (43%)
mit1	NP_595385.1	PHD	214..268	CDD:214584	18/55 (33%)
		CD_CSD	359..426	CDD:475127	20/83 (24%)
		PLN03142	546..>1086	CDD:215601	232/565 (41%)
		zf-CCCH_7	1235..1329	CDD:376012
		zf-CCCH_6	1331..1383	CDD:436598