DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd2

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001074814.2	Gene:	Chd2 / 244059	MGIID:	2448567	Length:	1827	Species:	Mus musculus

Alignment Length:	874	Identity:	346/874 - (39%)
Similarity:	492/874 - (56%)	Gaps:	122/874 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEG---QMLLHHASMVASFQRRSDMEEPSLEEL 158
            |.|.:..|.:.|...:|.|||.|.||.|..|..|.   |..:.....:.:|:::.|..:..|.::
Mouse   291 DPSDDFDTEREEGEVQYLIKWKGWSYIHSTWESEDSLQQQKVKGLKKLENFKKKEDEVKQWLGKV 355

  Fly   159 DDQDGNLH--ERFYRYGIKPEWLLVQRVI---------------NHSEE--PNGGTMYLVKWREL 204
            ..:|....  ::.....:..::.:|:|||               .||.:  |:....||.||..|
Mouse   356 SPEDVEYFSCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGL 420

  Fly   205 SYNDSSWERES----------DSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVF 259
            .|::.|||.|:          ||....|.:..:  ..|.....:||.|   .:.|.|    ||.:
Mouse   421 PYSECSWEDEALIGKKFQNCIDSFHSRNNSKTI--PTRECKALKQRPR---FVALKK----QPAY 476

  Fly   260 LKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVP 324
            |....|:|..:|:||::||.:||.:....||||||||||||||:.||..||.:....|||||.||
Mouse   477 LGGESLELRDYQLEGLNWLAHSWCKSNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVP 541

  Fly   325 LSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYE 389
            |||||:|:||.|:||||:..|.|:|...:|..||:    :|.:.::|.|     .|||.::|:||
Mouse   542 LSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIRE----YEWIHSQTKR-----LKFNALITTYE 597

  Fly   390 FISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNF 454
            .:..|...||.|:||.|.|||||||:::.|..::.|..::..::||:|||||||:|:||:.||:|
Mouse   598 ILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF 662

  Fly   455 LSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQK 519
            :...||...:.|: |.....:|...:.||::|||.:|||:|.||.||:|.|.|.|:|||:|::||
Mouse   663 IMPEKFEFWEDFE-EDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQK 726

  Fly   520 KFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKA 584
            ::||.|||:|:|||.:...|.....|||:|:|:|||||.||.  .|.|.:...||...:.||.::
Mouse   727 QYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLI--KAPEDSERESGQEVLQSLIRS 789

  Fly   585 SGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFN 649
            ||||.||.|:|.:|:...:|||:||||.:||::|..:|..:.|.:.|:||||||::|::|:|.||
Mouse   790 SGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFN 854

  Fly   650 DPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHN 714
            ...||.|.|||||||||||||||:||||:||||||||.||:||.:||||:||||:|.|||.||..
Mouse   855 ADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKG 919

  Fly   715 SVEERIMQVAKHKMMLTHLVVR-----------PGMGGMTTN-FSKDELEDILRFGTEDLFKDGK 767
            :|||.|::.||.||:|.|||::           ...|...:| |:|:||..||:||.|||||:.:
Mouse   920 TVEEEIIERAKKKMVLDHLVIQRMDTTGRTVLENNSGRSNSNPFNKEELTAILKFGAEDLFKEIE 984

  Fly   768 SEAIHYDDKAVADLL----DRTNRGIEEKESWANEYLSSFKVASYATKEDHEE-----HDDYNND 823
            .|.....:..:.::|    .|.|   |...|..:|.||.||||::||.||.||     |.|
Mouse   985 GEESEPQEMDIDEILRLAETREN---EVSTSATDELLSQFKVANFATMEDEEELEERPHKD---- 1042

  Fly   824 AENTDPFYWENLMGKSQPK----------------LPK----KQKKQSQQSQVDVESIMGKGKR- 867
                    |:.::.:.|.|                ||:    .:|.|:..|..|.||     ||
Mouse  1043 --------WDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTES-----KRQ 1094

  Fly   868 ------IRKEIDYSNQYPSP-NRATPSSI 889
                  ...|.|.|:....| .|..|.|:
Mouse  1095 AQRSSASESETDDSDDDKKPKRRGRPRSV 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991	16/52 (31%)
		CHROMO	181..233	CDD:214605	20/78 (26%)
		SNF2_N	270..561	CDD:278600	140/290 (48%)
		DEXDc	288..440	CDD:238005	73/151 (48%)
		Helicase_C	585..700	CDD:278689	71/114 (62%)
Chd2	NP_001074814.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..264
		CHROMO	282..344	CDD:237991	16/52 (31%)
		Chromo	379..447	CDD:278797	19/67 (28%)
		SNF2_N	487..768	CDD:278600	140/290 (48%)
		DEXDc	503..648	CDD:238005	73/153 (48%)
		DEAH box	617..620		2/2 (100%)
		Helicase_C	790..905	CDD:278689	71/114 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1124		26/111 (23%)
		DUF5102	<1042..1165	CDD:293709	21/99 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1329..1465
		DUF4208	1471..1553	CDD:290618
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1638
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1679..1827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910