DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd3

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_017169944.1	Gene:	Chd3 / 216848	MGIID:	1344395	Length:	2111	Species:	Mus musculus

Alignment Length:	952	Identity:	508/952 - (53%)
Similarity:	648/952 - (68%)	Gaps:	93/952 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RGADPDWKTPGKASKDKRPKTNAKKQKFRDE-------------EYCKVCSDGGDLLCCDSCPSV 56
            |..:..|..|....:..:.:...:::::.:|             |||:||.|||:|||||:|.|.
Mouse   465 RAPEGKWSCPHCEKEGVQWEAKEEEEEYEEEGEEGEKEEEDDHMEYCRVCKDGGELLCCDACISS 529

  Fly    57 YHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWA-----------LDRSVEL---RTS 105
            ||..||:|||..||.|:|:||||.  .|.|:.:|||.|||.           .|.:.::   |..
Mouse   530 YHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQADGNPDVPPPRPL 594

  Fly   106 KGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELD----DQDG--- 163
            :|...||:|:||.|:|||||.|..|.|:.:.|..|..::||::||:||  ..||    :.||
Mouse   595 QGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEP--PPLDYGSGEDDGKSD 657

  Fly   164 ----------NLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERESDSI 218
                      .:.|::||:||||||:.|.|:||||.:..|...|||||::|.|:.|:||.:..:|
Mouse   658 KRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSMDKKGNYHYLVKWKDLPYDQSTWEEDEMNI 722

  Fly   219 PGLNQAIALY---------------KKLRSSNKGRQRDRP--APTIDLNKKYEDQPVFLKEAGLK 266
            |..:.....|               :|.:...|..|.|.|  :||.|...|||.||.|:...|..
Mouse   723 PEYDDHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGT 787

  Fly   267 LHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNW 331
            ||.:|:||::|||:||.||..|||||||||||||||:||||||:||||.:||||:|.||||:.||
Mouse   788 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINW 852

  Fly   332 ERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMR-----ENQTQYKFNVMLTSYEFI 391
            |||.::|||:.|.|||.|.|.:||:||::|.|||:...|..:     :.:.|.||:|:|||||.|
Mouse   853 EREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELI 917

  Fly   392 SVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLS 456
            ::|.|.||.|.||.|||||||||::|||||||:|:.|:|.:|||||||||||||||||||||||:
Mouse   918 TIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLT 982

  Fly   457 SGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKF 521
            ..:||:|:.|..||.|:|||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.||||:
Mouse   983 PERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKY 1047

  Fly   522 YKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASG 586
            ||:|||:||:|||.:|||...|||||||||:||||||||||.||.|:...|||.||..:|.|:||
Mouse  1048 YKYILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSG 1112

  Fly   587 KLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDP 651
            ||.||.|||::||...||||:||||||||::||.||:.|||:|:||||.|.|.|||:||||||.|
Mouse  1113 KLLLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAP 1177

  Fly   652 VSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSV 716
            .::.|.||||||||||||||||||||||||||||||||:||||||||:||..|||||||||..||
Mouse  1178 GAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASV 1242

  Fly   717 EERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGK--------SEAIHY 773
            ||||.||||.||||||||||||:|....:.||.||:|||:||||:||||..        |..|||
Mouse  1243 EERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHY 1307

  Fly   774 DDKAVADLLDRTNRGIEEKE-SWANEYLSSFKVASYATKED---HEEHDDYNNDAENTDPFYWEN 834
            |::|:|.||||.....|:.: ...||||||||||.|..:|:   .|...:.....||.||.|||.
Mouse  1308 DNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEK 1372

  Fly   835 LMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSN 876
            |:           :...:|.|.|:...:|||||:||:::|::
Mouse  1373 LL-----------RHHYEQQQEDLARNLGKGKRVRKQVNYND 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	26/75 (35%)
		CHROMO	181..233	CDD:214605	21/66 (32%)
		SNF2_N	270..561	CDD:278600	197/295 (67%)
		DEXDc	288..440	CDD:238005	99/156 (63%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
Chd3	XP_017169944.1	CHDNT	200..253	CDD:369683
		PHD1_CHD_II	434..476	CDD:277006	3/10 (30%)
		PHD2_CHD_II	510..552	CDD:277007	24/43 (56%)
		CD1_tandem_CHD3-4_like	557..635	CDD:349314	33/97 (34%)
		CD2_tandem_CHD3-4_like	680..734	CDD:349309	19/70 (27%)
		PLN03142	771..>1325	CDD:215601	353/570 (62%)
		DEXHc_CHD3	788..1019	CDD:350813	151/235 (64%)
		DUF1087	<1364..1407	CDD:368924
		DUF1086	1430..1569	CDD:368921
		PHA03169	1589..>1759	CDD:223003
		CHDCT2	1790..>1917	CDD:369684
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4514
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780