Protein Alignment Chd3 and ssl-1

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001255179.1
• Gene: ssl-1 / 190954
• WormBaseID: WBGene00007027
• Length: 2395
• Species: Caenorhabditis elegans
• Alignment Length: 1129
• Identity: 263/1129 - (23%)
• Similarity: 397/1129 - (35%)
• Gaps: 450/1129 - (39%)

  Fly   147 RSDMEEPSLEELD--------DQDGNLHERFYRYGIKPEWL----LVQRVINHSEEPNGGTMYLV 199
            :|..:|...:|:|        |.|.      :.|.:.||:|    |.|..:   ||.....:...
 Worm   394 KSQKKEDVRQEVDALQNEATVDMDD------FLYTLPPEYLKAYGLTQEDL---EEMKREKLEEQ 449

  Fly   200 KWRELSYNDSSWERESDSIP--------------------------------GLNQAIALYKKLR 232
            |.|:.:..|:..:.|.|..|                                |:.:.:. |.||.
 Worm   450 KARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDGNGDGHGVLENVD-YVKLN 513

  Fly   233 SSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLK----------LHPFQIEGVSWLRYSWGQGIP 287
            |.:...::...|...:...|::.:...|:...:|          |..:|:.|:.|:...:.:.:.
 Worm   514 SQDSDERQQELANIAEEALKFQPKGYTLETTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLN 578

  Fly   288 TILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKT 352
            .||||||||||||||:..|..:.......||.||.||.|.:.|||.|.:.|.|.|..:||.|...
 Worm   579 GILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAK 643

  Fly   353 ARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSN 417
            .||..||          ..|:.|    .|:|.:|||:.::.|........|..|::|||..:::.
 Worm   644 ERAEKRK----------GWMKPN----CFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNW 694

  Fly   418 QSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTD---------- 472
            :|:.::.|...|...:||||||||||:|.||:.|::||....|:....|:..|::
 Worm   695 KSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNM 759

  Fly   473 VSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKG 537
            ......:.|||::|.|.:|||||.:|.|.:|.|:|.||...||..|:..|...:::.....|.|
 Worm   760 EFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENLK- 823

  Fly   538 GGRVCSLLNIMMDLRKCCNHPYLF-----------------------------PSAA-------- 565
            .|.:.|:|||:|.||||||||.||                             ||::
 Worm   824 SGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQLDVPARLFEISQQDPSSSSASQIPEI 888

  Fly   566 ----------------------------------------------------------------- 565
                                                                             
 Worm   889 FNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVGGFRFNRTAFVAKNPHTEESEDEGVMRSR 953

  Fly   566 ----------------------------------------------------------------- 565
                                                                             
 Worm   954 VLPKPINGTAQPLQNGNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNMANVGRGVVR 1018

  Fly   566 --EEATISPS------------------------------------------------------- 573
              :.|.:||.
 Worm  1019 LDDSARMSPPLKRQKLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVAL 1083

  Fly   574 -----------------------------------GLYEMSSLTKA------------------- 584
                                               |:|....||.|
 Worm  1084 VREEIIAEFPRLAVEEDEVVQERLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLS 1148

  Fly   585 --------------------------------------SGKLDLLSKMLKQLKADNHRVLLFSQM 611
                                                  .|||..|:.:|:||....||.|:|:||
 Worm  1149 NIELNSRSLLLNTSTNFDTRMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQM 1213

  Fly   612 TKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFN-DPVSEHFVFLLSTRAGGLGINLATAD 675
            :|||:||:.||...||||.|:||:...:.||..::||| ||  :.|.|:||||:||:|:||..||
 Worm  1214 SKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADP--KVFCFILSTRSGGVGVNLTGAD 1276

  Fly   676 TVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMG 740
            |||.:||||||..|.||..|.||:||.:.|.|||.::..::||.|::.|..|..|..|.:  ...
 Worm  1277 TVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAI--DEA 1339

  Fly   741 GMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWA-------NE 798
            |.|..|.|.  .|.:|    ||| ||::..:    .||||:...    :.|||...       ..
 Worm  1340 GFTPEFFKQ--SDSIR----DLF-DGENVEV----TAVADVATT----MSEKEMEVAMAKCEDEA 1389

  Fly   799 YLSSFKVASYATKEDHEEHDDYN-------NDAENTDPFYWENLMGKSQP-------KLPKKQKK 849
            .:::.|:|......|:.|.|:.:       ...|..|..|.| |:.:.:|       .|..:.|.
 Worm  1390 DVNAAKIAVAEANVDNAEFDEKSLPPMSNLQGDEEADEKYME-LIQQLKPIERYAINFLETQYKP 1453

  Fly   850 QSQQSQVDVESIMGKGKRIRKEID 873
            :.::...:.|:::.:.   |:|.|
 Worm  1454 EFEEECKEAEALIDQK---REEWD 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	15/89 (17%)
		PLN03142	266..>768	CDD:215601	211/838 (25%)
ssl-1	NP_001255179.1	HSA	231..295	CDD:462194
		PLN03142	372..>851	CDD:215601	143/481 (30%)
		DEXQc_SRCAP	558..780	CDD:350761	81/235 (34%)
		SF2_C_SNF	1183..1312	CDD:350180	68/130 (52%)
		Med15	1978..>2359	CDD:312941