DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and let-418

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_504523.1	Gene:	let-418 / 178970	WormBaseID:	WBGene00002637	Length:	1829	Species:	Caenorhabditis elegans

Alignment Length:	944	Identity:	470/944 - (49%)
Similarity:	618/944 - (65%)	Gaps:	102/944 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PKTNAKKQKFRDEEYCKVCSDGGDLLCCDSCPSVYHRTCLSPPLKSIPKGD-WICPRC--IPLPG 84
            |:...::...:::|:||:|.:..:||.||||...:|..|:.|||..:||.: |.||||  :....
Worm   305 PEVVKEEPAKQNDEFCKICKETENLLLCDSCVCSFHAYCIDPPLTEVPKEETWSCPRCETVKPEH 369

  Fly    85 KAEKILSWRW-------ALDRSVEL----------RTSKGEKRREYFIKWHGMSYWHCEWIPEGQ 132
            |.||||.|||       .|:...|.          |..:..:.||:|:||..:|||.|.|:.|..
Worm   370 KIEKILCWRWKEIPYPEPLEAGKEASSDDAMLKPPRKMEPRREREFFVKWKYLSYWQCSWVSEML 434

  Fly   133 MLLHHASMVASFQRRSDMEEP--------SLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSE 189
            :.:|...::..:.|::|.:.|        |....|:....|.||||:|||||||:.:.|:|||..
Worm   435 LEVHFRMLILLYWRKNDSDAPPEFEESVTSRHHSDNDPYKLRERFYQYGIKPEWMQIHRIINHQS 499

  Fly   190 EPNGGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKLRSSN------------------- 235
            .......|||||:||||:.::|||:..:|....:||..|.:.|.|.
Worm   500 YAKSQQDYLVKWKELSYDQATWERDDSNIANYEEAIIKYWQHRESKLNEDIPKNVQKMIAKHREA 564

  Fly   236 KG------RQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEM 294
            ||      .::.:....||:.||||.||.::.|.|.||||:|:||::|||:.|..|...||||||
Worm   565 KGLPPKEDEKKKKKREKIDIRKKYEVQPDYVTETGGKLHPYQLEGLNWLRHCWSNGTDAILADEM 629

  Fly   295 GLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRK 359
            |||||:|::.|||||.|||||:|||||:.||||:.|||||.|.|.|:.|.|||||.:.||.|:|:
Worm   630 GLGKTVQSLTFLYSLMKEGHCKGPFLIAAPLSTIINWEREAEQWCPDFYVVTYVGLRDARVVLRE 694

  Fly   360 HEISFEEVTTKT------MRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQ 418
            ||.||.|...::      |:..:.. ||:|:|||||.|::|...|..|:|.||||||||||::||
Worm   695 HEFSFVEGAVRSGPKASKMKTTENM-KFHVLLTSYETINMDKTILSSIEWGALVVDEAHRLKNNQ 758

  Fly   419 SKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLH 483
            |.||:.|::|.|.|::||||||||||||||||||||||..:||.|:.|.|||.::|||:|:::||
Worm   759 SLFFKNLNEYTIHYRVLLTGTPLQNNLEELFHLLNFLSKERFNQLEAFTAEFNEISKEDQIEKLH 823

  Fly   484 EILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIM 548
            .:|.||||||||||||..||.|||.|||||||:||||:||:|||:||.|||.|.||...||:|::
Worm   824 NLLGPHMLRRLKADVLTGMPSKSELIVRVELSAMQKKWYKNILTRNFDALNVKNGGTQMSLMNVL 888

  Fly   549 MDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTK 613
            |:|:|||||||||..|..||....:|:||.::|.|.|||..||.|||::||...||||:|||||:
Worm   889 MELKKCCNHPYLFVKAELEAPKEKNGMYEGTALIKNSGKFVLLQKMLRKLKDGGHRVLIFSQMTR 953

  Fly   614 MLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVI 678
            ||:::|...|.|||:|:||||||.|.:||.||||:|.|.::.|:|||||||||||||||||||||
Worm   954 MLDIMEDLCEYEGYRYERIDGSIMGQMRQDAIDRYNAPGAQQFIFLLSTRAGGLGINLATADTVI 1018

  Fly   679 IFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMT 743
            |:|||||||||:||||||||:|||.|||||||||..||||:|..|||.||:|.|||||.|:||..
Worm  1019 IYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKKSVEEKITSVAKKKMLLNHLVVRAGLGGKE 1083

  Fly   744 -TNFSKDELEDILRFGTEDLF--------------KDGKSEAIHYDDKAVADLLDRTNR------ 787
             ...||.||:|:||:|||:||              |...::.|.:||.||..||||:|:
Worm  1084 GKTMSKTELDDVLRWGTEELFSEDLDAAEGEGSEKKGAAAQEIVWDDAAVDALLDRSNKEETPAG 1148

  Fly   788 --GIEEKESWANEYLSSFKVASYATK-------EDHEEHDDYNNDAENTDPFYWENLMGKSQPKL 843
              | |||..|.||||||||||||.||       |:.||.:....|.:..||.|||.|:
Worm  1149 EDG-EEKAEWQNEYLSSFKVASYQTKETEGQEEEEEEETEVIKEDEKEPDPDYWEKLL------- 1205

  Fly   844 PKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSNQ 877
               :....|..:::::. :|||||:||:|:|:::
Worm  1206 ---KHHYEQDREIELQK-LGKGKRVRKQINYASE 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	19/42 (45%)
		CHROMO	85..147	CDD:237991	23/78 (29%)
		CHROMO	181..233	CDD:214605	20/51 (39%)
		SNF2_N	270..561	CDD:278600	184/296 (62%)
		DEXDc	288..440	CDD:238005	91/157 (58%)
		Helicase_C	585..700	CDD:278689	82/114 (72%)
let-418	NP_504523.1	CHDNT	95..147	CDD:285335
		TNG2	<151..300	CDD:227367
		PHD1_CHD_II	258..300	CDD:277006
		RanBP2-type Zn finger	295..323	CDD:275375	4/17 (24%)
		PHD_SF	320..362	CDD:304600	19/41 (46%)
		CHROMO	367..449	CDD:237991	23/81 (28%)
		CHROMO	489..543	CDD:214605	20/53 (38%)
		SNF2_N	605..901	CDD:278600	184/296 (62%)
		DEXDc	622..780	CDD:238005	91/158 (58%)
		Helicase_C	925..1040	CDD:278689	82/114 (72%)
		DUF1087	1188..1238	CDD:283996	17/59 (29%)
		DUF1086	1276..1406	CDD:283992
		CHDCT2	1524..1698	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167448
Domainoid	1	1.000	408	1.000	Domainoid score	I354
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740