Protein Alignment Chd3 and isw-1

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: NP_001379931.1
• Gene: isw-1 / 175944
• WormBaseID: WBGene00002169
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 255/752 - (33%)
• Similarity: 394/752 - (52%)
• Gaps: 72/752 - (9%)

  Fly   148 SDMEEPSLEELDDQD-----GNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYN 207
            |...:||: |:||:.     .:..:||.|        |:|:..|.|...:.|...|.....:...
 Worm    24 SSGNDPSM-EVDDEPESSDAADSFKRFER--------LLQKTENFSHCLSSGDAKLATGAPVDTK 79

  Fly   208 DSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLK-----EAGLKL 267
            ......:.:.|.|.:       :.|.:.:....:..|..|    |.:|..:|.|     |.| ::
 Worm    80 KRGRPSKKNGIDGDH-------RHRKTEQEEDEEMVADAI----KSDDLVIFDKSPFYIENG-EM 132

  Fly   268 HPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWE 332
            ..:|:.|::||.......|..|||||||||||:||:..:..:....:...|.|:.||.|||.||.
 Worm   133 RDYQVRGLNWLASLQHNKINGILADEMGLGKTLQTISMIGYMKHYKNKASPHLVIVPKSTLQNWA 197

  Fly   333 RELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAF 397
            .|.:.|.|.:..|..:|.:.||              .:.:|:.....||:|..|:||.:......
 Worm   198 NEFKKWCPSINAVVLIGDEAAR--------------NQVLRDVILPQKFDVCCTTYEMMLKVKTQ 248

  Fly   398 LGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFND 462
            |..::|..:::|||||:::.:||....:.:.....:||:|||||||||.||:.|||||....|..
 Worm   249 LKKLNWRYIIIDEAHRIKNEKSKLSETVRELNSENRLLITGTPLQNNLHELWALLNFLLPDIFTS 313

  Fly   463 LQTFQAEFTD---VSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKH 524
            ...|.:.|::   ....:.|:|||::|:|.:|||:|:||.||:.||.|..|.|.||.||:::|..
 Worm   314 SDDFDSWFSNDAMSGNTDLVQRLHKVLQPFLLRRIKSDVEKSLLPKKEVKVYVGLSKMQREWYTK 378

  Fly   525 ILTKNFKALNQKGGGRV--CSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTKASGK 587
            :|.|:...:|  |.|:|  ..|:||:|.||||.||||||..|......:..     ..|...|||
 Worm   379 VLMKDIDIIN--GAGKVEKARLMNILMHLRKCVNHPYLFDGAEPGPPFTTD-----QHLVDNSGK 436

  Fly   588 LDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPV 652
            :.:|.|:|.:.|....|||:|||.::||::||.|.....|:|.|:|||...:.|..||:.:|.|.
 Worm   437 MVVLDKLLMKFKEQGSRVLIFSQFSRMLDLLEDFCWWRHYEYCRLDGSTPHEDRSNAIEAYNAPD 501

  Fly   653 SEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVE 717
            |:.|:|:|:||||||||||||||.|||:||||||.:|:||..||||:||||:|.::|.:|.|:|:
 Worm   502 SKKFIFMLTTRAGGLGINLATADVVIIYDSDWNPQSDLQAMDRAHRIGQKKQVRVFRLITENTVD 566

  Fly   718 ERIMQVAKHKMMLTHLVVRPG-MGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADL 781
            |||::.|:.|:.|.::|::.| |........|.::..::|.|.|.:|. .|...|..||  :..:
 Worm   567 ERIIEKAEAKLRLDNIVIQQGRMSEAQKTLGKGDMISMIRHGAEQVFA-AKDSTISDDD--IDTI 628

  Fly   782 LDRTNRGIEEKESWANEYLSSFKVASY--ATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLP 844
            |::.    |.|.:..||.:......:.  .|.||:.:...|..:.||......:. ||....:.|
 Worm   629 LEKA----EVKTAELNEKMGKIDENNLRNMTFEDNAKFTVYQFEGENYKAKQADG-MGHFWIEPP 688

  Fly   845 KKQKKQSQQSQVDVESIMGKGKRIRKEIDYSNQYPSP 881
            |:::|.:.|..:..:..|..|....|:    ::.|.|
 Worm   689 KRERKANYQVDLYYKEAMRAGNPTEKQ----SKAPRP 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	8/53 (15%)
		PLN03142	266..>768	CDD:215601	203/507 (40%)
isw-1	NP_001379931.1	PLN03142	48..1008	CDD:215601	249/727 (34%)