Protein Alignment Chd3 and Smarca4

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_063120900.1
• Gene: Smarca4 / 171379
• RGDID: 621728
• Length: 1650
• Species: Rattus norvegicus
• Alignment Length: 784
• Identity: 266/784 - (33%)
• Similarity: 408/784 - (52%)
• Gaps: 110/784 - (14%)

  Fly   147 RSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSW 211
            |||.||...||.::::    |.......:|..|.|:.. ....:|:...:..|..|.:..|.
  Rat   654 RSDSEESGSEEEEEEE----EEEQPQPAQPPTLPVEEK-KKIPDPDSDDVSEVDARHIIENA--- 710

  Fly   212 ERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVS 276
            :::.|...|::||:|         :|.| ...|....:.::.:.|...:....||  .:||:|:.
  Rat   711 KQDVDDEYGVSQALA---------RGLQ-SYYAVAHAVTERVDKQSALMVNGVLK--QYQIKGLE 763

  Fly   277 WLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPE 341
            ||...:...:..||||||||||||||:..:..|.:.....|||||.||||||:||..|.:.|||.
  Rat   764 WLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPS 828

  Fly   342 LYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAAL 406
            :..|:|.|...||...           ...:|..    ||||:||:||:|..|...|..|.|..:
  Rat   829 VVKVSYKGSPAARRAF-----------VPQLRSG----KFNVLLTTYEYIIKDKHILAKIRWKYM 878

  Fly   407 VVDEAHRLRSNQSKFFRILSKYRIG-YKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQ--- 467
            :|||.||::::..|..::|:.:.:. .:||||||||||.|.||:.|||||....|....||:
  Rat   879 IVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWF 943

  Fly   468 -------AEFTDVSKEEQ---VKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFY 522
                   .|..|:::||.   ::|||::|.|.:|||||.:|...:|.|.|::::.::|::|:..|
  Rat   944 NAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLY 1008

  Fly   523 KH-----ILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAE---EATISPSGLYEMS 579
            :|     :|..:....::||.|...:|:|.:|.|||.|||||:|....|   |......|:.:..
  Rat  1009 RHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGL 1073

  Fly   580 SLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKA 644
            .|.:||||.:||.::|.:|:|.||:||||.|||.::.::|.:....|::|.|:||:.|.:.|...
  Rat  1074 DLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGML 1138

  Fly   645 IDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYR 709
            :..||:|.||:|:|||||||||||:||.:||||||||||||||.|:||..||||:||:.:|.:.|
  Rat  1139 LKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLR 1203

  Fly   710 FVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDE--LEDILRFGTEDLFK-----DGK 767
            ..|.|||||:|:..||:|:.:...|::.||....::..:..  |:.||....:|..:     .|.
  Rat  1204 LCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGS 1268

  Fly   768 SEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATKEDHEEHDDYN------NDAEN 826
            :...|     .|......|..:||.                ..||:.|..||..      ...|.
  Rat  1269 ASFAH-----TAPPPAGVNPDLEEP----------------PLKEEDEVPDDETVNQMIARHEEE 1312

  Fly   827 TDPFYWENL-MGKSQPKLPKKQKKQSQQSQV------------------DVESIMGKGKRIRKEI 872
            .|.|...:| ..:.:.:.||::.:..::.::                  :.|.:.|:|.|.|||:
  Rat  1313 FDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEV 1377

  Fly   873 DYSN 876
            |||:
  Rat  1378 DYSD 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	12/53 (23%)
		PLN03142	266..>768	CDD:215601	215/530 (41%)
Smarca4	XP_063120900.1	None