Protein Alignment Chd3 and Hel89B

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_321235.5
• Gene: Hel89B / 1281292
• VectorBaseID: AGAMI1_004308
• Length: 2067
• Species: Anopheles gambiae
• Alignment Length: 582
• Identity: 170/582 - (29%)
• Similarity: 283/582 - (48%)
• Gaps: 98/582 - (16%)

  Fly   245 PTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSL 309
            |.::|       ||   :...:|..:|..||:||.:.....:..||.|:||||||:|.:..|.:
Mosquito  1450 PDVEL-------PV---KINAELRSYQQSGVNWLWFLNRYKLHGILCDDMGLGKTLQAICILAA- 1503

  Fly   310 FKEGHCRG--------PFLISVPLSTLTNWERELELWAPELYC--VTYVGGKTARAVIRKHEISF 364
              :.|.|.        |.::..|.:...:|..|:|.:.|..:.  :.|||....|..:|
Mosquito  1504 --DHHQRSLDRGCAQLPSIVICPPTLTGHWVYEVEKFLPSRFLRPLHYVGLPGNREQLR------ 1560

  Fly   365 EEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYR 429
                       |....:|:::.||:.:..|..|...::|...::||.|.:::.::|..:.:.:..
Mosquito  1561 -----------QKLGTYNLIVASYDIVRKDIEFFSSVNWNYCILDEGHIIKNGRTKSSKAIKQLV 1614

  Fly   430 IGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFT----------DVSKEEQ-----V 479
            ..::|:|:|||:|||:.||:.|.:||..|.....:.|...|:          ...||::     :
Mosquito  1615 ANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFSTRFSRPILASRDPKSSPKEQEAGALAM 1679

  Fly   480 KRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYK-----HILTKNFKALNQKGGG 539
            :.||..:.|.:|||:|.|||..:|||....:..|||.:|::.|:     |:.:.:.:...:...|
Mosquito  1680 EALHRQVLPFLLRRVKEDVLTDLPPKITQDLLCELSPLQERLYEDFSRMHLHSSDIRECLENIDG 1744

  Fly   540 RVCSLLN-------IMMDLRKCCNHP--YLFPSAAE------EATISPSGLYEMSSLTKASGKLD 589
            ::....|       .:..|:..||||  .|.||..|      |.|.:.|.:.::    :.|.||.
Mosquito  1745 QMAGPANKKTHVFQALRYLQNVCNHPKLVLSPSHPEYQMIVGEFTRNGSSMDDI----EHSAKLP 1805

  Fly   590 LLSKML--------KQLKADNHRVLLFSQMTKMLNVLEHFLEGE---GYQYDRIDGSIKGDLRQK 643
            :|.::|        :.:..:.||.|:|.|:..||:::|:.|..:   ...|.|:|||:....|..
Mosquito  1806 VLKQLLLDCGIGTNEDVSVNQHRALIFCQLKAMLDIVENDLLKKHLPAVSYLRLDGSVPPSTRHH 1870

  Fly   644 AIDRFN-DPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMI 707
            .:.:|| ||..:  |.||:|:.||||:||..|||||..:.||||..|:||..||||:||||.|.:
Mosquito  1871 IVTKFNGDPSID--VLLLTTQVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1933

  Fly   708 YRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSE 769
            ||.:|..|:||:||.:.|.|::..:.||......|.| ...|:|.|:.....:    .||.:
Mosquito  1934 YRLITRKSLEEKIMGLQKFKLLTANTVVSDENASMDT-MGTDQLLDLFTLADD----SGKQQ 1990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309
		PLN03142	266..>768	CDD:215601	165/558 (30%)
Hel89B	XP_321235.5	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		DUF3535	715..1242	CDD:463447
		HepA	<1453..1962	CDD:440319	161/544 (30%)