DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and Chd1

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_031716.2	Gene:	Chd1 / 12648	MGIID:	88393	Length:	1711	Species:	Mus musculus

Alignment Length:	958	Identity:	340/958 - (35%)
Similarity:	522/958 - (54%)	Gaps:	174/958 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSKRGADPDWKTPGKASKDKRPKTNAKKQ-----KFRDEEYCKVCSDGGDLLCCDSCPSVYHRTC 61
            ||:...|.|:      ..|||   ::::|     .::::|..|..||  |||
Mouse   214 SSEDEDDEDY------DNDKR---SSRRQATVNVSYKEDEEMKTDSD--DLL------------- 254

  Fly    62 LSPPLKSIPKGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKG------------------E 108
                        .:|...:|.| :.|:..:....:|..|..:.:.|                  |
Mouse   255 ------------EVCGEDVPQP-EDEEFETIERVMDCRVGRKGATGATTTIYAVEADGDPNAGFE 306

  Fly   109 KRRE-----YFIKWHGMSYWHCEWIPE---GQMLLHHASMVASFQRRSDMEEPSLEELDDQD--- 162
            :.:|     |.|||.|.|:.|..|..|   .|..:.....:.:::::....:..|:....:|
Mouse   307 RNKEPGDIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEY 371

  Fly   163 --------GNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTM--YLVKWRELSYNDSSWERESDS 217
                    .:||:::.         :|:|:|.||.:.:...:  |..||:.|.|::.|||
Mouse   372 YNCQQELTDDLHKQYQ---------IVERIIAHSNQKSAAGLPDYYCKWQGLPYSECSWE----- 422

  Fly   218 IPGLNQAIALYKKLRS---SNKGRQRDRPAPTIDLNKKYEDQPVF--LKE--------AGLKLHP 269
                 ....:.||.::   ....|.:.:..|..|. |..:.:|.|  ||:        .||:|..
Mouse   423 -----DGALISKKFQTCIDEYFSRNQSKTTPFKDC-KVLKQRPRFVALKKQPSYIGGHEGLELRD 481

  Fly   270 FQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERE 334
            :|:.|::||.:||.:|...||||||||||||||:.||..||.|....||||:.|||||||:|:||
Mouse   482 YQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQRE 546

  Fly   335 LELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLG 399
            ::.||.::..|.|:|...:|.:||.||         .|.....:.|||::||:||.:..|.||||
Mouse   547 IQTWASQMNAVVYLGDINSRNMIRTHE---------WMHPQTKRLKFNILLTTYEILLKDKAFLG 602

  Fly   400 CIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQ 464
            .::||.:.|||||||:::.|..::.|..::..::||:|||||||:|:||:.||:|:...||:..:
Mouse   603 GLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWE 667

  Fly   465 TFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKN 529
            .|:.|. ...:|.....||:.|||.:|||:|.||.||:|.|.|.|:|:|:|::||::||.|||:|
Mouse   668 DFEEEH-GKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRN 731

  Fly   530 FKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYE-------MSSLTKASGK 587
            :|||::...|.....|||||:|:|||||.||         |.|....|       :..|.::|||
Mouse   732 YKALSKGSKGSTSGFLNIMMELKKCCNHCYL---------IKPPDNNEFYNKQEALQHLIRSSGK 787

  Fly   588 LDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPV 652
            |.||.|:|.:|:...:|||:||||.:||::|..:|:...:.:.|:||||||:||::|:|.||...
Mouse   788 LILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEG 852

  Fly   653 SEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVE 717
            ||.|.|||||||||||||||:||||:||||||||.||:||.:||||:||||:|.|||.||..|||
Mouse   853 SEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVE 917

  Fly   718 ERIMQVAKHKMMLTHLVV-RPGMGGMT-----------TNFSKDELEDILRFGTEDLFKDGKSEA 770
            |.|::.||.||:|.|||: |....|.|           |.|:|:||..||:||.|:|||:.:.|.
Mouse   918 EDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEE 982

  Fly   771 IHYDDKAVADLLDRTNRGIEEKE----SWANEYLSSFKVASYATKEDHEEHDDYNNDAENTDPFY 831
            ....:..:.::|.|..  ..|.|    |..:|.||.||||:::..::.:...:...:::|
Mouse   983 QEPQEMDIDEILKRAE--THENEPGPLSVGDELLSQFKVANFSNMDEDDIELEPERNSKN----- 1040

  Fly   832 WENLMGKSQPKLPKKQKK--QSQQSQVDVESI--MGKGKRIRKEIDYS 875
            ||.:       :|::|::  :.::.|.::|.|  :.:.:...|:|.::
Mouse  1041 WEEI-------IPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQISFN 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	7/41 (17%)
		CHROMO	85..147	CDD:237991	16/87 (18%)
		CHROMO	181..233	CDD:214605	15/53 (28%)
		SNF2_N	270..561	CDD:278600	138/290 (48%)
		DEXDc	288..440	CDD:238005	71/151 (47%)
		Helicase_C	585..700	CDD:278689	71/114 (62%)
Chd1	NP_031716.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..250		10/44 (23%)
		CHROMO	304..353	CDD:237991	12/48 (25%)
		Chromo	388..441	CDD:278797	15/62 (24%)
		SNF2_N	482..763	CDD:278600	139/299 (46%)
		DEXDc	498..643	CDD:238005	71/153 (46%)
		DEAH box	612..615		2/2 (100%)
		HDA2-3	716..969	CDD:288366	134/261 (51%)
		Helicase_C	801..900	CDD:278689	62/98 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1119		1/4 (25%)
		PRK12279	<1276..1466	CDD:138835
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1322..1407
		DUF4208	1407..1498	CDD:290618
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1503..1588
		DUF1777	1581..>1697	CDD:285811
		PHA03420	1591..>1691	CDD:177648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1657
		3 X 5 AA repeats of H-S-D-H-R	1629..1645
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1670..1711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910