DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and CHD4

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001264.2	Gene:	CHD4 / 1108	HGNCID:	1919	Length:	1912	Species:	Homo sapiens

Alignment Length:	966	Identity:	512/966 - (53%)
Similarity:	659/966 - (68%)	Gaps:	113/966 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPD--------WKTP--------GKASKDKRPKTNAKKQKFRDE-------------EYCKVCSD 43
            |||        |..|        .:|.:|     |::.::..:|             |:|:||.|
Human   398 DPDMEKAPEGKWSCPHCEKEGIQWEAKED-----NSEGEEILEEVGGDLEEEDDHHMEFCRVCKD 457

  Fly    44 GGDLLCCDSCPSVYHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRW------------ 94
            ||:|||||:|||.||..||:|||..||.|:|:||||.  .|.||.:|||.|:|
Human   458 GGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRP 522

  Fly    95 --ALDRSVELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEP---- 153
              |...:...:..:|...|::|:||.|||||||.|:.|.|:.||...|..::||::||:||
Human   523 PDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGD 587

  Fly   154 ---------SLEELDDQDGNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDS 209
                     ..:..|.:...:.||||||||||||:::.|::|||.:..|...||:|||:|.|:.:
Human   588 FGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQA 652

  Fly   210 SWERESDSIPG---LNQAIALYKKLRSSNKG-----------RQRDRP--APTIDLNKKYEDQPV 258
            |||.|...|..   ..|:...:::|....:|           |:.:||  .||:|...|||.||.
Human   653 SWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPE 717

  Fly   259 FLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISV 323
            :|...|..|||:|:||::|||:||.||..||||||||||||:||.||||||:||||.:||||:|.
Human   718 YLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSA 782

  Fly   324 PLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTK-----TMRENQTQYKFNV 383
            ||||:.|||||.|:|||::|.|||||.|.:||:||::|.|||:...:     :..:.:...||:|
Human   783 PLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHV 847

  Fly   384 MLTSYEFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEEL 448
            :|||||.|::|.|.||.||||.|:|||||||::|||||||:|:.|.:.:||||||||||||||||
Human   848 LLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEEL 912

  Fly   449 FHLLNFLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVE 513
            |||||||:..:|::|:.|..||.|::||:|:|:||::|.|||||||||||.|:||.|:|.|||||
Human   913 FHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVE 977

  Fly   514 LSSMQKKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEM 578
            ||.||||:||:|||:||:|||.:|||...||||::|||:||||||||||.||.||...|:|:|:.
Human   978 LSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDG 1042

  Fly   579 SSLTKASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQK 643
            |:|.:|||||.||.||||.||...||||:||||||||::||.|||.|||:|:||||.|.|::||:
Human  1043 SALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQE 1107

  Fly   644 AIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIY 708
            ||||||.|.::.|.||||||||||||||||||||||:|||||||||:||||||||:||.||||||
Human  1108 AIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIY 1172

  Fly   709 RFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKD-------- 765
            ||||..||||||.||||.||||||||||||:|..|.:.||.||:|||:||||:||||
Human  1173 RFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGD 1237

  Fly   766 ---GK-SEAIHYDDKAVADLLDRTNRGIEEKE-SWANEYLSSFKVASYATKEDH--EEHD---DY 820
               |: |..|||||||:..||||.....|:.| ...||||||||||.|..:|:.  ||.:   :.
Human  1238 NKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREI 1302

  Fly   821 NNDAENTDPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSN 876
            ....|:.||.|||.|:           :...:|.|.|:...:||||||||:::|::
Human  1303 IKQEESVDPDYWEKLL-----------RHHYEQQQEDLARNLGKGKRIRKQVNYND 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	26/75 (35%)
		CHROMO	181..233	CDD:214605	19/54 (35%)
		SNF2_N	270..561	CDD:278600	191/295 (65%)
		DEXDc	288..440	CDD:238005	97/156 (62%)
		Helicase_C	585..700	CDD:278689	88/114 (77%)
CHD4	NP_001264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		CHDNT	164..216	CDD:285335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..360
		PHD1_CHD_II	372..414	CDD:277006	5/15 (33%)
		PHD2_CHD_II	451..493	CDD:277007	27/41 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..538		2/27 (7%)
		CHROMO	<540..577	CDD:237991	18/36 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..603		4/24 (17%)
		CHROMO	622..676	CDD:214605	18/53 (34%)
		SNF2_N	729..1025	CDD:278600	191/295 (65%)
		DEXDc	746..904	CDD:238005	97/157 (62%)
		DEAH box	873..876		2/2 (100%)
		Helicase_C	1068..1164	CDD:278689	75/95 (79%)
		DUF1087	1302..1352	CDD:283996	19/57 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1401		1/4 (25%)
		DUF1086	1385..1521	CDD:283992
		Neuromodulin	<1517..1649	CDD:284117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1525..1562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1589
		Required for interaction with PCNT. /evidence=ECO:0000269\|PubMed:17626165	1577..1912
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1594..1644
		CHDCT2	1726..1896	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4543
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101931
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780