DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chd3 and Btaf1

DIOPT Version :10

Sequence 1:NP_649111.1 Gene:Chd3 / 40111 FlyBaseID:FBgn0023395 Length:892 Species:Drosophila melanogaster
Sequence 2:NP_001074175.1 Gene:Btaf1 / 107182 MGIID:2147538 Length:1848 Species:Mus musculus


Alignment Length:861 Identity:227/861 - (26%)
Similarity:355/861 - (41%) Gaps:231/861 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 PSVYHRTCLSPPLKSIPKGDWICPRCIPLPGK----------AEKILSWRWALDRSVELRTSKGE 108
            |.:|  .||..|..::..   :..|||.:..|          .||:|.|..|:|.:|:       
Mouse  1108 PHLY--MCLQYPSTAVRH---MAARCIGVMSKIATMETMNIFLEKVLPWLGAIDDNVK------- 1160

  Fly   109 KRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYG 173
                                .||.:     ..:|..          :|:||            .|
Mouse  1161 --------------------QEGAI-----EALACV----------MEQLD------------VG 1178

  Fly   174 IKPE-WLLVQRVINHSEEPNGGTMY--------LVKWRELSYNDSSWERESDSIPGLNQAIALYK 229
            |.|. .|||..|:....:......:        |::...|       |......|.:::.:.   
Mouse  1179 IVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPL-------EAGIPDPPNMSEELI--- 1233

  Fly   230 KLRSSNKGRQRDRPAPTIDLNKKYEDQ--PVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILAD 292
                ..|.::|......:| .||.|:.  ||   ....:|..:|.:||:||.:.....:..||.|
Mouse  1234 ----QLKAKERHFLEQLLD-GKKLENYKIPV---PINAELRKYQQDGVNWLAFLNKYKLHGILCD 1290

  Fly   293 EMGLGKTIQTVVFL----------YSLFKEGHCRG-PFLISVPLSTLTNWERELELWAPELYC-- 344
            :||||||:|::..|          |:..|...|.. |.|:..|.:...:|..|:..:....|.  
Mouse  1291 DMGLGKTLQSICILAGDHCQRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSREYLNP 1355

  Fly   345 VTYVGGKTARAVIR-KHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVV 408
            :.|.|..|.|  || :|::.                :.|:::.||:.:..|..|...|.:...::
Mouse  1356 LHYTGPPTER--IRLQHQVK----------------RHNLIVASYDVVRNDIDFFRNIKFNYCIL 1402

  Fly   409 DEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEF--- 470
            ||.|.:::.::|..:.:.:....|:::|:|||:|||:.||:.|.:||..|.....:.|.|.:   
Mouse  1403 DEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKP 1467

  Fly   471 -------TDVSKEEQ-----VKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYK 523
                   ...|:|::     :..||..:.|.:|||:|.|||:.:|||........||.:|.:.|:
Mouse  1468 ILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYE 1532

  Fly   524 HILTKNFK----------ALNQ-------KGGGRVCSLLNIMMDLRKCCNHPYL--------FPS 563
            .......|          ||::       |..|.|...|..   |||.||||.|        |.|
Mouse  1533 DFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQY---LRKLCNHPALVLTPQHPEFKS 1594

  Fly   564 AAEEATISPSGLYEMSSLTKASGKLDLLSKMLKQLKAD------------------NHRVLLFSQ 610
            ..|:.|:..|.|:::....|.|.        ||||..|                  .||:|:|.|
Mouse  1595 TTEKLTVQNSSLHDIQHAPKLSA--------LKQLLLDCGLGNGSSTESGTESVVAQHRILIFCQ 1651

  Fly   611 MTKMLNVLEHFL---EGEGYQYDRIDGSIKGDLRQKAIDRF-NDPVSEHFVFLLSTRAGGLGINL 671
            :..||:::||.|   ......|.|:||||....|...:.|| |||..:  |.||:|..||||:||
Mouse  1652 LKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSID--VLLLTTHVGGLGLNL 1714

  Fly   672 ATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVR 736
            ..||||:..:.||||..|:||..||||:|||:.|.:||.:|..::||:||.:.|.||.:.:.|: 
Mouse  1715 TGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVI- 1778

  Fly   737 PGMGGMTTNFSKDELEDILRFGTE---DLF---KDGKSEAIHYDDKAVADLLDRTNRGIEEKES- 794
                       ..|...:...||:   |||   ||||:|.........|.:     :.:.|..| 
Mouse  1779 -----------SQENSSLQSMGTDQLLDLFTLDKDGKAEKADSSTSGKASM-----KSVLENLSD 1827

  Fly   795 -W-ANEYLSSFKVASY 808
             | |.:|.|.:.:.::
Mouse  1828 LWDAEQYDSEYNLETF 1843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Chd3NP_649111.1 PHD2_CHD_II 37..79 CDD:277007 5/24 (21%)
CD_CSD 82..146 CDD:475127 11/73 (15%)
CD2_tandem_CHD3-4_like 176..230 CDD:349309 9/62 (15%)
PLN03142 266..>768 CDD:215601 177/583 (30%)
Btaf1NP_001074175.1 HEAT repeat 285..313 CDD:293787
HEAT 339..453 CDD:441023
HEAT repeat 351..376 CDD:293787
HEAT repeat 389..418 CDD:293787
HEAT repeat 429..459 CDD:293787
HEAT repeat 474..494 CDD:293787
HEAT repeat 505..540 CDD:293787
DUF3535 585..1050 CDD:463447
HEAT repeat 1107..1135 CDD:293787 8/31 (26%)
HEAT repeat 1147..1170 CDD:293787 8/54 (15%)
HEAT repeat 1183..1212 CDD:293787 4/28 (14%)
HepA <1230..1779 CDD:440319 176/602 (29%)
Blue background indicates that the domain is not in the aligned region.

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