Protein Alignment Chd3 and ercc6l

DIOPT Version :10

• Sequence 1: NP_649111.1
• Gene: Chd3 / 40111
• FlyBaseID: FBgn0023395
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_002936822.1
• Gene: ercc6l / 100135235
• XenbaseID: XB-GENE-988849
• Length: 1361
• Species: Xenopus tropicalis
• Alignment Length: 820
• Identity: 225/820 - (27%)
• Similarity: 382/820 - (46%)
• Gaps: 154/820 - (18%)

  Fly   151 EEPSLEELDDQDGNLHERFYRYGIKPEWLLVQR----VINHSEEPNGGTM-----YLVKWRELSY 206
            |.||..  .::.|:||    |..::||  .|:|    |....:|...|.:     :.||..|:..
 Frog     5 ERPSTG--SNEPGDLH----RSRVEPE--QVERYELYVKKAKQEATSGNLEKAIKFFVKASEIHP 61

  Fly   207 NDSSWERESDSIPGLNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGL------ 265
            :|....|    |..|.:|:                   ..:||.:..:|..|.:..:||
 Frog    62 SDKIHRR----IEKLKEAL-------------------EELDLQEDADDDFVDVLNSGLTIYNEL 103

  Fly   266 --KLHPFQIEGVSWLRYSWGQGIP-TILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLST 327
              ||...|.|||::|...:..|.. .||||:||||||||.:.||..:|.....:...|: :|.:.
 Frog   104 YNKLFEHQKEGVAFLYSLYRDGRKGGILADDMGLGKTIQVIGFLSGMFDSELIKYVLLV-MPTTL 167

  Fly   328 LTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFIS 392
            ::||.:|.:.|.|.|            .|...|..|.:|   :|....:.|....:::|:|:.:.
 Frog   168 ISNWVKEFQKWTPGL------------RVAEFHGTSKKE---RTRNLEKIQRMSGIIITTYQMLI 217

  Fly   393 VD----AAFLGC-IDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLL 452
            .:    |.:.|. .:|..:::||||:::::.:|..:.........::||||||:||||.|::.|.
 Frog   218 NNWQQLATYNGREFEWDYIILDEAHKIKTSSTKTAKSCHSIPAKNRILLTGTPIQNNLREMWALY 282

  Fly   453 NFLSSGK-FNDLQTFQAEF---------TDVSKEEQV------KRLHEILEPHMLRRLKADV--- 498
            :|...|. ....:||:.|:         .|.:..|:.      :.|.:|::|:.|||.|:||
 Frog   283 DFACQGTLLGTSKTFKMEYENPITRAREKDATPGEKALGLKISENLMKIIQPYFLRRTKSDVQNK 347

  Fly   499 ---------------LKSMPPKSEFIVRVELSSMQKKFY-KHILTKNFKALNQKGGGRVCSLLNI 547
                           :.|:..|::|||.|.||::|:..| |.|.....|.|.......:.. |||
 Frog   348 KTERTRAQDTSQGPSMPSLTRKNDFIVWVYLSTIQEDVYRKFISLDQIKELLMTTRSPLAE-LNI 411

  Fly   548 MMDLRKCCNHPYLFPSAA--------EEATISPSGLYEMSS---------LTKASGKLDLLSKML 595
               |:|.|:||.|..:.|        ::...:..|.:|:.:         |.:.||||.||..:|
 Frog   412 ---LKKLCDHPRLLSARACIQLGLEGDDYHSNEEGDHELVTKFDHLSDEILIEESGKLLLLIDLL 473

  Fly   596 KQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLL 660
            .:||.:.||.|:|||..|||::::..|:.:.::..||||::....|:|.|..|... :.:.|.||
 Frog   474 HKLKEEGHRTLVFSQSRKMLDMIDRILQNKNFKVMRIDGTVALPEREKRISIFQSN-NNYSVLLL 537

  Fly   661 STRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAK 725
            :|:.||:|:.|..||.|:|||..|||..|.||..||:|:||::.|:|||.:|..:|||:|.:
 Frog   538 TTQVGGVGLTLTAADRVVIFDPSWNPATDAQAVDRAYRIGQQENVVIYRLITCGTVEEKIYR--- 599

  Fly   726 HKMMLTHLVVRPGMGGMTT---NFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNR 787
             :.:....::|...|....   .|||.||:::  |..||  ....|..|...:...|:  .:|:.
 Frog   600 -RQIFKESLIRQTTGDKKNPFRYFSKQELKEL--FSLED--TRTSSTQIQLQNMHAAE--RKTDT 657

  Fly   788 GIEEKESWANEYLSSFKVASY--------ATKEDHEEHDDYNNDAENTDPFYWENLMGKSQ--PK 842
            .::|..::.:. |..|.::.:        :::||:|..|::....|.......|.:..:||  .:
 Frog   658 RLDEHIAYLHT-LQIFGISDHDLVYANELSSQEDNEYEDEHGQYIEQRVQKAHELVQMESQLNEQ 721

  Fly   843 LPKKQKKQSQQSQV-DVESIMGKGKRIRKEIDYSNQYPSP 881
            |..:.:|.::.:.| .:.:...|.|  :..:....||.||
 Frog   722 LMDQIRKSTEGAWVRQISTAPEKPK--KTSLPREKQYSSP 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CD_CSD	82..146	CDD:475127
		CD2_tandem_CHD3-4_like	176..230	CDD:349309	15/62 (24%)
		PLN03142	266..>768	CDD:215601	173/562 (31%)
ercc6l	XP_002936822.1	LapB	<21..123	CDD:442196	28/126 (22%)
		HepA	<106..613	CDD:440319	164/531 (31%)
		DEXHc_ERCC6L	107..339	CDD:350759	69/247 (28%)
		MPH1	<482..753	CDD:440728	81/284 (29%)
		Spy	1305..>1359	CDD:443119