DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd3 and chd4

DIOPT Version :9

Sequence 1:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_012821318.2	Gene:	chd4 / 100124711	XenbaseID:	XB-GENE-995848	Length:	1890	Species:	Xenopus tropicalis

Alignment Length:	959	Identity:	510/959 - (53%)
Similarity:	652/959 - (67%)	Gaps:	101/959 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DPD--------WKTP---------------GKASKDKRPKTNAKKQKFRDEEYCKVCSDGGDLLC 49
            |||        |..|               .:...|........:::....|:|:||.|||:|||
Frog   389 DPDMDKAPEGKWSCPHCEKEGVQWEAKEDNSEIDDDMDDTVGDPEEEDHHMEFCRVCKDGGELLC 453

  Fly    50 CDSCPSVYHRTCLSPPLKSIPKGDWICPRCI--PLPGKAEKILSWRWA-----------LDRSVE 101
            ||:|||.||..||:|||..||.|:|:||||.  .|.||.:|||:|:|.           .|...|
Frog   454 CDACPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKIQKILTWKWGQPPPPTPVPRPADADPE 518

  Fly   102 LRTSK---GEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSLEEL--DDQ 161
            ....|   |...||:|:||..|||.||.|:.|.|:.||...|..::||::||:||...:.  ||:
Frog   519 APPPKPLEGRPEREFFVKWQAMSYLHCSWVTELQLELHCQVMFRNYQRKNDMDEPPAGDYGGDDE 583

  Fly   162 DGN------------LHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSYNDSSWERE 214
            :.:            :.|:||||||||||:::.||:|||.:..|...||:|||:|.|:.:|||.|
Frog   584 EKSRKRKNKDPKYLEMEEKFYRYGIKPEWMMIHRVLNHSVDKKGFVHYLIKWRDLPYDQASWESE 648

  Fly   215 SDSIPGLN---QAIALYKKLRSSNKGR-------------QRDRPAPTIDLNKKYEDQPVFLKEA 263
            ...|...:   ||...:::|...::||             :|....|.:|...||:.||.:|...
Frog   649 ESDIQDYDIYRQAYWNHRELMCGDEGRPGKKTKKVKLRKVERPPDTPAVDPTVKYDRQPEYLDAT 713

  Fly   264 GLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTL 328
            |..|||:|:||::|||:||.||..||||||||||||:||.||||||:||||.:||||:|.||||:
Frog   714 GGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTI 778

  Fly   329 TNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTK-----TMRENQTQYKFNVMLTSY 388
            .|||||.|:|||::|.|||||.|.:|||||::|.|||:...:     :..:.:...||:|:||||
Frog   779 INWEREFEMWAPDMYVVTYVGDKDSRAVIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSY 843

  Fly   389 EFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLN 453
            |.|::|.|.||.||||.|||||||||::|||||||:|:.|.:.:|||||||||||||||||||||
Frog   844 ELITIDMAVLGSIDWACLVVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLN 908

  Fly   454 FLSSGKFNDLQTFQAEFTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQ 518
            ||:..:||:|:.|..||.|::||:|:|:||::|.|||||||||||.|:||.|:|.|||||||.||
Frog   909 FLTPERFNNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQ 973

  Fly   519 KKFYKHILTKNFKALNQKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATISPSGLYEMSSLTK 583
            ||:||.|||:||:|||.:|||...||||::|||:||||||||||.||.||...|:|:|:.|:|.|
Frog   974 KKYYKFILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIK 1038

  Fly   584 ASGKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRF 648
            .:|||.||.|||::||.|.||||:||||||||::||.|||.|||:|:||||.|.|::||:|||||
Frog  1039 GAGKLLLLQKMLRKLKDDGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRF 1103

  Fly   649 NDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTH 713
            |.|.::.|.||||||||||||||||||||:|:|||||||||:||||||||:||.||||||||||.
Frog  1104 NAPGAQQFCFLLSTRAGGLGINLATADTVVIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTR 1168

  Fly   714 NSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSE--------- 769
            .||||||.||||.||||||||||||:|..|.:.||.||:|||:||||:||||..:|
Frog  1169 ASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATEENKEGDDIS 1233

  Fly   770 AIHYDDKAVADLLDRTNRGIEE--KESWANEYLSSFKVASYATKE----DHEE-HDDYNNDAENT 827
            .|||||||:|.||||.....|:  :....||||||||||.|..:|    |.|| ..:.....|:.
Frog  1234 VIHYDDKAIARLLDRNQDETEDLVELQGMNEYLSSFKVAQYVVREEEMGDEEEVVREIIKQEESV 1298

  Fly   828 DPFYWENLMGKSQPKLPKKQKKQSQQSQVDVESIMGKGKRIRKEIDYSN 876
            ||.|||.|:           :...:|.|.|:...:||||||||:::|::
Frog  1299 DPDYWEKLL-----------RHHYEQQQEDLARNLGKGKRIRKQVNYND 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	27/41 (66%)
		CHROMO	85..147	CDD:237991	27/75 (36%)
		CHROMO	181..233	CDD:214605	21/54 (39%)
		SNF2_N	270..561	CDD:278600	194/295 (66%)
		DEXDc	288..440	CDD:238005	99/156 (63%)
		Helicase_C	585..700	CDD:278689	86/114 (75%)
chd4	XP_012821318.2	CHDNT	147..200	CDD:400425
		PHD1_CHD_II	363..405	CDD:277006	5/15 (33%)
		PHD2_CHD_II	441..483	CDD:277007	27/41 (66%)
		CD1_tandem_CHD3-4_like	488..566	CDD:349314	28/77 (36%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	23/53 (43%)
		PLN03142	715..>1256	CDD:215601	361/540 (67%)
		DEXHc_CHD4	717..948	CDD:350814	147/230 (64%)
		DUF1087	1289..1334	CDD:399459	18/55 (33%)
		DUF1086	1371..1510	CDD:368921
		fibronec_FbpA	<1506..>1603	CDD:411474
		CHDCT2	1704..1829	CDD:400426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4565
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35578at33208
OrthoFinder	1	1.000	-	-		FOG0000546
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45623
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110