DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32206 and CUBN

DIOPT Version :9

Sequence 1:	NP_788538.2	Gene:	CG32206 / 40105	FlyBaseID:	FBgn0052206	Length:	1278	Species:	Drosophila melanogaster
Sequence 2:	NP_001072.2	Gene:	CUBN / 8029	HGNCID:	2548	Length:	3623	Species:	Homo sapiens

Alignment Length:	1552	Identity:	272/1552 - (17%)
Similarity:	437/1552 - (28%)	Gaps:	675/1552 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VSEFSCK-GSGNSGTICVP-----LDKYCDGRSDCADGSDE----------------PKHCSVCN 93
            ||.:.|| .||.:|..|..     |...|.....|.||.|.                |:  .||.
Human   413 VSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQ--QVCG 475

  Fly    94 RTYYG----------DIGRTYAIKVPTPQWNKLPFLCHLTFTASGHDQGDIVQIIFDGFTVGRFD 148
            .:..|          |:|..:.:.            |   |.....:.|.:::|.|..|.:...|
Human   476 ESLSGINGSFSYRSPDVGYVHDVN------------C---FWVIKTEMGKVLRITFTFFRLESMD 525

  Fly   149 EGMVDTDVDGYETNLSPTGELPGCPEGFMQL--SELGRPFTGGSWCGKATGPQLYFSETSTVTAS 211
                                  .||..|:|:  .:....|..|.:||.:...:|..|:.:.
Human   526 ----------------------NCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNAL---- 564

  Fly   212 VKVFH-PPRNIRDEKPFEFSIRYKFISQSDAVVRYGLPDKPLELGRVTPGTYCTRQFDECYRNKC 275
              .|| ...::|:.:  .|::|::             ..:| |.|.:..|.|.:
Human   565 --YFHLYSEHLRNGR--GFTVRWE-------------TQQP-ECGGILTGPYGS----------- 600

  Fly   276 RLQSPNYPGMYPRNVTCYWTIRQKEVPTSKHAMIAVSQENQHKALVKRSIASFNKTSRSIRAWSD 340
             ::||.|||.||....|.|.     |.||...::                 :|...:.|:....|
Human   601 -IKSPGYPGNYPPGRDCVWI-----VVTSPDLLV-----------------TFTFGTLSLEHHDD 642

  Fly   341 CTGERDHLIFYDGSSTNDPVLAKYCGGDWLPRVVSRGPEMLVAFHSSPFSAPLQQGIPNRGFEL- 404
            |  .:|:|...||....||:|.|:|....:|.:.:.||...:.|||       ...|.::||.:
Human   643 C--NKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHS-------DSQISDQGFHIT 698

  Fly   405 ----------------------------------------------DVDILFTDSDSFDFAQGTK 423
                                                          .:.|.||..:....:..::
Human   699 YLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQ 763

  Fly   424 NLCE------------------------------FHINASNP------------DDVLFSRRGRM 446
            |..|                              |.|:||..            .|.|...
Human   764 NYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGE---- 824

  Fly   447 GRIVSP--RHTLPPNTTCTYHFHGYPGDLIWLSFTSYNLQILQQAIHDNNTLGRS---------- 499
            |.|.||  .:..|...||.:..|.....:|.|:||.:.:........|...:|.|
Human   825 GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKK 889

  Fly   500 ----DLPPWITRLRMWDSYGTYVPMKST----------------------SSTTGQPPPPPPVAS 538
                |:|.:||.:..: .|.|:|...||                      |:.|.|.|..|.|..
Human   890 YCGTDIPSFITSVYNF-LYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYP 953

  Fly   539 SADGGKPTLLNQSN----------YGSYYYSASN-----------------------PKL----- 565
            ........:|.|.|          :..::|:.:|                       |.|
Human   954 HGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGN 1018

  Fly   566 ------------------------------------------NRNLRVNIDNAW----------- 577
                                                      :.|...|..|.|
Human  1019 SLMLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTG 1083

  Fly   578 ---------------------------------NPVDTYIYG----PTQSSVFNQENK------- 598
                                             :|:....||    ||   :.:..||
Human  1084 QLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPT---IISHSNKLWLKFKS 1145

  Fly   599 --------YSGYQGGGPGGGSTGSAGSGKTISGVKDSLNYISSGKSSKEVSAAAVVSSDRNSAVA 655
                    :|.|.    .|.|||..|:..|.||...|.||......|.|  ....:.|...||
Human  1146 DQIDTRSGFSAYW----DGSSTGCGGNLTTSSGTFISPNYPMPYYHSSE--CYWWLKSSHGSA-- 1202

  Fly   656 LMSTKGKRRLMLEIYDY--ETPKLC--DHTAIGSGVSGSSAVMG---GNKQRP---CSPLESYV- 709
                     ..||..|:  |....|  |:.|:..|.|.:|.::.   |:::.|   .|....::
Human  1203 ---------FELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIK 1258

  Fly   710 ------STGRDLKLEFHTHTGTAL-------------FPAQFA----------------LNYEFV 739
                  ..||..|.|:.......:             :|..::                :||.|:
Human  1259 LRTDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFL 1323

  Fly   740 --DTEQ------------GGETWAGRR-GEDPVPP------------LCSRIFKKRKGNIQVPRN 777
              |.|.            .|....||. |.|..||            |...:.::.||   ....
Human  1324 AFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKG---FQMQ 1385

  Fly   778 VFLYGRGG------------------AKNITCLYRFEAGPSERVKLVLHNVSFGEGTACTTD--- 821
            .|:||.||                  ..|..|::.....|...::|.:|:......:.|..|
Human  1386 WFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450

  Fly   822 ----SDLHTGRPR----CNQLDPEGRI--------------TEL----RLFDVPFRDVKIQLGC- 859
                .|.|:  ||    |.|..||..:              |:|    |.|:..::  .:..||
Human  1451 IYGGPDFHS--PRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQ--AVTGGCG 1511

  Fly   860 --FCDNSSALYS-NAPLTFVSHS------------RIMELSFTVTRLNISEDFADVFFSASYEFK 909
              |...|..::| |.|..:.|::            |:: |:||                 .::.:
Human  1512 GIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVL-LNFT-----------------DFDLE 1558

  Fly   910 RQPDC--------RKQLKLKGAGGEDELKYPLKTQDASCEGLAWYIEAQSAE-------RSLFVQ 959
            .|..|        ....:|....|.::|..|:.:     .|.:.::..||..       |:.|.|
Human  1559 PQDSCIMAYDGLSSTMSRLARTCGREQLANPIVS-----SGNSLFLRFQSGPSRQNRGFRAQFRQ 1618

  Fly   960 TWGAYLPVDPTSEDAMRCHTKNRLMIYSGRPLRPMRVVCPAQSGPRPMSLHIFSEDWTNGQPLFM 1024
            ..|.::..  :|.|.:                          |.||      |..::.|.|
Human  1619 ACGGHILT--SSFDTV--------------------------SSPR------FPANYPNNQ---- 1645

  Fly  1025 NKPISLVLEPILKEPGDISFTWLEIHRTKNALLQQLDL----HVNASV------------TTGMG 1073
            |....:..:|.|... .:|||..|:.|:.......:::    |.:|.:            .|...
Human  1646 NCSWIIQAQPPLNHI-TLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFS 1709

  Fly  1074 SQTSSQSAAGSNTGIGGLGTSGSGSAANAGGSAGGATANETLNEFGF---FPKESDC 1127
            |..:.:..:.|:...||..|:.:.|.:..||:.  ..|....|..|:   :|...:|
Human  1710 SALTLRFVSDSSISAGGFHTTVTASVSACGGTF--YMAEGIFNSPGYPDIYPPNVEC 1764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32206	NP_788538.2	LDLa	49..85	CDD:197566	13/39 (33%)
CG32206	NP_788538.2	CUB	276..404	CDD:238001	34/127 (27%)
CUBN	NP_001072.2	Interaction with AMN. /evidence=ECO:0000269\|PubMed:30523278	42..49
		EGF_CA	136..167	CDD:238011
		EGF_CA	170..210	CDD:238011
		EGF_CA	263..304	CDD:214542
		EGF_3	309..347	CDD:289699
		EGF_3	353..387	CDD:289699
		EGF_CA	399..430	CDD:238011	7/16 (44%)
		EGF_CA	432..468	CDD:238011	6/35 (17%)
		CUB	474..585	CDD:238001	26/168 (15%)
		CUB	590..699	CDD:238001	37/151 (25%)
		CUB	708..815	CDD:238001	9/106 (8%)
		CUB	817..927	CDD:238001	26/114 (23%)
		CUB	932..1041	CDD:238001	13/108 (12%)
		CUB	1048..1157	CDD:294042	12/111 (11%)
		CUB	1165..1275	CDD:238001	29/122 (24%)
		CUB	1282..1388	CDD:238001	16/108 (15%)
		CUB	1391..1505	CDD:238001	21/117 (18%)
		CUB	1510..1617	CDD:238001	21/129 (16%)
		CUB	1620..1733	CDD:238001	25/151 (17%)
		CUB	1738..1847	CDD:238001	7/29 (24%)
		CUB	1859..1962	CDD:238001
		CUB	1978..2088	CDD:278839
		CUB	2092..2212	CDD:238001
		CUB	2217..2333	CDD:238001
		CUB	2336..2447	CDD:238001
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3621	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47537
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100