DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32206 and sol-1

DIOPT Version :9

Sequence 1:	NP_788538.2	Gene:	CG32206 / 40105	FlyBaseID:	FBgn0052206	Length:	1278	Species:	Drosophila melanogaster
Sequence 2:	NP_492088.3	Gene:	sol-1 / 172493	WormBaseID:	WBGene00004944	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	151/762 - (19%)
Similarity:	240/762 - (31%)	Gaps:	265/762 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LLVVLLATTLGLACRVSEFSCKGSGNSGTICVPLDKYCDGRSDCADGSDEPKHCSVCNRTYYGDI 100
            |:::|:....|.....||..||                               |.:.|.|    .
Worm     8 LVLLLIPILFGYFSHASEHECK-------------------------------CVLFNVT----S 37

  Fly   101 GRTYAIKVPTPQWNKLPFLCHLTFTASGHDQGDIVQIIFDGF----TVGRFDEGMV--DTDVDGY 159
            |..::.:.|.| ...:|.|.:.......|    |:::.||.|    .:|.....::  |...||
Worm    38 GNFHSPEFPAP-LEGVPCLFYHFQAPPDH----IIRLTFDVFQLPPRIGVCSSSIMLFDHSTDG- 96

  Fly   160 ETNLSPTGELPGCPEGFMQLSELGRPFTGGSWCGK--ATGPQLYFSETSTVTASVKVFHPPRNIR 222
                               |.|.|.. ....:|||  ::|.| :||:..         |....|.
Worm    97 -------------------LIEFGER-ADFEFCGKEISSGRQ-FFSKDQ---------HFLLQIS 131

  Fly   223 DEKPFEFSIRYKFIS------QSDAVVRYGLPDKPLELGRVTPGTYCTRQFDEC-YR---NKCRL 277
            ..|......|..|::      .||||                       :..|| ||   .|..:
Worm   132 SGKESSRGFRGSFLAIPKKNFTSDAV-----------------------EMAECSYRVEKQKAII 173

  Fly   278 QSPNYPGMYPRNVTCYWTIRQKE----------VPTSKHAMIAVSQENQHKALVKRSIASFNKTS 332
            .||:||..||..|.|.:.|.|::          :...:.|::.:.:..:.| ..||.|.......
Worm   174 YSPDYPYYYPSKVNCTYHIPQRKGFQIVVNSIVMDIGRDAILQIFESVEGK-FEKRLIEMVTSVQ 237

  Fly   333 RSIRAWSDCTGERDHLIFYDGSSTNDPVLA-------KYCGGDWLPRVVSRGPEMLVAFHSSPFS 390
            :||...|..:     |:.|..:..||...|       :|....|     |:.||
Worm   238 KSIYVSSTSS-----LLIYFSAGNNDVERAVGFVIELQYSNAVW-----SQSPE----------- 281

  Fly   391 APLQQGIPNRGFELDVDILFTDSDSFDFAQGTKNLCEFHINASNPDDVLFSRRGRMGRIVSPRHT 455
                                           |.:.|:.:||:.|..:...| ..::||..|  .:
Worm   282 -------------------------------TASECQLNINSENFKEGQLS-SDKIGRFTS--SS 312

  Fly   456 LPPNTTCTYHFHGYPGDLIWLSFTSYNLQILQQAIHDNNTLGRSDLPPWITRLRMWDSYGTYVPM 520
            ||  |.|.....|||.:.|.:.||.:||.     :.||..:.:        |....|:....|.:
Worm   313 LP--TKCQIVLQGYPNEKISVKFTHFNLY-----VPDNKNVTK--------RCTEVDNLSADVRV 362

  Fly   521 KSTSST----TGQPPPPPPVASSADGGKPTLLNQSNYGSYYYSASNPKLNRNLRVNID----NAW 577
            .|..|.    .|:..||..::||.       |.|..|.:....|.....|.::...:|    ..|
Worm   363 GSRLSRIDEWCGKRAPPNLMSSSN-------LLQLEYNTKSSKAIRESTNDDIGFRLDYKFHTDW 420

  Fly   578 NPVDTYIYGPTQSSVFNQENKYSGYQGGGPGGGSTGSAGSGKTISGVKDSLNYISSGKSSKEVSA 642
            |      .|..::.|  .:.|...:           |..|.:..:|...|.||  .|...:.:..
Worm   421 N------MGNMKAKV--DKKKECRF-----------SFNSSEHTNGKLWSANY--PGLYPRNLYC 464

  Fly   643 AAVVSSDRNSAVALMSTKGKRRLMLEIYDYETPKLCDHTAIGSGVSGSSAVMGGNKQ-------R 700
            ..:... ||..|.        .:..|.:|.|....||.|      :.|..::..|.|       |
Worm   465 EYIFHG-RNDQVV--------HIHFEYFDIEGFNQCDET------TQSDYILFSNYQTHDRTNRR 514

  Fly   701 PC---SPLESYVSTGRDLKLEFHTHTGTALFPAQ-FALNYEFVDTEQ 743
            .|   :|....:|.....::.|.|:.   :|.|. |..:|:|:..|:
Worm   515 FCGKTAPKGPILSESNYFRMIFSTND---IFDATGFYAHYQFITQEK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32206	NP_788538.2	LDLa	49..85	CDD:197566	4/35 (11%)
CG32206	NP_788538.2	CUB	276..404	CDD:238001	28/144 (19%)
sol-1	NP_492088.3	CUB	28..144	CDD:294042	33/186 (18%)
		CUB	298..416	CDD:238001	34/142 (24%)
		CUB	447..551	CDD:214483	26/123 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47537
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100