DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pip and UST

DIOPT Version :9

Sequence 1:	NP_788536.1	Gene:	pip / 40104	FlyBaseID:	FBgn0003089	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_005706.1	Gene:	UST / 10090	HGNCID:	17223	Length:	406	Species:	Homo sapiens

Alignment Length:	316	Identity:	90/316 - (28%)
Similarity:	157/316 - (49%)	Gaps:	47/316 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 FKADL---LNNTKYAE---------VDF---VFFNRVPKVGSQSLMELMARLGKINGFTHARNKG 250
            |..||   |.|:.|.:         :.|   |.:|||.|.||::::.|:..|.:.:||....:
Human    74 FLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVLLLRILSEKHGFNLVTS-- 136

  Fly   251 SAHETIVMNKQRQNDLIADLLTRPKPHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYY 315
            ..|....:.|..|.:||.::.|..:|:::::|:.::||:||...:|:|||:||||::|.:| :|:
Human   137 DIHNKTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGDQPVYINIIRDPVNRFLS-NYF 200

  Fly   316 IRAPWYYRDMQAKLGENAIPMPS--EEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFF 378
            .|....:|..|    .:.|..||  :|...||::.|:..:.|.|:..::....|         :|
Human   201 FRRFGDWRGEQ----NHMIRTPSMRQEERYLDINECILENYPECSNPRLFYIIP---------YF 252

  Fly   379 CGMNQKLCMPFNSEAAMQKAKRTVETEYAVVGTWEDTNITLSVLEAYIPRYFRNAKVAYYLGKDR 443
            ||.:.:...|  .|.|:::||..|...:.:||..|:....|.:||.::|.||:.....|   ||.
Human   253 CGQHPRCREP--GEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPHYFKGVLSIY---KDP 312

  Fly   444 LSRVNRNNVT-----RIVSDETRLILRKNLTNEIEFYEFCKQRLYL---QYAALSH 491
            ..| ...|:|     .:.|.|...||.:.:..|.|||.:.|::.:|   ::...||
Human   313 EHR-KLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKRKFGLKSH 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pip	NP_788536.1	Sulfotransfer_2	212..477	CDD:281554	80/283 (28%)
UST	NP_005706.1	Sulfotransfer_2	104..356	CDD:328972	80/273 (29%)
UST	NP_005706.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375927at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12129
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810