DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHOX2A and Drgx

DIOPT Version :9

Sequence 1:	NP_005160.2	Gene:	PHOX2A / 401	HGNCID:	691	Length:	284	Species:	Homo sapiens
Sequence 2:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	289	Identity:	101/289 - (34%)
Similarity:	128/289 - (44%)	Gaps:	94/289 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    40 PAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHE----KRKQRRIRTTFTSA 100
            ||....||..|.|.:.:....|..     ||::  |.:.|   .:|:    :|||||.|||||..
  Fly     8 PALHPCGPHPPRLPTLDYPFAATH-----PYTS--YSYHP---AIHDETFVRRKQRRNRTTFTLQ 62

Human   101 QLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKK 165
            ||:|||..||:|||||::|||:||:||:||||||||||||||||:||.||....:       .|:
  Fly    63 QLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQ-------RKR 120

Human   166 GEARCSSEDD---DSKESTCSPTPDSTA-------SLPP------PPAPG--------------- 199
            .....||..|   ||:||    :||.|.       .|||      |.|.|
  Fly   121 ENGESSSSLDKLHDSRES----SPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHS 181

Human   200 -----------------LASPRLSPSP--LPVALGSGPGPGPGPQ---------PLKGALWAGVA 236
                             |:|.:|:.:|  ...:|||.....|.|.         ||        .
  Fly   182 RSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPL--------V 238

Human   237 GGGGGGPGAGAAELLKAWQPAESGPGPFS 265
            ||||.|| :..:.......|.|.| ||.|
  Fly   239 GGGGQGP-SSPSNSRNTDSPIEVG-GPMS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHOX2A	NP_005160.2	Homeobox	94..147	CDD:365835	40/52 (77%)
PHOX2A	NP_005160.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..284		44/180 (24%)
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	40/51 (78%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910