DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALD5

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_010996.2	Gene:	ALD5 / 856804	SGDID:	S000000875	Length:	520	Species:	Saccharomyces cerevisiae

Alignment Length:	463	Identity:	132/463 - (28%)
Similarity:	225/463 - (48%)	Gaps:	21/463 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEAYK-QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVS 131
            :|...:.|..|.:....:::..:..|.:|:: :|..|...||.:.:..:.|.:.|::|.|..:.|
Yeast    65 NPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPEVRAKALFNLADLVEKHQETLAAIES 129

  Fly   132 LEVGKIYSEGQGE---VQEFIDIC-DYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAY 192
            ::.||.....:|:   |.:::..| .:|   .:|| |.:|::.: :|.......||||.|.|..:
Yeast   130 MDNGKSLFCARGDVALVSKYLRSCGGWA---DKIY-GNVIDTGK-NHFTYSIKEPLGVCGQIIPW 189

  Fly   193 NFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVG 255
            |||..::.|....||.|||:|:.|.|.:|||.::..:::..|.    .:|. ||.:..| |..||
Yeast   190 NFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEA----GIPAGVVNILPGSGRVVG 250

  Fly   256 QTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCI 320
            :.|.|...|..::||||..|||.:.........||.|||||.:..|:...|::..|:....||..
Yeast   251 ERLSAHPDVKKIAFTGSTATGRHIMKVAADTVKKVTLELGGKSPNIVFADADLDKAVKNIAFGIF 315

  Fly   321 GTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIA 385
            ..||:.|....||.:.:.::::.:::|....:.|  |:|...:.:...|...:.:.:......:.
Yeast   316 YNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESL--KVGDPFDEEVFQGAQTSDKQLHKILDYVD 378

  Fly   386 EAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEV 450
            .|||.|..:..||......|::|:|||...:..|..:|..|.|.|||.:.|...||:.|...|:.
Yeast   379 VAKSEGARLVTGGARHGSKGYFVKPTVFADVKEDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDS 443

  Fly   451 EQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQY 515
            :.||::.|.|.:|.:|..  .:|....|.|.|||..|..: ...|||...:|.|||.|..|...|
Yeast   444 QYGLAAGIHTNDINKAVD--VSKRVKAGTVWINTYNNFHQ-NVPFGGFGQSGIGREMGEAALSNY 505

  Fly   516 CKRATITV 523
            .:..::.:
Yeast   506 TQTKSVRI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	132/463 (29%)
ALD5	NP_010996.2	ALDH_F1-2_Ald2-like	41..513	CDD:143410	132/461 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810