DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and MSC7

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_011904.1	Gene:	MSC7 / 856434	SGDID:	S000001081	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	112/552 - (20%)
Similarity:	210/552 - (38%)	Gaps:	94/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTS------------YDPGTGQPIAKVR 79
            ||||          |.:......|......|:|:....|:            :.|.|||.:....
Yeast    73 SSSY----------KPVKFSLPAPEAAQNNWKGKRSVSTNIWNPEEPNFIQCHCPATGQYLGSFP 127

  Fly    80 QGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGK-IYSEGQG 143
            .....:::..:..|.:|...|.......|..::..:.|.:...::.:.::...:.|| :.....|
Yeast   128 SKTEADIDEMVSKAGKAQSTWGNSDFSRRLRVLASLHDYILNNQDLIARVACRDSGKTMLDASMG 192

  Fly   144 EVQEFIDICDYAVG-----------------LSRIYSGQLINSERADHSILEAWRPLGVVGVISA 191
            |:...::...:.:.                 ..:.|.|..|..|           ||||:..|.:
Yeast   193 EILVTLEKIQWTIKHGQRALQPSRRPGPTNFFMKWYKGAEIRYE-----------PLGVISSIVS 246

  Fly   192 YNFP-NAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRR-----NNLPPVVTLC-- 248
            :|:| :.:.|...| ||.|||:::.|.:...    |.:::...|::|:     :..|.:|.||
Yeast   247 WNYPFHNLLGPIIA-ALFTGNAIVVKCSEQV----VWSSEFFVELIRKCLEACDEDPDLVQLCYC 306

  Fly   249 ---QGGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKM 310
               ....|......:......::|.||......:.....:....|::||||.:|.|:.:||....
Yeast   307 LPPTENDDSANYFTSHPGFKHITFIGSQPVAHYILKCAAKSLTPVVVELGGKDAFIVLDSAKNLD 371

  Fly   311 ALDAALF-GCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLE--AQTLVGPVH 372
            ||.:.:. |...:|||.|....|:||.::.:|..||.|..:......:.|..::  ....:|.:.
Yeast   372 ALSSIIMRGTFQSSGQNCIGIERVIVSKENYDDLVKILNDRMTANPLRQGSDIDHLENVDMGAMI 436

  Fly   373 TQQNVENYKAAIAEAKSLGGTVAFGGNVIQR----DGFYVEPTVITGLPHDASVVHRETFAPIVY 433
            :....:..:|.:.:|.:.|..:..||:..:.    .|.|.:||::..:..:..:...|.|.||:.
Yeast   437 SDNRFDELEALVKDAVAKGARLLQGGSRFKHPKYPQGHYFQPTLLVDVTPEMKIAQNEVFGPILV 501

  Fly   434 ILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGG----- 493
            ::||||.|..::..|....||..::|           ||...:|..|..:..|....|..
Yeast   502 MMKAKNTDHCVQLANSAPFGLGGSVF-----------GADIKECNYVANSLQTGNVAINDFATFY 555

  Fly   494 ----AFGGEKATGGGRESGSDAWKQYCKRATI 521
                .|||...:|.|:..|.:.....|...::
Yeast   556 VCQLPFGGINGSGYGKFGGEEGLLGLCNAKSV 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	106/528 (20%)
MSC7	NP_011904.1	ALDH_F15-22	115..590	CDD:143416	103/500 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900