DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALD4

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_015019.1	Gene:	ALD4 / 854556	SGDID:	S000005901	Length:	519	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	149/516 - (28%)
Similarity:	243/516 - (47%)	Gaps:	32/516 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QLRNISKLALPRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYD 68
            |||..|.|.:       |......:....:||       .||..:|..|.|.|    ..:....:
Yeast    20 QLRYFSHLPM-------TVPIKLPNGLEYEQP-------TGLFINNKFVPSKQ----NKTFEVIN 66

  Fly    69 PGTGQPIAKVRQGNVQELEHTIGLAVEAYK--QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVS 131
            |.|.:.|..:.:|...::|..:..|..|:.  .|..:....||:.:.::.:.:.:.|:.:..:.:
Yeast    67 PSTEEEICHIYEGREDDVEEAVQAADRAFSNGSWNGIDPIDRGKALYRLAELIEQDKDVIASIET 131

  Fly   132 LEVGKIYSEGQGEVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPN 196
            |:.||..|..:|:|...|:....:.|.:....|::|::.|...|..:. :||||.|.|..:|||.
Yeast   132 LDNGKAISSSRGDVDLVINYLKSSAGFADKIDGRMIDTGRTHFSYTKR-QPLGVCGQIIPWNFPL 195

  Fly   197 AVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVGQTLV 259
            .::.|..|.||.|||:|:.|.|.||||.::..:|.:.:.    .:|| |:.:..| |..||:.:.
Yeast   196 LMWAWKIAPALVTGNTVVLKTAESTPLSALYVSKYIPQA----GIPPGVINIVSGFGKIVGEAIT 256

  Fly   260 ADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSG 324
            ...::..|:||||..|||.:.........||.|||||.:..|:...|.:|.|:...:.|....||
Yeast   257 NHPKIKKVAFTGSTATGRHIYQSAAAGLKKVTLELGGKSPNIVFADAELKKAVQNIILGIYYNSG 321

  Fly   325 QRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKS 389
            :.|....|:.|.|.::|:|::|.....:.:  |:|...:..|..|...:|..:......:...|:
Yeast   322 EVCCAGSRVYVEESIYDKFIEEFKAASESI--KVGDPFDESTFQGAQTSQMQLNKILKYVDIGKN 384

  Fly   390 LGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGL 454
            .|.|:..||..:...|::::|||...:..|..:|..|.|.|:|.:.|.|:.|:.|...|:.|.||
Yeast   385 EGATLITGGERLGSKGYFIKPTVFGDVKEDMRIVKEEIFGPVVTVTKFKSADEVINMANDSEYGL 449

  Fly   455 SSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQY 515
            ::.|.|.||..|.|  .|...:.|.|.|| |.|.......|||..|:|.|||...||.:.|
Yeast   450 AAGIHTSNINTALK--VADRVNAGTVWIN-TYNDFHHAVPFGGFNASGLGREMSVDALQNY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	138/469 (29%)
ALD4	NP_015019.1	ALDH_F1-2_Ald2-like	42..514	CDD:143410	143/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740