DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH7B4

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_175812.1	Gene:	ALDH7B4 / 841849	AraportID:	AT1G54100	Length:	508	Species:	Arabidopsis thaliana

Alignment Length:	505	Identity:	269/505 - (53%)
Similarity:	366/505 - (72%)	Gaps:	7/505 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EYSFLKELGLERDNPGVY-SGQWQGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQ 99
            ||.||.|:||...|.|.| :|:||..||.|::.:|...||||:|.:.::::.|..:....||.|.
plant     7 EYEFLSEIGLTSHNLGSYVAGKWQANGPLVSTLNPANNQPIAQVVEASLEDYEQGLKACEEAAKI 71

  Fly   100 WRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQGEVQEFIDICDYAVGLSRIYSG 164
            |.||.||.||:|||||||.||...:.||:|:|||:|||.:||.|||||.||:||:||||||..:|
plant    72 WMQVTAPKRGDIVRQIGDALRSKLDYLGRLLSLEMGKILAEGIGEVQEVIDMCDFAVGLSRQLNG 136

  Fly   165 QLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATT 229
            .:|.|||.:|.:||.|.|||:||||:|:|||.||.||||.|||..||.|:|||||:|||:::|.|
plant   137 SVIPSERPNHMMLEMWNPLGIVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMT 201

  Fly   230 KIVAEVLRRNNLPPVV--TLCQGGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVIL 292
            |:|||||.:||||..:  .:| ||.::|:.:..|.|:.|||||||.:.|..|...|..|.||.:|
plant   202 KLVAEVLEKNNLPGAIFTAMC-GGAEIGEAIAKDTRIPLVSFTGSSRVGSMVQQTVNARSGKTLL 265

  Fly   293 ELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISK 357
            ||.||||:|:.:.|::::|..:.||..:||:||||||.||:::||.::|:.:::|:..|||:  |
plant   266 ELSGNNAIIVMDDADIQLAARSVLFAAVGTAGQRCTTCRRLLLHESVYDKVLEQLLTSYKQV--K 328

  Fly   358 IGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASV 422
            ||:.||..||:||:||.::.:|::..|...||.||.:..||..::.:|.:||||:|. :..||:|
plant   329 IGNPLEKGTLLGPLHTPESKKNFEKGIEVIKSQGGKILTGGKAVEGEGNFVEPTIIE-ISADAAV 392

  Fly   423 VHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTN 487
            |..|.|||::|:||.|:..:|:..||.|.|||||:|||.|....|:|||..||||||||:|..||
plant   393 VKEELFAPVLYVLKFKSFGEAVAINNSVPQGLSSSIFTRNPENIFRWIGPLGSDCGIVNVNIPTN 457

  Fly   488 GAEIGGAFGGEKATGGGRESGSDAWKQYCKRATITVNHSGELACAQGVVF 537
            |||||||||||||||||||:|||:||||.:|:|.|:|:..||..|||:.|
plant   458 GAEIGGAFGGEKATGGGREAGSDSWKQYMRRSTCTINYGNELPLAQGINF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	255/477 (53%)
ALDH7B4	NP_175812.1	PLN02315	1..508	CDD:177949	269/505 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	497	1.000	Domainoid score	I76
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H913
Inparanoid	1	1.050	544	1.000	Inparanoid score	I262
OMA	1	1.010	-	-		QHG63481
OrthoDB	1	1.010	-	-		D692580at2759
OrthoFinder	1	1.000	-	-		FOG0006553
OrthoInspector	1	1.000	-	-		oto3721
orthoMCL	1	0.900	-	-		OOG6_103382
Panther	1	1.100	-	-	LDO	PTHR43521
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840