DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH5A1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_733936.1	Gene:	ALDH5A1 / 7915	HGNCID:	408	Length:	548	Species:	Homo sapiens

Alignment Length:	482	Identity:	134/482 - (27%)
Similarity:	230/482 - (47%)	Gaps:	32/482 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GQWQGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDEL 119
            |:|.....:....||.:|..:..|....|:|....:..|.||:.:||:|.|..|..::|:..:.:
Human    67 GRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131

  Fly   120 RKYKEPLGKLVSLEVGKIYSEGQGEV---QEFIDICDYAVGLSRIYSGQLINSERADHSILEAWR 181
            .:.|:.|.::::.|.||...|..||:   ..|::.  ::....|:| |.:|::...|...|...:
Human   132 IQNKDDLARIITAESGKPLKEAHGEILYSAFFLEW--FSEEARRVY-GDIIHTPAKDRRALVLKQ 193

  Fly   182 PLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPPVVT 246
            |:||..||:.:|||:|:.......||..|.:|:.|.|..||..::|..::....|.  :|.|::.
Human   194 PIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLL--DLDPLLL 256

  Fly   247 LCQGG----------------TDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELG 295
            ..|.|                .:||:.:..|..|:.:|||||..||:.:.........:|.:|||
Human   257 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG 321

  Fly   296 GNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGH 360
            |....|:.:||||..|:..|:......:||.|..:.:.:|...:||.|||......|:.: ::|:
Human   322 GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL-RVGN 385

  Fly   361 QLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHR 425
            ..|..|..||:..::.||..:..:.:|.|.|.||..||...|....:.|||::..:..|....|.
Human   386 GFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 450

  Fly   426 ETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNG-- 488
            |||.|:..::|....::||...|..:.||:...::::..|.  |..|:..:.|:|.:|   .|
Human   451 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVN---EGLI 510

  Fly   489 AEIGGAFGGEKATGGGRESGSDAWKQY 515
            :.:...|||.|.:|.|||.......:|
Human   511 SSVECPFGGVKQSGLGREGSKYGIDEY 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	134/482 (28%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	132/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810