DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and aldh1a3

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	490	Identity:	135/490 - (27%)
Similarity:	232/490 - (47%)	Gaps:	29/490 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SGQW--QGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQ---WRQVPAPVRGEIVR 113
            :.:|  ..:|....:.:|.||..|..:.:.:..:::..:..|..|.::   ||::.|..||.::.
Zfish    37 NNEWHTSSKGKQFPTINPATGVKICDIEEADKADVDEAVKAAKAAGQRGSVWRRMDASSRGRLLN 101

  Fly   114 QIGDELRKYKEPLGKLVSLEVGKIYSEGQGEVQEFIDICDYAVGLSRIYSG--QLINSER--ADH 174
            ::.|.|.:.:..|..|.|.:.||.:...     .|:|: |.::...|.|:|  ..|:.:.  .|.
Zfish   102 RLADLLERERAVLATLESKDTGKPFLHA-----FFVDL-DGSIKTLRYYAGWTDKIHGKTMPVDE 160

  Fly   175 SIL--EAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLR 237
            :.:  ....|:||.|.|..:|||..:..|..|.||..||:|:.|.|..|||    |...||.:::
Zfish   161 NFVCFTKHEPIGVCGAIIPWNFPLLMLMWKIAPALACGNTVVLKPAEQTPL----TALHVAALIK 221

  Fly   238 RNNLPP-VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDV-GVEVQRRFGKVILELGGNNA 299
            ....|| ||.:..| |...|..:.....::.::||||.:.|:.| .........:|.|||||.|.
Zfish   222 EAGFPPGVVNVVPGFGPTAGAAIAGHMNIDKLAFTGSTEVGQLVKAAAASSNLKRVTLELGGKNP 286

  Fly   300 LIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEA 364
            .|:...:::::|::....|.....||.||...|:.|.|.::::||:..|.:.|.::  ||..:|.
Zfish   287 CIVFADSDLQLAVEETQKGAFFNQGQACTAASRVYVQEPVYEEFVRLSVERAKNIV--IGDPMEP 349

  Fly   365 QTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFA 429
            :|..||...|...|...|.:...|..|..:.|||..::..|.::.||:.:.:.....:...|.|.
Zfish   350 RTSHGPQIDQHQFEKILALVDSGKKEGAKLEFGGCAVEDRGLFIHPTIFSDVKDHMRIAKEEIFG 414

  Fly   430 PIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGA 494
            |:..|:|.:.....|:..|..:.||::|:||.::.:|.....|  .:.|.|.:| ..|.......
Zfish   415 PVQCIMKFECQQDVIDRANSSQFGLTAAVFTRDVQRAMSVSAA--LEAGTVWVN-CYNALHAQTP 476

  Fly   495 FGGEKATGGGRESGSDAWKQYCKRATITVNHSGEL 529
            |||.|.:|.|||.|..|..:|.:...||:..|.:|
Zfish   477 FGGYKMSGNGRELGEYALAEYTEVKAITIKLSEQL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	133/485 (27%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	133/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810