DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh3a2

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_006246591.1	Gene:	Aldh3a2 / 65183	RGDID:	61866	Length:	584	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	131/528 - (24%)
Similarity:	228/528 - (43%)	Gaps:	96/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LIDQPEYSFLKELGLERDNPG-----VYSGQWQGRGPSV------------------------TS 66
            |:.:|. .:::.|.|..:..|     |:||...|..|:|                        ::
  Rat     8 LVQRPS-QWVRTLSLAAERWGLVHTRVWSGPVGGWKPAVPRSSELWRHPEQCLTGIVLLHLPRSA 71

  Fly    67 YDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVS 131
            :..|.    |..||  ||.|..|       ::..|..|...|.:.:..:...:::.::.:...::
  Rat    72 FSSGP----AMERQ--VQRLRQT-------FRSGRSRPLRFRLQQLEALRRMVQEREKDILAAIA 123

  Fly   132 LEVGK----IYSEGQGEVQEFIDICDYAVGLSRIYSGQLINSERADHSIL----EAW---RPLGV 185
            .::.|    .||.   ||...:...|:.:|    ...:|.::..|..::|    ||:   .||||
  Rat   124 ADLSKSELNAYSH---EVITILGEIDFMLG----NLPELASARPAKKNLLTMMDEAYVQPEPLGV 181

  Fly   186 VGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPPVVTLCQG 250
            |.:|.|:|:|..:.......|:..||:.:.|  ||.  :|..|.||:||:|.:.....:..:..|
  Rat   182 VLIIGAWNYPFVLTLQPLVGAIAAGNAAIVK--PSE--LSENTAKILAELLPQYLDQDLYMIVNG 242

  Fly   251 GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAA 315
            |.:....|:. :|.:.:.:||:...|:.|.....:....|.|||||.:...||...::.:|....
  Rat   243 GVEETTELLR-QRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRI 306

  Fly   316 LFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQ-QNVEN 379
            .:|.....||.|.....|:....|.||.|:::....|..   .|..::|    .|.:.: .|:.:
  Rat   307 TWGKYMNCGQTCIAPDYILCEASLQDQIVQKIKDTVKDF---YGENVKA----SPDYERIINLRH 364

  Fly   380 YKAAIAEAKSL--GGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQ 442
            :|    ..|||  |..:||||...:... |:.||::|.:..::.|:..|.|.||:.|:..|||::
  Rat   365 FK----RIKSLLEGQKIAFGGETDEATR-YIAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVEE 424

  Fly   443 AIEWNNEVEQGLSSAIFTENIGQAFKWI-------GAKGSDCGIVNINTTTNGAEIGGAFGGEKA 500
            ||.:.|:.|:.|:..||:.| .:..|.:       |..|:|   |.::.|.|..    .|||..|
  Rat   425 AINFINDREKPLALYIFSHN-NKLIKRVIDETSSGGVTGND---VIMHFTVNSL----PFGGVGA 481

  Fly   501 TGGGRESG 508
            :|.|...|
  Rat   482 SGMGAYHG 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	127/508 (25%)
Aldh3a2	XP_006246591.1	ALDH_F3AB	82..521	CDD:143450	116/447 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900