Protein Alignment Aldh7A1 and ALDH8A1

DIOPT Version :10

• Sequence 1: NP_649099.1
• Gene: Aldh7A1 / 40097
• FlyBaseID: FBgn0036857
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_072090.1
• Gene: ALDH8A1 / 64577
• HGNCID: 15471
• Length: 487
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 136/485 - (28%)
• Similarity: 230/485 - (47%)
• Gaps: 45/485 - (9%)

  Fly    64 VTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGK 128
            :.||||.||:...:|......|:|..:..|.||:..|.......|..::.|:.|.|.:..|...:
Human    25 IDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQ 89

  Fly   129 LVSLEVGKIYSEGQ-----GEVQEFIDICDYAVGLSRIYSGQLIN--SERAD-------HSILEA 179
            ..|.:.||..:..:     ..||.|           |.::...::  ||...       |..:.|
Human    90 AESKDQGKTLALARTMDIPRSVQNF-----------RFFASSSLHHTSECTQMDHLGCMHYTVRA 143

  Fly   180 WRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP- 243
              |:||.|:||.:|.|..:..|..|.|:..||:|:.|  || .|.|| |..::.::|.:..:||
Human   144 --PVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAK--PS-ELTSV-TAWMLCKLLDKAGVPPG 202

  Fly   244 VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESAN 307
            ||.:..| |..||:.||:...|.|:|||||..|...:.........|:.|||||.|..||.|.||
Human   203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDAN 267

  Fly   308 VKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVH 372
            :...:.|.:.......|:.|..|.||.|.:.::.:|:|..|...::.  |:|...:....:|.:.
Human   268 LDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKW--KVGIPSDPLVSIGALI 330

  Fly   373 TQQNVENYKAAIAEAKSLGGTVAFGGNVIQ-------RDGFYVEPTVITGLPHDASVVHRETFAP 430
            ::.::|..::.:..|.:.|..:..|..|.:       :.|:::.|||||.:..::..:..|.|.|
Human   331 SKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGP 395

  Fly   431 IVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAF 495
            :..::...:.::.||..|.|:.||::.:::.|:|:..:  .||....|:|..|.... .|:...|
Human   396 VTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPF 457

  Fly   496 GGEKATGGGRESGSDAWKQYCKRATITVNH 525
            ||.|::|.|||...|::..:.:..||||.|
Human   458 GGMKSSGIGREGAKDSYDFFTEIKTITVKH 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	136/485 (28%)
ALDH8A1	NP_072090.1	ALDH_F8_HMSADH	27..485	CDD:143412	133/479 (28%)