DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh7A1 and ALDH8A1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_072090.1	Gene:	ALDH8A1 / 64577	HGNCID:	15471	Length:	487	Species:	Homo sapiens

Alignment Length:	485	Identity:	136/485 - (28%)
Similarity:	230/485 - (47%)	Gaps:	45/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 VTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGK 128
            :.||||.||:...:|......|:|..:..|.||:..|.......|..::.|:.|.|.:..|...:
Human    25 IDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQ 89

  Fly   129 LVSLEVGKIYSEGQ-----GEVQEFIDICDYAVGLSRIYSGQLIN--SERAD-------HSILEA 179
            ..|.:.||..:..:     ..||.|           |.::...::  ||...       |..:.|
Human    90 AESKDQGKTLALARTMDIPRSVQNF-----------RFFASSSLHHTSECTQMDHLGCMHYTVRA 143

  Fly   180 WRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP- 243
              |:||.|:||.:|.|..:..|..|.|:..||:|:.|  || .|.|| |..::.::|.:..:||
Human   144 --PVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAK--PS-ELTSV-TAWMLCKLLDKAGVPPG 202

  Fly   244 VVTLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESAN 307
            ||.:..| |..||:.||:...|.|:|||||..|...:.........|:.|||||.|..||.|.||
Human   203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDAN 267

  Fly   308 VKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVH 372
            :...:.|.:.......|:.|..|.||.|.:.::.:|:|..|...::.  |:|...:....:|.:.
Human   268 LDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKW--KVGIPSDPLVSIGALI 330

  Fly   373 TQQNVENYKAAIAEAKSLGGTVAFGGNVIQ-------RDGFYVEPTVITGLPHDASVVHRETFAP 430
            ::.::|..::.:..|.:.|..:..|..|.:       :.|:::.|||||.:..::..:..|.|.|
Human   331 SKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGP 395

  Fly   431 IVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAF 495
            :..::...:.::.||..|.|:.||::.:::.|:|:..:  .||....|:|..|.... .|:...|
Human   396 VTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPF 457

  Fly   496 GGEKATGGGRESGSDAWKQYCKRATITVNH 525
            ||.|::|.|||...|::..:.:..||||.|
Human   458 GGMKSSGIGREGAKDSYDFFTEIKTITVKH 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	136/485 (28%)
ALDH8A1	NP_072090.1	ALDH_F8_HMSADH	27..485	CDD:143412	133/479 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810