DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_071992.2	Gene:	Aldh1l1 / 64392	RGDID:	621294	Length:	902	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	141/479 - (29%)
Similarity:	237/479 - (49%)	Gaps:	40/479 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQ--WRQVPAPVRGEIVRQIGDELRKYKEPLGKLV 130
            :|..|..|.:|....|.:::..:..|.||::.  |.::.|..||.::.::.|.:.:::|.|..:.
  Rat   443 NPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIE 507

  Fly   131 SLEVGKIYSEG-QGEVQEFIDICDYAVG-LSRIYSGQL-INSERADHSI-LEAWRPLGVVGVISA 191
            :|:.|.:|:.. :..|...|....|..| ..:|....: ||..|.:.:: |....|:||.|::..
  Rat   508 ALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIP 572

  Fly   192 YNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDV 254
            :|:|..:..|..|..|..||:|:.|.|..|||.::.    .||:..:..:|. ||.:..| |:.|
  Rat   573 WNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALK----FAELTLKAGIPKGVVNILPGSGSLV 633

  Fly   255 GQTLVADKRVNLVSFTGSCQTGRDV-------GVEVQRRFGKVILELGGNNALIIDESANVKMAL 312
            ||.|.....|..:.||||.:.|:.:       .|:      ||.|||||.:.|||....::..|:
  Rat   634 GQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVK------KVSLELGGKSPLIIFADCDLNKAV 692

  Fly   313 DAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGP----VHT 373
            ...:.......|:.|....|:.|.|.:|:|||:::|.:.:::  |||:.||..|..||    .|.
  Rat   693 QMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKM--KIGNPLERDTNHGPQNHEAHL 755

  Fly   374 QQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAK 438
            ::.||..:..:.|    |.|:..|||.:.|.||:.:|||.|.:.....:...|:|.||:.|.:..
  Rat   756 RKLVEYCQRGVKE----GATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFA 816

  Fly   439 --NVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKAT 501
              :||..:...|..|.||:|.:||.:|.:|. ::..| ...|.|.|| |.|..::...|||.|.:
  Rat   817 DGDVDAVLSRANATEFGLASGVFTRDINKAL-YVSDK-LQAGTVFIN-TYNKTDVAAPFGGFKQS 878

  Fly   502 GGGRESGSDAWKQYCKRATITVNH 525
            |.|::.|..|..:|.:..|:|..:
  Rat   879 GFGKDLGEAALNEYLRIKTVTFEY 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	141/479 (29%)
Aldh1l1	NP_071992.2	GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		Aldehyde dehydrogenase	417..902		141/477 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810