DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh9a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_071609.2	Gene:	Aldh9a1 / 64040	RGDID:	68409	Length:	497	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	143/506 - (28%)
Similarity:	240/506 - (47%)	Gaps:	30/506 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTI 90
            |:.::::.||    |...|..|..|...||       :..:::|.||:.||..:....:|:...:
  Rat     2 STGTFVVSQP----LNYRGGARVEPVDASG-------TEKAFEPATGREIATFKCSGEKEVNLAV 55

  Fly    91 GLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQGEVQEFIDICDYA 155
            ..|..|:|.|.:.....|.:::.:....:::.::.:..:.::..||...|.:.:|.......:|.
  Rat    56 ENAKAAFKIWSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSIFEARLDVDTSWQCLEYY 120

  Fly   156 VGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPS 220
            .||:...:|:.|............ .||||...|.|:|:|..:..|.:|.||..||::::|.:|.
  Rat   121 AGLAASMAGEHIQLPGGSFGYTRR-EPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPF 184

  Fly   221 TPLVSVATTKIVAEVLRRNNLPPVVTLCQGGTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQR 285
            ||:.::...:|..:....|.|..||   |||...||.|...:.|..||||||..||..:.....:
  Rat   185 TPVSALLLAEIYTKAGAPNGLFNVV---QGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAAK 246

  Fly   286 RFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGK 350
            ....:.|||||.:.|||....|:|.|:..||.....|.||.|....|:.|.:::.|.|.||:|.:
  Rat   247 GIKPITLELGGKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQ 311

  Fly   351 YKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQ------RDGFYVE 409
            .:::  |||..|...|.:||:....::|.....:..||..|.||..||....      :.|:|:.
  Rat   312 TQRI--KIGDPLLEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMT 374

  Fly   410 PTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGA-- 472
            |.::|....|.:.|..|.|.|::.||..:...:.:|..|:...||::.:||.:|.:|.: :.|
  Rat   375 PCILTNCTDDMTCVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHR-VAAEL 438

  Fly   473 KGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQYCKRATITV 523
            :...|.|.|.|.:.  .|:  .|||.|.:|.|||:|....:.|.:..|:.|
  Rat   439 QAGTCYINNYNVSP--VEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	136/481 (28%)
Aldh9a1	NP_071609.2	ALDH_F9_TMBADH	31..488	CDD:143409	134/466 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810