DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and aldh5a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_009290813.1	Gene:	aldh5a1 / 565235	ZFINID:	ZDB-GENE-070228-2	Length:	522	Species:	Danio rerio

Alignment Length:	498	Identity:	148/498 - (29%)
Similarity:	238/498 - (47%)	Gaps:	30/498 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QPEYSFLKELGLERDNPGVYSGQWQGRGPSVTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYK 98
            |..||......|.| ..|...|:|.....|...:||.||:.||||.....:|.:..:..|.:|:.
Zfish    35 QRPYSLDVSASLLR-TEGFIDGRWVSAASSFPVFDPATGEEIAKVSDCGTKEAQDAVNAAHKAFN 98

  Fly    99 QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIYSEGQGEVQEFIDICDYAVGLSRIYS 163
            .|:...|..|..::|:..|.:.:::|.|.||::.|.||...|..||:.......::....:|...
Zfish    99 LWKNHTAKERSILLRKWFDLIIQHREDLAKLITAECGKPMKESLGEMTYSASFLEWFSEEARRVY 163

  Fly   164 GQLINSERADHSILEAWRPLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVAT 228
            |.::.:...|..||...:|:||..:|:.:|||:|:.......||..|.:|:.|.|..|||.::|
Zfish   164 GDIVAAPAKDRKILILKQPVGVASIITPWNFPSAMITRKVGAALAVGCTVVVKPAEDTPLSALA- 227

  Fly   229 TKIVAEVLRRNNLPP----VVTLCQGGTD-VGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFG 288
               :||:..:..:|.    ||...:..|. ||:.|..|..|..:|||||..||:.:.........
Zfish   228 ---LAELSVQAGIPAGVFNVVPCSREKTPAVGELLCTDPLVAKISFTGSTATGKVLLRHAAGTVK 289

  Fly   289 KVILELGGNNALIIDESANVKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQ 353
            :|.:||||:...|:.:||:|..|:..|:......|||.|..:.|.:|...:||.||::| .|...
Zfish   290 RVSMELGGHAPFIVFDSADVDKAVAGAMGSKFRNSGQTCVCSNRFLVQTGIHDAFVEKL-AKTMD 353

  Fly   354 LISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPH 418
            ...|:||..|..|..||:...:..|..:..:|:|...|..|..||..:|  |.::|||:::.:..
Zfish   354 AELKLGHGSEPSTTQGPLINSRAAEKVEKQVADAVDHGAVVVRGGKRLQ--GSFMEPTLLSNVTS 416

  Fly   419 DASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNIN 483
            |...:..|||.|::.::|.....:|:...|....||:...::.::.|.  |..|:..:.|:|.:|
Zfish   417 DMLCMREETFGPLIPVVKFNTEQEALAIANASPVGLAGYFYSRDMAQI--WRVAEQMEVGMVGVN 479

  Fly   484 ----TTTNGAEIGGAFGGEKATGGGRES---GSDAW---KQYC 516
                :||.     ..|||.|.:|.|||.   |.|.:   |..|
Zfish   480 EGMISTTE-----APFGGIKQSGLGREGSIYGVDEYLEIKYMC 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	143/481 (30%)
aldh5a1	XP_009290813.1	ALDH_F5_SSADH_GabD	66..518	CDD:143421	139/466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910