DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and ALDH7A1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001173.2	Gene:	ALDH7A1 / 501	HGNCID:	877	Length:	539	Species:	Homo sapiens

Alignment Length:	537	Identity:	298/537 - (55%)
Similarity:	393/537 - (73%)	Gaps:	14/537 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LPRRLVTQTASYSS-----------SSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVTS 66
            |||.|....|..|.           .|:.||:||:|::||||||..:|.|||:|.|.|||..:|:
Human     4 LPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITT 68

  Fly    67 YDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVS 131
            |.|...:|||:|||.:|.:.|.|:..|.||:|.|..:|||.||||||||||.||:..:.||.|||
Human    69 YCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVS 133

  Fly   132 LEVGKIYSEGQGEVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPN 196
            ||:|||..||.|||||::|||||||||||:..|.::.|||:.|:::|.|.|:|:||:|:|:|||.
Human   134 LEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPV 198

  Fly   197 AVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLP-PVVTLCQGGTDVGQTLVA 260
            ||:|||.|||:..||..||||||:|.|:|||.|||:|:||..|.|| .:.:|..||.|:|..:..
Human   199 AVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAK 263

  Fly   261 DKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQ 325
            |:||||:|||||.|.|:.||:.||.|||:.:||||||||:|..|.|::.:.:.:|||..:||:||
Human   264 DERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ 328

  Fly   326 RCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSL 390
            ||||.||:.:||.:||:.|..|...|.|:  ::|:..:...|.||:||:|.|..:..|:.|||..
Human   329 RCTTARRLFIHESIHDEVVNRLKKAYAQI--RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKE 391

  Fly   391 GGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGLS 455
            ||||.:||.|:.|.|.|||||::|||.||||:.|.||||||:|:.|.||.::...|||||:||||
Human   392 GGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLS 456

  Fly   456 SAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQYCKRAT 520
            |:|||:::|:.|:|:|.|||||||||:|..|:||||||||||||.|||||||||||||||.:|:|
Human   457 SSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRST 521

  Fly   521 ITVNHSGELACAQGVVF 537
            .|:|:|.:|..|||:.|
Human   522 CTINYSKDLPLAQGIKF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	273/475 (57%)
ALDH7A1	NP_001173.2	ALDH_F7_AASADH	53..527	CDD:143448	273/475 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160001
Domainoid	1	1.000	555	1.000	Domainoid score	I244
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H913
Inparanoid	1	1.050	620	1.000	Inparanoid score	I886
Isobase	1	0.950	-	0	Normalized mean entropy	S1056
OMA	1	1.010	-	-		QHG63481
OrthoDB	1	1.010	-	-		D223310at33208
OrthoFinder	1	1.000	-	-		FOG0006553
OrthoInspector	1	1.000	-	-		oto90047
orthoMCL	1	0.900	-	-		OOG6_103382
Panther	1	1.100	-	-	O	PTHR43521
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2392
SonicParanoid	1	1.000	-	-		X4203
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750