DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and aldh8a1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001004540.1	Gene:	aldh8a1 / 447801	ZFINID:	ZDB-GENE-040912-3	Length:	487	Species:	Danio rerio

Alignment Length:	488	Identity:	125/488 - (25%)
Similarity:	222/488 - (45%)	Gaps:	51/488 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 VTSYDPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGD--ELRKYKEPL 126
            :.|:||.||:...||.....:|:...:..|.||:..|.......|.:::.::.|  |.|     |
Zfish    25 IDSFDPSTGEVYCKVPDSGAEEVNAAVRAAKEAFPDWSAKSPADRSKVLNKLADLIEAR-----L 84

  Fly   127 GKLVSLEVGKIYSEGQGEVQEF---IDICDYAVGLSRIYSGQLI----NSERADHSILEAWR--- 181
            .:.|..|     |:.||:...|   :||...|... |.::..::    :..:.||.....:.
Zfish    85 EEFVQAE-----SKDQGKTITFARNVDIPRSAYNF-RFFASSVLHHTNDCSQMDHMGCLNYTIRC 143

  Fly   182 PLGVVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VV 245
            |:||.|:||.:|.|..:..|..|.|:.|||:|:.|.:..|.:    |..::.::|.....|| ||
Zfish   144 PVGVAGLISPWNLPLYLLTWKIAPAVATGNTVVAKPSEMTSV----TAWMMCQLLEEAGFPPGVV 204

  Fly   246 TLCQG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVK 309
            .:..| |...|..||:...|.|:|||||..|.|.:.........|:.|||||.|..||...|:::
Zfish   205 NIVFGTGPRAGDALVSHPDVPLISFTGSTATARLITERSAPHCKKLSLELGGKNPAIIFADADME 269

  Fly   310 MALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQ 374
            ..:...:.......|:.|..|.||.|...::.:|:...|...::.  |.|...:.....|.:.::
Zfish   270 QCISTTVRSSFSNQGEICLCTSRIFVERSVYPEFLTRFVEATRRW--KTGVPSDPSNDNGALISK 332

  Fly   375 QNVENYKAAIAEAKSLGGTVAFGGNVIQR-------DGFYVEPTVITGLPHDASVVHRETFAPIV 432
            ::::..|..|..|.:.|..|..|..|.:.       .|:::.||:|:|:...::::..|.|.|:.
Zfish   333 EHLQKVKGYITLALAEGAQVHCGEGVDKLALPQQNIGGYFMLPTIISGVKDSSALMQEEIFGPVT 397

  Fly   433 YILKAKNVDQAIEWNNEVEQGLSSAIFTENIGQAFK-----WIGAKGSDCGIVNINTTTNGAEIG 492
            .:......::.|...|.|..|||:.:::.::|:..:     ..|...::|.:|.        ::.
Zfish   398 CVTPFDEEEEVISRANNVRYGLSATVWSRDVGRVHRVARKLQAGLVWTNCWLVR--------DLN 454

  Fly   493 GAFGGEKATGGGRESGSDAWKQYCKRATITVNH 525
            ..|||.|.:|.|||.|.|::..:.:..::||.|
Zfish   455 LPFGGMKHSGIGREGGKDSYHFFTEVKSVTVKH 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	125/488 (26%)
aldh8a1	NP_001004540.1	ALDH_F8_HMSADH	27..485	CDD:143412	122/482 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810