DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and aldh9a1b

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_009295330.1	Gene:	aldh9a1b / 399481	ZFINID:	ZDB-GENE-040120-5	Length:	539	Species:	Danio rerio

Alignment Length:	529	Identity:	144/529 - (27%)
Similarity:	249/529 - (47%)	Gaps:	50/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QPEYSFLKELGLERD--NPGVY------------SGQWQGRGP-----------------SVTSY 67
            :.|:||..::.|.|.  .||.|            ||..|.:.|                 |...:
Zfish    13 EEEFSFRLKMALMRCLLPPGFYRTLYHPWTRCASSGTLQIKDPLNFWCGARVDLKDVKTKSEPVF 77

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEAYKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSL 132
            :|.||:.:.:::.....|::..:..|..|:|.||::....|..::.:....:.|.:|.:.::..:
Zfish    78 EPATGRVLCRLQTCGSAEVDAAVRNASAAFKVWRKLSGMERARVMLEAARLIEKRREEIAEMEVI 142

  Fly   133 EVGKIYSEGQGEVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNA 197
            ..||..:|.:.:|.......:|..|.:...|||.:.......:.... .|.||...|.|:|:|..
Zfish   143 NNGKSITEARLDVDSARLSIEYFAGQATTLSGQHVQLPGGSFAYTRR-EPFGVCVGIGAWNYPFQ 206

  Fly   198 VFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQGGTDVGQTLVAD 261
            :..|.:|.|:..|||:::|.:|.||:.:|    ::||:.|:...|. :..:.|||.:.|..|...
Zfish   207 IAAWKSAPAIACGNSMVFKPSPLTPVTAV----LLAEIYRQAGAPEGLFNVVQGGQETGSLLCLH 267

  Fly   262 KRVNLVSFTGSCQTGRDVGVEVQRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSGQR 326
            ..|..||||||..||:.:.....|....|.|||||.:.|||.|..:::.|:..||.....:.||.
Zfish   268 PSVEKVSFTGSVPTGKKIMEMASRGVKAVTLELGGKSPLIIFEDTDLENAVRGALMANFLSQGQV 332

  Fly   327 CTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKSLG 391
            |:...|:.|...:..||:||:|.:.|.:  .||..|..:|.:|.:.::.:::.....:.:||:.|
Zfish   333 CSNGTRVFVQSSIVPQFLKEVVRRTKAI--SIGDPLLDETRMGALVSKAHLDKVLRYVEQAKNEG 395

  Fly   392 GTVAFGGNVIQ------RDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEV 450
            ..|..||....      :||:|:.|.|:.....|.:.|..|.|.|::.:|.....|:.:...|:.
Zfish   396 AQVLCGGEPFSPADPKLKDGYYMTPCVLDSCTDDMTCVKEEIFGPVMSVLTFDTEDEVLRRANDS 460

  Fly   451 EQGLSSAIFTENIGQAFKWI-GAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDAWKQ 514
            :.||::.:||:::.:|.:.| ..:...|.|.|.|.|.  .|:  .|||.||:|.|||:|....:.
Zfish   461 DLGLAAGVFTKDVKRAHRVIENLQAGSCFINNYNITP--VEV--PFGGFKASGIGRENGQVTIEF 521

  Fly   515 YCKRATITV 523
            |.:..|:.|
Zfish   522 YSQLKTVVV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	138/510 (27%)
aldh9a1b	XP_009295330.1	ALDH_F9_TMBADH	76..533	CDD:143409	131/466 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810