DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and aldh2.1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_956784.1	Gene:	aldh2.1 / 393462	ZFINID:	ZDB-GENE-040426-1262	Length:	516	Species:	Danio rerio

Alignment Length:	541	Identity:	147/541 - (27%)
Similarity:	247/541 - (45%)	Gaps:	55/541 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRNISKLALPRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVT--SY 67
            ||.:.....|:.....:..:|:..:..: ||:..:         |....:.:|.......|  :.
Zfish     2 LRTVFSRTFPQVFRISSCQHSTIPAPNV-QPDVHY---------NKIFINNEWHDAVSKKTFPTI 56

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVRQIGDELRKYKEPLGKL 129
            :|.|.:.|..|.:|:..:::..:..|.:|:|   .||::.|..||.::.::.|.:.:....|.:|
Zfish    57 NPATAEVICHVAEGDKADVDKAVKAARDAFKLGSPWRRMDASQRGLLLNRLADCIERDAAYLAEL 121

  Fly   130 VSLEVGKIYSEGQGEVQEFIDIC----------DYAVGLSRIYSGQLINSERADHSILEAWRPLG 184
            .:|:.||.|:         :..|          .|..|.:..:.|:.|..: .::.......|:|
Zfish   122 ETLDNGKPYT---------LSFCVDLPMVVKCLRYYAGWADKWEGKTIPID-GNYFCYTRHEPIG 176

  Fly   185 VVGVISAYNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLC 248
            |.|.|..:|||..:.......||.|||:|:.|.|..|||.::....::.||    ..|. ||.:.
Zfish   177 VCGQIIPWNFPLLMQALKLGPALATGNTVVMKVAEQTPLTALYIASLIKEV----GFPAGVVNIV 237

  Fly   249 QG-GTDVGQTLVADKRVNLVSFTGSCQTGRDVGVEVQR-----RFGKVILELGGNNALIIDESAN 307
            .| |...|..:.:...|:.|:||||    .|||..:|:     ....|.|||||.:..||...||
Zfish   238 PGFGPTAGAAIASHMDVDKVAFTGS----TDVGHLIQQASSASNLKNVSLELGGKSPNIILSDAN 298

  Fly   308 VKMALDAALFGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVH 372
            ::.|::.|........||.|....|..|.|.::|:||:..|.:.|..|  :|...:..|..||..
Zfish   299 MEEAVEQAHSALFFNQGQCCCAGTRTFVQESIYDEFVERSVERAKNRI--VGDPFDLNTEQGPQV 361

  Fly   373 TQQNVENYKAAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKA 437
            .:...:.....|:..|..|..:..||......|::::|||...:..|.::...|.|.|::.|||.
Zfish   362 DEDQFKKVLGYISSGKREGAKLMCGGAPAAERGYFIQPTVFGDVKDDMTIAREEIFGPVMQILKF 426

  Fly   438 KNVDQAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATG 502
            |::::.||..|:.:.||::|:||:||.:| .:| :.|...|.|.|| ..|...:...|||.||:|
Zfish   427 KSLEEVIERANDSKYGLAAAVFTQNIDKA-NYI-SHGLRAGTVWIN-CYNVFGVQAPFGGYKASG 488

  Fly   503 GGRESGSDAWKQYCKRATITV 523
            .|||.|......|.:..|:|:
Zfish   489 IGRELGEYGLDIYTEVKTVTI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	140/495 (28%)
aldh2.1	NP_956784.1	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	143/512 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810