DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and CG8665

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_610107.1	Gene:	CG8665 / 35407	FlyBaseID:	FBgn0032945	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	131/474 - (27%)
Similarity:	227/474 - (47%)	Gaps:	30/474 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEA-YKQWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVS 131
            :|...:.:.||...:..:::..:..|..| |..|||:....||:::..:.|.:.:.||.|..:.|
  Fly   454 NPTNEEVLCKVACASATDVDKAVRAAHSAFYGSWRQITPRQRGQLMLNLADLMERNKEELATIES 518

  Fly   132 LEVGKIYSEG-QGEVQEFIDICDYAVGLSRIYSGQLI--NSERADHSILEAWR--PLGVVGVISA 191
            ::.|.:|:.. :..|...|:...|..|......|..|  |..| .:::|...|  |:||.|:|:.
  Fly   519 VDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPAR-PNNVLTFTRKEPIGVCGLITP 582

  Fly   192 YNFPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDV 254
            :|:|..:..|..|..:..||:.|.|.|.:.||.::.    .||:..|...|| |:.:..| |:|.
  Fly   583 WNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALK----FAELTVRAGFPPGVINVLPGKGSDA 643

  Fly   255 GQTLVADKRVNLVSFTGSCQTGRDVGVE-VQRRFGKVILELGGNNALIIDESANVKMALDAALFG 318
            ||.:...:.|..:.||||...|:.:... ......|..|||||.:.|||....::..|:...:..
  Fly   644 GQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLIIFADCDMDKAVKHGMSS 708

  Fly   319 CIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGP----VHTQQNVEN 379
            .....|:.|....|:.|.:::||:|::.::...:.:  .||..|:..|..||    .|..:.:|.
  Fly   709 VFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTM--TIGDPLDRSTAHGPQNHKAHFDKLLEF 771

  Fly   380 YKAAIAEAKSLGGTVAFGG-NVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILK--AKNVD 441
            .:..:.|    |..:.:|| .|....|::..|||.|.:..|..:...|:|.||:.|.|  ..::|
  Fly   772 CRRGVDE----GAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPIMIISKFNGSDID 832

  Fly   442 QAIEWNNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRE 506
            ..::..|..|.||:|.:||::||:|..:  |...:.|.|.:| ..|..::...|||.|.:|.|::
  Fly   833 SLMQRANRTEYGLASGVFTKDIGKALNF--ADRIEAGTVFVN-VYNKTDVAAPFGGFKQSGYGKD 894

  Fly   507 SGSDAWKQYCKRATITVNH 525
            .|.:|..:|.|...:||.:
  Fly   895 LGQEALNEYLKTKCVTVEY 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	131/474 (28%)
CG8665	NP_610107.1	Fmt	4..315	CDD:223301
		FMT_core	5..207	CDD:294280
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	338..403	CDD:278949
		PLN02466	396..909	CDD:215259	129/468 (28%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	131/472 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740