DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh1b1

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001011975.1	Gene:	Aldh1b1 / 298079	RGDID:	1306737	Length:	519	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	153/535 - (28%)
Similarity:	254/535 - (47%)	Gaps:	40/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SKLALPRRLVTQ--TASYSSSSSY--LIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVT--SY 67
            ::..:||.|..|  |.|||::::.  .|..||.         |.|....:.:|.......|  :.
  Rat     4 ARFLVPRLLCLQGRTTSYSTAAALPNPIPNPEI---------RYNQLFINNEWHDAVSKKTFPTV 59

  Fly    68 DPGTGQPIAKVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVRQIGDELRKYKEPLGKL 129
            :|.||:.|..|.:|:..:::..:..|.||::   .||::.|..||.::.::.|.:.:.:..|..|
  Rat    60 NPTTGEVIGHVAEGDRADVDLAVRAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASL 124

  Fly   130 VSLEVGKIYSEGQG-EVQEFIDICDYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYN 193
            .:|:.||.:.|... ::.|.|.:..|..|.:..:.|:.|..: .:|.......|:||.|.|..:|
  Rat   125 ETLDNGKPFQESYVLDLDEVIKVYRYLAGWADKWHGKTIPMD-GEHFCFTRHEPVGVCGQIIPWN 188

  Fly   194 FPNAVFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVGQ 256
            ||..:.||..|.||.|||:|:.|.|..|||.::    .:|.:::....|| ||.:..| |...|.
  Rat   189 FPLVMQGWKLAPALATGNTVVMKVAEQTPLSAL----YLASLIKEAGFPPGVVNIITGYGPTAGA 249

  Fly   257 TLVADKRVNLVSFTGSCQTGRDVGVEVQRRFG-----KVILELGGNNALIIDESANVKMALDAAL 316
            .:.....|:.|:||||    .:||..:|:..|     :|.|||||.:..|:...|::..|:|...
  Rat   250 AIAQHMDVDKVAFTGS----TEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMDHAVDQCH 310

  Fly   317 FGCIGTSGQRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYK 381
            .......||.|....|..|.|.::.:|::..|.|.|:  .|:|:..|..|..||...::..|...
  Rat   311 EALFFNMGQCCCAGSRTFVEESIYHEFLERTVEKAKK--RKVGNPFELDTQQGPQVDKEQFEKIL 373

  Fly   382 AAIAEAKSLGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEW 446
            ..|...:..|..:..||......||:::|||...:..|..:...|.|.|:..:.|.|.:::.|:.
  Rat   374 GYIRLGQKEGAKLLCGGERFGERGFFIKPTVFGNVQDDMRIAREEIFGPVQPLFKFKKIEEVIQR 438

  Fly   447 NNEVEQGLSSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGAFGGEKATGGGRESGSDA 511
            .|....||::|:||.::.:|..:  ::....|.|.:| |.|.......|||.|.:|.|||.|.|.
  Rat   439 ANNTRYGLAAAVFTRDLDKALYF--SQALQAGTVWVN-TYNIVTCHTPFGGFKESGNGRELGEDG 500

  Fly   512 WKQYCKRATITVNHS 526
            .|.|.:..|:|:..|
  Rat   501 LKAYTEVKTVTIKVS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	139/487 (29%)
Aldh1b1	NP_001011975.1	PLN02466	13..510	CDD:215259	147/519 (28%)
Aldh1b1	NP_001011975.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	143/502 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810