DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh7A1 and Aldh2

DIOPT Version :9

Sequence 1:	NP_649099.1	Gene:	Aldh7A1 / 40097	FlyBaseID:	FBgn0036857	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	145/527 - (27%)
Similarity:	250/527 - (47%)	Gaps:	44/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PRRLVTQTASYSSSSSYLIDQPEYSFLKELGLERDNPGVYSGQWQGRGPSVT--SYDPGTGQPIA 76
            ||.....:|:.:|:......|||. |..::.:        :.:|.......|  :.:|.||:.|.
  Rat    13 PRLSRLLSAAATSAVPAPNQQPEV-FCNQIFI--------NNEWHDAVSKKTFPTVNPSTGEVIC 68

  Fly    77 KVRQGNVQELEHTIGLAVEAYK---QWRQVPAPVRGEIVRQIGDELRKYKEPLGKLVSLEVGKIY 138
            :|.:||.::::..:..|..|::   .||::.|..||.::.::.|.:.:.:..|..|.:|:.||.|
  Rat    69 QVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPY 133

  Fly   139 SEGQGEVQEFIDI-----C-DYAVGLSRIYSGQLINSERADHSILEAWRPLGVVGVISAYNFPNA 197
                 .:...:|:     | .|..|.:..|.|:.|..: .|........|:||.|.|..:|||..
  Rat   134 -----VISYLVDLDMVLKCLRYYAGWADKYHGKTIPID-GDFFSYTRHEPVGVCGQIIPWNFPLL 192

  Fly   198 VFGWNAAIALTTGNSVLWKGAPSTPLVSVATTKIVAEVLRRNNLPP-VVTLCQG-GTDVGQTLVA 260
            :..|....||.|||.|:.|.|..|||    |...||.:::....|| ||.:..| |...|..:.:
  Rat   193 MQAWKLGPALATGNVVVMKVAEQTPL----TALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 253

  Fly   261 DKRVNLVSFTGSCQTGRDVGVEV-QRRFGKVILELGGNNALIIDESANVKMALDAALFGCIGTSG 324
            .:.|:.|:||||.:.|..:.|.. .....:|.|||||.:..||...|::..|::.|.|......|
  Rat   254 HEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQG 318

  Fly   325 QRCTTTRRIIVHEKLHDQFVKELVGKYKQLISKIGHQLEAQTLVGPVHTQQNVENYKAAIAEAKS 389
            |.|....|..|.|.::|:||:..|.:.|..:  :|:..:::|..||...:...:.....|...:.
  Rat   319 QCCCAGSRTFVQEDVYDEFVERSVARAKSRV--VGNPFDSRTEQGPQVDETQFKKILGYIKSGQQ 381

  Fly   390 LGGTVAFGGNVIQRDGFYVEPTVITGLPHDASVVHRETFAPIVYILKAKNVDQAIEWNNEVEQGL 454
            .|..:..||......|::::|||...:....::...|.|.|::.|||.|.:::.:...|..:.||
  Rat   382 EGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGL 446

  Fly   455 SSAIFTENIGQAFKWIGAKGSDCGIVNINTTTNGAEIGGA---FGGEKATGGGRESGSDAWKQYC 516
            ::|:||:::.:| .:: ::....|.|.||.    .::.||   |||.|.:|.|||.|....:.|.
  Rat   447 AAAVFTKDLDKA-NYL-SQALQAGTVWINC----YDVFGAQSPFGGYKMSGSGRELGEYGLQAYT 505

  Fly   517 KRATITV 523
            :..|:||
  Rat   506 EVKTVTV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh7A1	NP_649099.1	ALDH_F7_AASADH	51..526	CDD:143448	137/490 (28%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	141/507 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810